Bonyl tablets


  • Active Ingredient: Naproxen
  • 500 mg, 250 mg
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What is Bonyl?

The active ingredient of Bonyl brand is naproxen. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). Naproxen works by reducing hormones that cause inflammation and pain in the body. C14H14O3 M.W. 230.26 Naproxen has a molecular weight of 230.26 and a molecular formula of C14H14O3. Naproxen USP is an odorless, white to off-white crystalline substance powder. It is lipid-soluble, practically insoluble in water, soluable in alcohol and in methanol at low pH and freely soluble in water at high pH. The octanol/water partition coefficient of Naproxen at pH 7.4 is 1.6 to 1.8. Naproxen Oral Suspension USP for oral administration contains 125 mg Naproxen USP per 5 mL and the following inactive ingredients: FD&C Yellow #6, fumaric acid, imitation orange flavor, imitation pineapple flavor, magnesium aluminum silicate, methylparaben, purified water, sodium chloride, sorbitol solution and sucrose. It has a sodium content of 39.3 mg/5 mL, 1.71 mEq/5 mL, with a pH range of 2.2 to 3.7.

Used for

Bonyl is used to treat diseases such as: Ankylosing Spondylitis, Aseptic Necrosis, Back Pain, Bursitis, Chronic Myofascial Pain, Costochondritis, Diffuse Idiopathic Skeletal Hyperostosis, Dysautonomia, Fever, Frozen Shoulder, Gout, Acute, Headache, Juvenile Rheumatoid Arthritis, Muscle Pain, Neck Pain, Osteoarthritis, Pain, Period Pain, Radiculopathy, Rheumatoid Arthritis, Sciatica, Spondylolisthesis, Tendonitis, Transverse Myelitis.

Side Effect

Possible side effects of Bonyl include: lightheadedness; disturbed color perception; pinpoint red or purple spots on the skin; Bloating; night blindness.

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Why is this medication prescribed?

Prescription Bonyl is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints), rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), juvenile arthritis (a form of joint disease in children), and ankylosing spondylitis (arthritis that mainly affects the spine). Prescription Bonyl tablets, extended-release tablets, and suspension are also used to relieve shoulder pain caused by bursitis (inflammation of a fluid-filled sac in the shoulder joint), tendinitis (inflammation of the tissue that connects muscle to bone), gouty arthritis (attacks of joint pain caused by a build-up of certain substances in the joints), and pain from other causes, including menstrual pain (pain that happens before or during a menstrual period). Nonprescription Bonyl is used to reduce fever and to relieve mild pain from headaches, muscle aches, arthritis, menstrual periods, the common cold, toothaches, and backaches. Bonyl is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation.

Missed Dose of Bonyl

If you miss a dose, take it as soon as you think of it, but do not take two doses at the same time, and do not take extra doses.

If you are close to your dose time, take your normal dose.

If you are well past your dose time, skip the missed dose and just wait until your next scheduled dose.

Risks of Ibuprofen vs. Bonyl

Both ibuprofen and Bonyl have a lower risk of bleeding compared to other NSAIDs, but both should be taken with food or milk to reduce the risk of stomach upset. Risks are similar, and neither should be taken during pregnancy. People who have cardiovascular disease, particularly those who recently had a heart attack or cardiac bypass surgery, are at the greatest risk for cardiovascular adverse events associated with NSAIDs, warns the FDA. Physicians frequently recommend acetaminophen as an OTC pain reliever for patients with cardiovascular issues.


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1. About Bonyl

Bonyl is a medicine that reduces inflammation and pain in joints and muscles.

It's used to treat diseases of joints, such as rheumatoid arthritis, osteoarthritis and gout.

It's also used for period pain and muscle and bone disorders, such as back pain and sprains and strains.

Bonyl is available on prescription as tablets or as a liquid that you drink. You can buy it without a prescription from a pharmacy for period pain.

Brands include Feminax Ultra, Period Pain Reliever and Boots Period Pain Relief.

Bonyl can only be taken by children when it's prescribed for them.

FDA warnings

  • This drug has black box warnings. These are the most serious warnings from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients about drug effects that may be dangerous.
  • Bonyl may increase the risk of heart disease. Using Bonyl in the long term or at high doses increases your risk. People with heart disease or risk factors for heart disease, such as high blood pressure, also have higher risk. Bonyl shouldn’t be used for pain before or after heart bypass surgery. Doing so may increase your risk of a heart attack and stroke.
  • Bonyl may cause ulcers and bleeding in your stomach and intestines. This can happen at any time during treatment and may occur without symptoms. This effect can result in death. You’re at higher risk if you’re older than 65 years.

How it works

Prescription Bonyl oral tablets belong to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs help reduce pain, inflammation, and fever. It isn’t fully understood how this medication works to decrease pain. It may help reduce swelling by lowering levels of prostaglandin. This is a hormone-like substance that usually causes inflammation.

Prescription Bonyl oral tablets may cause drowsiness. You shouldn’t drive, use machinery, or do other activities that require alertness until you know you can function normally. This drug can also cause other side effects.

Other uses for this medicine

Bonyl is also sometimes used to treat Paget's disease of bone (a condition in which the bones become abnormally thick, fragile, and misshapen) and Bartter syndrome (a condition in which the body does not absorb enough potassium, causing muscle cramping and weakness and other symptoms). Talk to your doctor about the risks of using this medication for your condition.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Q: Can Bonyl 500 mg or high blood pressure medications cause weight gain?

A: Bonyl does not appear to cause weight gain in patients taking the medication. High blood pressure medications do not generally cause weight gain, but if you are experiencing a sudden weight change you should consult your physician to rule out fluid retention.

Alcohol and Bonyl

Avoid drinking alcohol while taking Bonyl.

Drinking alcohol and taking Bonyl increases the chance of developing a stomach ulcer or having gastrointestinal bleeding.

8. Pregnancy and breastfeeding

Bonyl isn't normally recommended in pregnancy - especially if you're 30 or more weeks - unless it's prescribed by a doctor.

This is because there might be a link between taking Bonyl in pregnancy and some birth defects, in particular damage to the baby's heart and blood vessels.

There may also be a link between taking Bonyl in early pregnancy and miscarriage.

Talk to your doctor about the benefits and possible harms of taking Bonyl.

It'll depend on how many weeks pregnant you are and the reason you need to take the medicine. There may be other treatments that are safer for you.

Paracetamol is usually recommended as the first choice of painkiller for pregnant women.

For more information about how Bonyl can affect you and your baby during pregnancy, read this leaflet on the Best Use of Medicines in Pregnancy (BUMPS) website.

Generic Name: Bonyl (na PROX en)Brand Names: Aleve, EC-Naprosyn, Flanax Pain Reliever, M >Naprosyn, Anaprox, Anaprox-DS, Bonyl Sodium, Aleve Caplet, Aleve Gelcap, Aleve Easy Open Arthritis

Bonyl is also available in combination with other medications under the following brand names: Aleve PM, Aleve-D Sinus and Cold, Treximet, and Vimovo

Medically reviewed by Kaci Durbin, MD Last updated on Dec 3, 2018.

Q: What is the difference between Bonyl and Aleve? Is it true that you can't take both together?

A: Aleve is a brand name of Bonyl, so they are the same. Bonyl is in a class of drugs called non-steroidal anti-inflammatory drugs (NSAIDs). NSAIDs work by reducing hormones that cause inflammation and pain in the body. Bonyl is used to treat pain or inflammation caused by conditions such as arthritis, ankylosing spondylitis, tendonitis, bursitis, gout, or menstrual cramps. Common side effects of Bonyl include upset stomach, mild heartburn, stomach pain, diarrhea, constipation, bloating, gas, dizziness, headache, nervousness, blurred vision, and ringing in the ears. This is not a complete list of side effects that can occur with Bonyl. Using NSAIDs can increase the risk of serious side effects, such as heart attack, stroke, and bleeding from the digestive tract. The risk of heart attack and stroke increase with long-term use of NSAIDS. Seek emergency medical attention if you experience chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance. Bleeding from the digestive tract can happen at any time during treatment with an NSAID. Contact your doctor right away if you have any symptoms of bleeding from the digestive tract, such as black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. Always read and follow the complete directions and warnings on over-the-counter medicines and discuss their use with your health care provider before taking them. For more specific information, consult with your doctor or local pharmacist for guidance based on your health status and current medications. Sarah Lewis, PharmD

How to use Bonyl

Read the Medication Guide provided by your pharmacist before you start using Bonyl and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually twice daily with or without food. Swallow this medication whole. Do not break, crush, or chew the tablets. Doing so can release the drug too quickly, increasing the risk of side effects. Take this medication with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise. Do not lie down for at least 10 minutes after taking this drug.

The dosage is based on your medical condition and response to treatment. To reduce your risk of stomach bleeding and other side effects, take this medication at the lowest effective dose for the shortest possible time. Do not increase your dose or take this drug more often than directed. For ongoing conditions such as arthritis, continue taking this medication as directed by your doctor.

For certain conditions (such as arthritis), it may take up to two weeks of taking this drug regularly until you get the full benefit.

Tell your doctor if your condition does not improve or if it worsens.


If you think you may have symptoms of a stomach ulcer, stop taking Bonyl and contact your doctor.

It's been said that taking anti-inflammatory medicines increases the chances of getting heart failure.

But the risk is very small for most people.

If you find you need to take Bonyl very often or you're taking doses higher than recommended, talk to your doctor about your pain.

Some anti-inflammatory medicines are less risky than others. Your doctor will be able to help you decide which is the best one for you.

Bonyl is safe for occasional use when taken as advised by a doctor.

If you have problems with your kidney function, talk to your doctor about the best anti-inflammatory to take.

NSAIDs may cause an increased risk of sudden kidney failure and even progressive kidney damage.

It's thought some anti-inflammatory medicines, including Bonyl, can increase the chance of you getting an irregular heartbeat (such as atrial fibrillation or atrial flutter).

But the chances of getting an irregular heartbeat is small and not enough to recommend people stop taking these medicines.

If you're prescribed Bonyl for a long-term condition, keep taking it and talk to your doctor if you're worried.

If you buy Bonyl from a shop, occasional doses or short courses (2 or 3 days) are safe.

It's been reported that women taking some anti-inflammatory medicines, including Bonyl, twice a week for more than a year have a higher chance of losing their hearing.

But there's no proof that Bonyl and similar anti-inflammatory medicines cause hearing loss.

Hearing loss is common as people get older.

There are ways to protect your hearing - for example, limiting your exposure to loud noise, wearing hearing protection in noisy places, and keeping the volume down on personal headphones.

If you find you have to take Bonyl several days a week, talk to your doctor about what's causing your pain and whether there are better ways to manage it.

Taking anti-inflammatory medicines, like Bonyl, in large doses or for a long time can affect ovulation in women. This may make it more difficult to get pregnant.

Do not take Bonyl if you're trying to get pregnant or you're having tests for infertility.

Paracetamol is a better painkiller in these situations.

There's no firm evidence to suggest that taking Bonyl will reduce fertility in men.

Bonyl doesn't affect any type of contraception, including the combined pill or emergency contraception.

Yes, you can drink alcohol while taking Bonyl. But drinking too much alcohol may irritate your stomach.

What should I avoid while taking Bonyl?

Avoid drinking alcohol. It may increase your risk of stomach bleeding.

Avoid taking aspirin while you are taking Bonyl.

Ask your doctor before taking any other medication for pain, arthritis, fever, or swelling. Many medicines available over the counter contain aspirin, salicylates, or other medicines similar to Bonyl (such as ibuprofen or ketoprofen). Taking certain products together can cause you to get too much of this type of medication.

Ask your doctor before using an antacid, and use only the type your doctor recommends. Some antacids can make it harder for your body to absorb Bonyl.

Bonyl Interactions

Always tell your doctor or pharmacist about any drugs you take, including other prescription drugs, other OTC drugs, and any vitamins, dietary supplements or herbal remedies.

Certain drugs are known to interact with Bonyl and may cause problems:

  • Bonyl may interact with several types of blood pressure medications and make them less effective.
  • Some types of antacids medications may make Bonyl less effective.
  • Bonyl should be taken very carefully with other NSAIDs, including aspirin.
  • Bonyl may reduce the effectiveness of some diuretics.
  • Bonyl may enhance the toxicity of lithium and increase the risk for lithium side effects.
  • Bonyl may increase the level of the drug methotrexate and increase the risk for methotrexate side effects.
  • The blood thinner warfarin may be more likely to cause GI (stomach) bleeding when combined with Bonyl.
  • Bonyl may be more likely to cause GI bleeding when combined with antidepressant drugs called SSRIs.

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