• Active Ingredient: Medroxyprogesterone
  • 10 mg, 5 mg, 2.5 mg
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What is Apo-Medroxy?

The active ingredient of Apo-Medroxy brand is medroxyprogesterone. Medroxyprogesterone is a progestin (a form of progesterone), a female hormone that helps regulate ovulation (the release of an egg from an ovary) and menstrual periods. Each Medroxyprogesterone acetate tablet for oral administration contains 2.5 mg, 5 mg or 10 mg of Medroxyprogesterone acetate and the following inactive ingredients: calcium stearate, corn starch, lactose, mineral oil, sorbic acid, sucrose, and talc. The 2.5 mg tablet contains FD&C Yellow No. 6.

Used for

Apo-Medroxy is used to treat diseases such as: Abnormal Uterine Bleeding, Amenorrhea, Birth Control, Endometrial Cancer, Endometrial Hyperplasia, Prophylaxis, Endometriosis, Gender Dysphoria, Renal Cell Carcinoma.

Side Effect

Possible side effects of Apo-Medroxy include: weight gain; blurred vision; Abdominal or stomach pain; nervousness; changes in skin color.

How to Buy Apo-Medroxy online?

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What should I avoid while taking Apo-Medroxy?

Avoid smoking while you are taking this medicine. Smoking greatly increases your risk of blood clots.

This medicine can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

  • had a stroke or heart attack in the past year.
  • currently have or have had blood clots.
  • currently have or have had liver problems.
  • Tell your healthcare provider if you think that you may be pregnant or having a miscarriage. There may be an increased risk of minor birth defects in children whose mothers take this drug during the first 4 months of pregnancy. If you take Apo-Medroxy and later find out you were pregnant when you took it, be sure to discuss this with your doctor as soon as possible.
  • Apo-Medroxy should not be used as a test for pregnancy.

Provera Interactions

Avoid smoking while you are taking this medicine. Smoking greatly increases your risk of blood clots.

This medicine can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

Other drugs may interact with Apo-Medroxy, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

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The following side effects have been reported with the use of Apo-Medroxy alone:

  • Breast tenderness
  • Breast milk secretion
  • Breakthrough bleeding
  • Spotting (minor vaginal bleeding)
  • Irregular periods
  • Amenorrhea (absence of menstrual periods)
  • Vaginal secretions
  • Headaches
  • Nervousness
  • Dizziness
  • Depression
  • Insomnia, sleepiness, fatigue
  • Premenstrual syndrome-like symptoms
  • Thrombophlebitis (inflamed veins)
  • Blood clot
  • Itching, hives, skin rash
  • Acne
  • Hair loss, hair growth
  • Abdominal discomfort
  • Nausea
  • Bloating
  • Fever
  • Increase in weight
  • Swelling
  • Changes in vision and sensitivity to contact lenses

The following side effects have been reported with the use of Apo-Medroxy with an estrogen.

Side effects are grouped by how serious they are and how often they happen when you are treated:

Serious but less common side effects of estrogen include:

  • Breast cancer
  • Cancer of the uterus
  • Stroke
  • Heart attack
  • Blood clots
  • Dementia
  • Gallbladder disease
  • Ovarian cancer
  • High blood pressure
  • Liver problems
  • High blood sugar
  • Enlargement of benign tumors of the uterus ("fibroids")

Some of the warning signs of these serious side effects include:

  • Breast lumps
  • Unusual vaginal bleeding
  • Dizziness and faintness
  • Changes in speech
  • Severe headaches
  • Chest pain
  • Shortness of breath
  • Pains in your legs
  • Changes in vision
  • Vomiting
  • Yellowing of the skin, eyes or nail beds

Call your healthcare provider right away if you get any of these warning signs, or any other unusual symptom that concerns you.

Less serious but common side effects include:

  • Headache
  • Breast pain
  • Irregular vaginal bleeding or spotting
  • Stomach/abdominal cramps, bloating
  • Nausea and vomiting
  • Hair loss
  • Fluid retention
  • Vaginal yeast infection

These are not all the possible side effects of Apo-Medroxy with or without estrogen. For more information, ask your healthcare provider or pharmacist.

What is the most important information I should know about Apo-Medroxy?

You should not use this medicine if you are pregnant, or if you have liver disease, a hormone-related cancer such as breast or uterine cancer, a history of stroke or blood clot, or abnormal vaginal bleeding that has not been checked by a doctor.

Apo-Medroxy should not be used to prevent heart disease, stroke, or dementia. This medicine may actually increase your risk of developing these conditions. Long-term use of Apo-Medroxy may increase your risk of breast cancer, heart attack, stroke, or blood clot. Talk with your doctor about your individual risk.

Apo-Medroxy may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • breasts that are tender or produce a liquid
  • changes in menstrual flow
  • irregular vaginal bleeding or spotting
  • acne
  • growth of hair on face
  • loss of hair on scalp
  • difficulty falling asleep or staying asleep
  • drowsiness
  • upset stomach
  • weight gain or loss

Provera Dosage

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Apo-Medroxy is usually given for only a few days in a row each month. You may need to start taking the medication on a certain day of your menstrual cycle, depending on why you are taking Apo-Medroxy. Follow your doctor's instructions.

Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using Apo-Medroxy.

This medicine can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are taking Apo-Medroxy.

Store at room temperature away from moisture and heat.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Copyright 1996-2019 Cerner Multum, Inc.

Latest Update: 11/9/2018, Version: 7.03

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When it is prescribed to help problems such as heavy, painful, irregular or missed periods, it works by replacing or supplementing the naturally produced female sex hormone called progesterone.

Apo-Medroxy is also used for endometriosis. Endometriosis is a condition where tissue that normally lines the inside of your womb (uterus) is found elsewhere in your body, often in the pelvic area or tummy (abdomen). The cells in this tissue need oestrogen (another female sex hormone) to grow and survive. Apo-Medroxy reduces the effect of oestrogen on these cells which causes them to 'shrink'. This means the patches of endometriosis also shrink.

Apo-Medroxy is also prescribed (although at higher doses than in the conditions mentioned above) to help treat some cancers, particularly endometrial cancer.

Apo-Medroxy is also available as an injection to prevent pregnancy, and as tablets (in combination with an oestrogen) for hormone replacement therapy (HRT) during the menopause. There are other medicine leaflets available which will give you more information about Apo-Medroxy when it is used for these reasons. See the separate leaflets called Apo-Medroxy injection for contraception and Oestrogen and progestogen for HRT.

Tell your doctor if you have any of the following: high blood pressure, angina, or heart disease; had a stroke; a history of unusual bleeding or blood-clotting; liver disease; kidney disease; a personal or family history of breast cancer, uterine, or another hormone-related cancer; undiagnosed, abnormal vaginal bleeding; a history of intracranial hypertension (increased blood pressure in the head); problems with the eyes; osteoporosis; depression; migraines; diabetes; asthma; seizures or epilepsy. You may not be able to use Apo-Medroxy or you may require special monitoring during treatment if you have any of the conditions listed above.

Women who use Apo-Medroxy may lose significant bone mineral density. Bone loss is greater the longer the drug is used and may not be completely reversible. It is unknown if the use of Apo-Medroxy in adolescents or young adults will reduce bone mass and increase the risk for osteoporotic fracture in later life. Women should only use Apo-Medroxy as a long-term birth control method (longer than two years) if other birth control methods are inadequate.

If you are switching from the pill, patch or ring form of contraception to an injectable form of Apo-Medroxy contraception, the first injection should be administered within 7 days after taking the last active pill or removing the patch or ring. Similarly, contraceptive coverage can be maintained when switching from one form of injectable Apo-Medroxy to another if the next injection is given within your current scheduled dosing period. Talk to your doctor if you have any questions regarding your contraceptive coverage when switching products.

Apo-Medroxy is in the FDA pregnancy category X. This means that Apo-Medroxy is known to cause birth defects in an unborn baby. Hormonal changes during pregnancy can have serious negative effects on a developing baby. Notify your doctor immediately if you think you might be pregnant.

Additionally, this drug passes into breast milk but does not appear to affect a nursing baby. Talk to your doctor before using Apo-Medroxy if you are breast-feeding a baby.

Avoid smoking cigarettes during treatment with Apo-Medroxy. Smoking may increase the risk of developing a heart attack, stroke, or blood clot.

Apo-Medroxy contraceptive does not offer protection from sexually transmitted diseases including HIV and AIDS. Using a condom is the only way to obtain protection from these diseases.

What should I do if I forget a dose?

If a dose of Apo-Medroxy contraceptive is missed or delayed past the 3 month interval, another form of birth control should be used to ensure contraceptive protection. Contact your healthcare provider if a dose is missed or delayed.

On the other hand, contact your doctor if a dose of Apo-Medroxy is missed when being used in the treatment of cancer.

What side effects can this medication cause?

Getting the most from your treatment

  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. Also, remember to keep any routine appointments for breast screening and cervical smear tests.
  • These tablets are not for preventing pregnancy. If you need contraception you should discuss this with your doctor.
  • If you have diabetes you may need to check your blood glucose more frequently, as the tablets can affect the levels of sugar in your blood. Your doctor will advise you about this.
  • It is best to avoid smoking and drinking too much alcohol while taking Apo-Medroxy. If you are a smoker and you would like advice on how to quit, speak with your doctor or pharmacist.

Last Update: June 6, 2019 .

Desogestrel, Dydrogesterone, Levonorgestrel, Apo-Medroxy, Megestrol, Norethindrone, Norgestrel, Norgestimate, Progesterone

What other information should I know?

Keep all appointments with your doctor.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking Apo-Medroxy.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Apo-Medroxy Overview

Apo-Medroxy is a prescription hormone medication used to treat a variety of conditions including menstrual periods that have stopped or abnormal vaginal bleeding. It is also used to prevent an overgrowth of the lining of the uterus in women taking estrogen who have gone through menopause. Apo-Medroxy works by replacing progesterone hormone that the body is unable to make.

This medication comes in tablet form and is taken once daily for a certain amount of days in a row (decided by your doctor) each month. Apo-Medroxy is also available in two injectable forms that are used as long-acting birth control as well as other indications.

Common side effects include breast tenderness, spotting, and headaches.

Bone mineral density loss (injection)

  • Apo-Medroxy contraceptive injection may cause significant loss of bone mineral density
  • Bone loss is greater with increasing duration of use and may not be completely reversible
  • Unknown whether use during critical period of bone accretion (adolescence or early adulthood) will reduce peak bone mass and increase osteoporotic fracture risk in later life
  • Use for long-term (>2 years) birth control only if other contraceptive methods are inadequate or poorly tolerated

Mechanism of action

The 21-carbon synthetic progestins Apo-Medroxy and megestrol are the most closely related pharmacologically and chemically to the natural progestin, progesterone, the precursor of estrogens, androgens and adrenocortical steroids. The physiological effects of the synthetic progestins are similar to those of the other steroid hormones (see Chapter 23 ).

Progesterone and its metabolites cause nonspecific depression of the CNS, act as nonspecific sedatives and have barbiturate-like activity. They are antiandrogenic and act mainly in the medial preoptic area and the anterior hypothalamus, the areas that control male sexual behavior and urine marking. Progesterone also interferes with synthesis of estrogen receptors and suppresses the production of testosterone in the reproductive tract of intact animals. However, progestins also suppress male-like behavior in castrated cats.

The behavioral and physiological effects of progestins were initially thought to be due to inhibition of 5α-steroid reductase. However, their effects are now thought to be mediated in a number of other ways, including actions on GABAA receptors to produce effects similar to those of the benzodiazepines.

Formulations and dose rates

Apo-Medroxy Acetate and Cyproterone Acetate.

Apo-Medroxy and cyproterone reversed or arrested the progression of secondary sexual characteristics but had no apparent effect or only a small effect on final height, especially in affected girls. 562,671 Apo-Medroxy acetate inhibits gonadotropin secretion by its action on the hypothalamic GnRH pulse generator/pituitary gonadotropin unit and has a direct suppressive effect on gonadal steroidogenesis through 3β-HSD2. Apo-Medroxy acetate has glucocorticoid action and can suppress ACTH and cortisol secretion, increase appetite and lead to excessive weight gain, and induce hypertension and a cushing­oid facies and appearance.

Cyproterone acetate has been used outside the United States for the treatment of CPP with advantages and disadvantages similar to those of Apo-Medroxy acetate. Cyproterone acetate has antiandrogenic, antigonadotropic, and progestational properties. Cyproterone acetate suppresses the secretion of ACTH and the plasma concentration of cortisol. Fatigue and weakness are common side effects, probably as a consequence of secondary adrenal insufficiency. This agent lacks gluconeogenic activity and does not appear to produce cushingoid features.

The long-term effects of these agents on fertility are not known. For the treatment of CPP, Apo-Medroxy acetate and cyproterone acetate have now been replaced by the much more effective GnRH agonists; however, they may be used as backup agents for the occasional patients who develop untoward effects from GnRH agonist therapy.

Amenorrhea, Uterine Bleeding

Uterine bleeding: 5-10 mg/day PO for 5-10 days; beginning day 16 or 21 of the menstrual cycle; withdrawal bleeding may be expected within 3 to 7 days after discontinuing Apo-Medroxy

Amenorrhea, secondary: 5-10 mg/day PO for 5-10 days; may be started at any time; withdrawal bleeding may be expected within 3-7 days after discontinuing Apo-Medroxy

What other drugs will affect Apo-Medroxy?

Other drugs may interact with Apo-Medroxy, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

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