Buccoval lotion

Buccoval

  • Active Ingredient: Metronidazole
  • 500 mg, 400 mg, 250 mg, 200 mg
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What is Buccoval?

The active ingredient of Buccoval brand is metronidazole. Metronidazole is an antibiotic that fights bacteria.

Used for

Buccoval is used to treat diseases such as: Amebiasis, Aspiration Pneumonia, Bacteremia, Bacterial Infection, Bacterial Vaginitis, Balantidium coli, Bone infection, Clostridial Infection, Crohn's Disease, Acute, Crohn's Disease, Maintenance, Deep Neck Infection, Dental Abscess, Dientamoeba fragilis, Diverticulitis, Dracunculiasis, Endocarditis, Giardiasis, Helicobacter Pylori Infection, Intraabdominal Infection, Joint Infection, Lemierre's Syndrome, Meningitis, Nongonococcal Urethritis, Pelvic Inflammatory Disease, Peritonitis, Pneumonia, Pouchitis, Pseudomembranous Colitis, Skin or Soft Tissue Infection, STD Prophylaxis, Surgical Prophylaxis, Trichomoniasis.

Side Effect

Possible side effects of Buccoval include: constipation; drowsiness; bloating; confusion; vomiting.

How to Buy Buccoval cream online?

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Can Buccoval cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the ones associated with Buccoval. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Carcinogenesis, Mutagenesis, Impairment Of Fertility

Tumors affecting the liver, lungs, mammary, and lymphatic tissues have been detected in several studies of Buccoval in rats and mice, but not hamsters.

Pulmonary tumors have been observed in all six reported studies in the mouse, including one study in which the animals were dosed on an intermittent schedule (administration during every fourth week only). Malignant liver tumors were increased in male mice treated at approximately 1500 mg/m² (similar to the maximum recommended daily dose, based on body surface area comparisons). Malignant lymphomas and pulmonary neoplasms were also increased with lifetime feeding of the drug to mice. Mammary and hepatic tumors were increased among female rats administered oral Buccoval compared to concurrent controls. Two lifetime tumorigenicity studies in hamsters have been performed and reported to be negative.

Buccoval has shown mutagenic activity in in vitro assay systems including the Ames test. Studies in mammals in vivo have failed to demonstrate a potential for genetic damage.

Buccoval failed to produce any adverse effects on fertility or testicular function in male rats at doses up at 400 mg/kg/day (similar to the maximum recommended clinical dose, based on body surface area comparisons) for 28 days. However, rats treated at the same dose for 6 weeks or longer were infertile and showed severe degeneration of the seminiferous epithelium in the testes as well as marked decreases in testicular spermatid counts and epididymal sperm counts. Fertility was restored in most rats after an eight week, drug-free recovery period.

Buccoval and Alcohol

Consuming alcohol while taking Buccoval can cause unwanted symptoms, such as:

  • Upset stomach
  • Stomach cramps
  • Vomiting
  • Fast heartbeat
  • Headache
  • Flushing
  • Sweating

Don't drink alcohol while using this medicine, and for at least three days after you stop taking it.

Be sure to check the labels of foods and other products to make sure they don't contain alcohol.

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Buccoval is commonly prescribed to treat an infection called bacterial vaginosis. It is also prescribed before gynaecological surgery and surgery on the intestines to prevent infection from developing. It can safely be taken by people who are allergic to penicillin.

Buccoval is also used, alongside other medicines, to get rid of Helicobacter pylori, a bacterial infection often associated with stomach ulcers.

Buccoval is available as a skin preparation also. This leaflet does not give information about Buccoval when it is used for skin conditions, but there is more information available in a separate leaflet called Buccoval skin gel and cream.

What if I forget to use it?

If you forget to use Buccoval cream or gel, put it on as soon as you remember, unless it's nearly time for your next dose. Do not use it more than twice a day unless your doctor tells you to. Then continue to use the cream or gel at the usual time.

What other drugs will affect Buccoval?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your current medicines and any you start or stop using, especially:

a blood thinner - warfarin, Coumadin, Jantoven.

phenytoin or phenobarbital

This list is not complete. Other drugs may interact with Buccoval, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Study Data

There are published data from case-control studies, cohort studies, and 2 meta-analyses that included more than 5000 pregnant women who used Buccoval systemically during pregnancy

Many studies included first trimester exposures

One study showed an increased risk of cleft lip, with or without cleft palate, in infants exposed to Buccoval in utero; however, these findings were not confirmed

In addition, more than 10 randomized, placebo-controlled clinical trials that together enrolled over 5000 pregnant women assessed the possible effect of systemic antibiotic treatment (including with Buccoval) for bacterial vaginosis on the incidence of preterm delivery; most studies did not show an increased risk of congenital anomalies or other adverse fetal outcomes following Buccoval exposure during pregnancy

Three studies conducted to assess the risk of infant cancer following systemic Buccoval exposure during pregnancy did not show an increased risk; however, the ability of these studies to detect such a signal was limited

Why is Buccoval prescribed to patients?

  • Flagyl is used to treat parasitic infections including Giardia infections of the small intestine, amebic liver abscess, and amebic dysentery (infection of the colon causing bloody diarrhea), bacterial vaginosis, trichomonas vaginal infections, and carriers of trichomonas (both sexual partners) who do not have symptoms of infection.
  • Flagyl is also used alone or in combination with other antibiotics in treating abscesses in the liver, pelvis, abdomen, and brain caused by susceptible anaerobic bacteria.
  • Flagyl is also used in treating infection of the colon caused by a bacterium called C. difficile. Many commonly-used antibiotics can alter the type of bacteria that inhabit the colon. C. difficile is an anaerobic bacterium that can infect the colon when the normal types of bacteria in the colon are inhibited by common antibiotics. This leads to inflammation of the colon (pseudomembranous colitis) with severe diarrhea and abdominal pain.)
  • Flagyl also is used in combination with other drugs to treat Helicobacter pylori (H. pylori) that causes stomach or intestinal ulcers.
  • Flagyl topical gel is used for treating acne rosacea.
  • Flagyl vaginal gel is used for treating bacterial vaginosis.

Buccoval Overdose

Symptoms of a Buccoval overdose may include:

  • Dizziness
  • Nausea
  • Vomiting
  • Loss of coordination or balance
  • Seizures
  • Numbness or tingling

If you suspect an overdose, contact a poison control center or emergency room immediately.

You can get in touch with a poison control center at 800-222-1222.

6. Vaginal gel

For treating bacterial vaginosis, you'll use an applicator to put the Buccoval gel into your vagina. The usual dose is 1 applicator full, every night for 5 nights. It's recommended that you do not use the gel while having your period.

How to use Buccoval

Take this medication by mouth as directed by your doctor. To prevent stomach upset, take this medication with food or a full glass of water or milk. The dosage is based on your medical condition and response to treatment.

For the best effect, take this antibiotic at evenly spaced times. To help you remember, take this medication at the same time(s) every day.

Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection.

Tell your doctor if your condition lasts or gets worse.

Busulfan

Buccoval has been reported to increase plasma concentrations of busulfan, which can result in an increased risk for serious busulfan toxicity. Buccoval should not be administered concomitantly with busulfan unless the benefit outweighs the risk. If no therapeutic alternatives to Buccoval are available, and concomitant administration with busulfan is medically needed, frequent monitoring of busulfan plasma concentration should be performed and the busulfan dose should be adjusted accordingly.

Contraindications

  • Hypersensitivity to Buccoval or other nitroimidazoles (although cautious desensitization has been applied)
  • Pregnancy, 1st trimester (controversial)
  • Use of disulfiram within past 2 weeks; use of alcohol during therapy or within 3 days of discontinuing therapy

Effects of Drug Abuse

  • No information available

  • See "What Are Side Effects Associated with Using Buccoval?"

  • Encephalopathcy, seizures, aseptic meningitis, and neuropathies reported with increase in dose and chronic therapy
  • Superinfection may occur with prolonged use
  • See "What Are Side Effects Associated with Using Buccoval?"

  • Encephalopathy, seizures, aseptic meningitis, and neuropathies reported with increase in dose and chronic therapy
  • Superinfection may occur with prolonged use
  • Severe hepatic impairment; administer lower doses with caution
  • Use with caution; potential accumulation in end stagerenal disease; supplemental doses may be needed in patients receiving hemodialysis
  • Use with caution in history of blood dyscrasias, heart failure, hepatic failure, H. pylori infection, renal impairment
  • Avoid alcohol while taking medication and for at least 1 day after discontinuation
  • Antiandrogen: May cause gynecomastia
  • Known or previously unrecognized candidiasis may present more prominent symptoms during therapy with Buccoval Injection and requires treatment with a candicidal agent

  • Buccoval may be acceptable for use during pregnancy. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. There are published data from case-control studies, cohort studies, and 2 meta-analyses that included more than 5000 pregnant women who used Buccoval systemically during pregnancy
  • Many studies included first trimester exposures. One study showed an increased risk of cleft lip, with or without cleft palate, in infants exposed to Buccoval in utero; however, these findings were not confirmed
  • In addition, more than 10 randomized, placebo-controlledclinical trials that together enrolled over 5000 pregnant women assessed the possible effect of systemic antibiotic treatment (including with Buccoval) for bacterial vaginosis on the incidence of preterm delivery; most studies did not show an increased risk of congenital anomalies or other adverse fetal outcomes following Buccoval exposure during pregnancy
  • Three studies conducted to assess the risk of infantcancer following systemic Buccoval exposure during pregnancy did not show an increased risk; however, the ability of these studies to detect such a signal was limited.
  • Buccoval is excreted in human milk; it is not recommended for use while breastfeeding
  • Following oral administration, concentrations in human milk are similar to concentrations in plasma
  • Potential for tumorigenicity shown in animal studies; a decision should be made whether to discontinue nursing or to discontinue Buccoval; breastfeeding women may choose to pump and discard milk for the duration of therapy and for 24 hours after therapy ends and to feed her infant stored human milk or formula

Why is this medication prescribed?

Buccoval capsules and tablets are used to treat infections of the reproductive system, gastrointestinal (GI) tract, skin, heart, bone, joint, lung, blood, nervous system, and other areas of the body. Buccoval capsules and tablets are also used to treat sexually transmitted diseases (STDs). Buccoval extended-release (long-acting) tablets are used to treat bacterial vaginosis (an infection caused by too much of certain types of harmful bacteria in the vagina) in women. Buccoval is in a class of medications called nitroimidazole antimicrobials. It works by stopping the growth of bacteria.

Antibiotics will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.


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