Contact with drug warning
Analpan gel can transfer to others. Make sure the gel has dried on your skin before you touch anyone else.
Bipolar disorder drug
If you take lithium with Analpan, it may increase the lithium in your body to harmful levels. Your doctor may monitor your lithium levels closely.
Q: What kind of over the counter pain relievers can I take with Analpan?
A: Analpan belongs to the class of drugs known as nonsteroidal anti-inflammatory drugs or NSAIDs. The use of Analpan with over-the-counter pain relievers would generally be limited to acetaminophen (Tylenol and others). All other over-the-counter pain relievers contain aspirin or other NSAIDs, such as ibuprofen and naproxen. The use of multiple NSAIDs is not generally recommended because of the potential for increased side effects, such as gastrointestinal upset and bleeding. Michelle McDermott, PharmD
VOLTAREN ® (Analpan sodium enteric-coated tablets)
75 mg - light pink, biconvex, triangular-shaped, enteric-coated tablets (imprinted VOLTAREN 75 on one side in black ink)
Bottles of 100 - NDC 0028-0264-01
Store at room temperature 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C to 30°C (59°F to 86°F) .
Protect from moisture.
Dispense in tight container (USP).
Distributed by: Novartis Pharmaceuticals Corporation East Hanover, NJ 07936. Revised: May 2016
Mechanism Of Action
Analpan has analgesic, anti-inflammatory, and antipyretic properties.
The mechanism of action of VOLTAREN, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2).
Analpan is a potent inhibitor of prostaglandin synthesis in vitro. Analpan concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Prostaglandins are mediators of inflammation. Because Analpan is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in peripheral tissues.
Analpan sodium administered to male and female rats at 4 mg/kg/day (approximately 0.2 times the MRHD based on BSA comparison) did not affect fertility.
Based on the mechanism of action, the use of prostaglandin-mediated NSAIDs, including VOLTAREN, may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women. Published animal studies have shown that administration of prostaglandin synthesis inhibitors has the potential to disrupt prostaglandin-mediated follicular rupture required for ovulation. Small studies in women treated with NSAIDs have also shown a reversible delay in ovulation. Consider withdrawal of NSAIDs, including VOLTAREN, in women who have difficulties conceiving or who are undergoing investigation of infertility.
Analpan hepatotoxicity is typically associated with an acute hepatitis-like histology with necrosis that may be most prominent in zone 3 (centrally). There is usually focal necrosis and inflammation, but with severe cases the injury can be confluent or submassive. Chronic hepatitis-like injury with prominence of portal inflammation, interface hepatitis and fibrosis can be found, particularly in cases with longer latency and more prolonged course. A minority of cases showed mixed hepatocellular cholestatic injury (cholestatic hepatitis) with varying degrees of inflammation. Three photomicrographs are shown.
- Gently squeeze out the tube - or press firmly and evenly on the nozzle of the dispenser - to get a small amount of gel.
- Put the gel on the painful or swollen area and slowly rub it in. It may feel cool on your skin. Wash your hands afterwards.
You'll usually use the gel 2 to 4 times a day, depending on how strong it is. Check the packaging for more information or speak to your pharmacist.
If you're using the gel twice a day, use it once in the morning and once in the evening. If you're using it 3 or 4 times a day, wait at least 4 hours before putting on any more.