Before taking Bonzol, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
This medication may affect the sperm. Consult your doctor for more details.
This medication must not be used during pregnancy. It may harm the unborn baby. If you become pregnant or think you may be pregnant, tell your doctor right away. (See also Warning section.)
It is unknown if this medication passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.
Pregnancy and breastfeeding
Bonzol should not be used during pregnancy as it can cause masculinisation (development of male-like features) of a female foetus . If you suspect that you may be pregnant while taking Bonzol, you should stop taking the drug and contact your gynaecologist immediately.
It is not known if Bonzol is excreted in the breastmilk nor whether it has harmful effects on the infant. Therefore, you should not take Bonzol while breastfeeding .
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
An overdose of Bonzol is not expected to produce life threatening symptoms. However, long term use of high doses can lead to symptoms such as weight gain, increased acne or facial hair, menstrual problems, or breast changes.
Bonzol (Danocrine) is the 2,3,isoxazol derivative of 17α-ethyl testosterone and has been tested in patients with gynecomastia of varying causes with response rates of 77% to 100%.
What should I avoid while taking Bonzol?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Bonzol S >
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
In rare cases, Bonzol can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.
Call your doctor at once if you have a serious side effect such as:
- sudden numbness or weakness (especially on one side of the body), confusion, problems with speech or balance;
- severe headache, ringing in your ears, dizziness, nausea, vomiting, vision problems, pain behind your eyes;
- chest pain, sudden cough, wheezing, rapid breathing, coughing up blood;
- pain, swelling, warmth, or redness in one or both legs;
- swelling or rapid weight gain, especially in your face and midsection;
- bloody, black, or tarry stools;
- cough up blood or vomit that looks like coffee grounds; or
- upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious side effects may include:
- acne or other skin problems, increased sweating;
- increased hair growth or hair loss;
- breast changes;
- decreased amount of semen released during sex;
- hoarse or deepened voice, sore throat;
- flushing (warmth, redness, or tingly feeling);
- changes in your menstrual periods;
- unusual vaginal bleeding or spotting;
- vaginal dryness, discomfort, or itching.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Getting the most from your treatment
- Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. Your doctor may want you to have some blood tests during this treatment.
- It is important that you do not become pregnant while you are on Bonzol. If appropriate, you and your partner should use a non-hormonal method of contraception, such as a condom. This is because hormonal methods (such as 'the pill' or 'mini pill') will not work. Speak with your doctor if you need further advice about what methods of contraception are suitable for you to use.
- It is best not to drink alcohol while you are on Bonzol. This is because drinking alcohol while taking Bonzol could make you feel sick or short of breath.
Other progesterone derivatives
Bonzol (Danol) is a derivative of the progestogen, ethisterone. It has partial agonist androgen activity and is described as an ‘impeded’ androgen; it has little progestogen activity. It is a relatively selective inhibitor of pituitary gonadotrophin secretion (LH, FSH) affecting the surge in the mid-menstrual cycle more than basal secretion. This reduces ovarian function, which leads to atrophic changes in endometrium, both uterine and elsewhere (ectopic), i.e. endometriosis. In males it reduces spermatogenesis. Unwanted androgenic effects occur in women (acne, hirsutism and, rarely, enlargement of the clitoris).
It is used chiefly for: endometriosis, fibrocystic mastitis, gynaecomastia, precocious puberty, menorrhagia and hereditary angioedema (see p. 611 ).