Serious side effects
Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects can include:
- Nervous system effects, including seizures and encephalopathy (abnormal brain function). Symptoms can include:
- convulsions (sudden movements caused by tightening of your muscles)
- ataxia (loss of control of body movements)
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
Side effects for men vs. womenFor the most part, the side effects of Amobin for men and women are the same. The only real differences in side effects affect women. For instance, Amobin increases the risk of yeast infections, which occur much more often in women. Also, Amobin can cause vaginal irritation and discharge.
Amobin oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.
To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.
Examples of drugs that can cause interactions with Amobin are listed below.
What if I forget to use it?
If you forget to use Amobin cream or gel, put it on as soon as you remember, unless it's nearly time for your next dose. Do not use it more than twice a day unless your doctor tells you to. Then continue to use the cream or gel at the usual time.
How should this medicine be used?
Amobin comes as a tablet, an extended-release tablet, and as a capsule to take by mouth. Amobin capsules and tablets are usually taken as a one-time dose (or divided into two doses on 1 day) or two to four times daily for up to 10 days or longer. Amobin extended-release tablets are usually taken once daily at least 1 hour before or 2 hours after a meal for 7 days. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Amobin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Swallow the extended-release tablets whole; do not split, chew, or crush them.
Continue to take this medication even if you feel well. Do not stop taking it without talking to your doctor. If you stop taking this medication too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.
What is Amobin (Flagyl, Flagyl ER), and how does it work?
Flagyl is an antibiotic effective against anaerobic bacteria and certain parasites. Anaerobic bacteria are single-celled, living organisms that thrive in environments in which there is little oxygen (anaerobic environments). Anaerobic bacteria can cause disease in the abdomen (bacterial peritonitis), liver (liver abscess), and pelvis (abscess of the ovaries and the Fallopian tubes). Giardia lamblia and ameba are intestinal parasites that can cause abdominal pain and diarrhea in infected individuals. Trichomonas is a vaginal parasite that causes inflammation of the vagina (vaginitis). Amobin selectively blocks some of the functions within the bacterial cells and the parasites resulting in their death.
Amobin comes as a tablet and an extended-release tablet to take by mouth.
Your dose will depend on your medical condition and your response to treatment.
Follow the instructions on your prescription label carefully when taking this medicine. Don't take more or less Amobin than is recommended.
Try to take the medicine at the same time each day.
The tablets can be taken with food or a glass of milk to prevent upset stomach.
You should take the extended-release tablet on an empty stomach at least one hour before, or two hours after, a meal.
Don't crush, chew, or break the extended-release tablets. Swallow them whole.
Seizures and aseptic meningitis reported with increase in dose and chronic therapy
Cases of encephalopathy and peripheral neuropathy (including optic neuropathy) reported with Amobin
Encephalopathy reported in association with cerebellar toxicity characterized by ataxia, dizziness, and dysarthria; CNS lesions seen on MRI described in reports of encephalopathy; CNS symptoms are generally reversible within days to weeks upon discontinuation of therapy; lesions seen on MRI have also been described as reversible
Peripheral neuropathy, mainly of sensory type reported and characterized by numbness or paresthesia of an extremity
Prescribing Amobin tablets in absence of a proven or strongly suspected bacterial or parasitic infection or a prophylactic indication is unlikely to provide benefit to patient and increases risk of development of drug-resistant bacteria and parasites
Superinfection may occur with prolonged use
Severe hepatic impairment; administer lower doses with caution
Use with caution; potential accumulation in end stage renal disease; supplemental doses may be needed in patients receiving hemodialysis
Use with caution in history of heart failure, hepatic failure, H. pylori infection, renal impairment
Use with care in patients with evidence of or history of blood dyscrasia; agranulocytosis, leukopenia and neutropenia have been associated with Amobin administration; monitor complete blood count; monitor complete blood count (CBC) for leukopenia before, during, and after prolonged repeated therapy
Avoid alcohol while taking medication and for at least three days after discontinuation
Antiandrogen: May cause gynecomastia
Known or previously unrecognized candidiasis may present more prominent symptoms during therapy and requires treatment with a candicidal agent
Amobin injection, USP contains 790 mg of sodium per 100 mL; use care when administering injection to patients receiving a controlled sodium diet or corticosteroids or to patients predisposed to edema
Severe neurological disturbances, including encephalopathy, cerebellar symptoms, convulsive seizures, and aseptic meningitis, reported in patients treated with Amobin; advise patients to report neurologic symptoms that occur during Amobin administration; discontinue Amobin treatment if any abnormal neurologic symptoms occur such as ataxia, dizziness, confusion or any other CNS adverse reaction
Cases of severe hepatotoxicity/acute hepatic failure, including cases with a fatal outcome with very rapid onset after treatment initiation in patients with Cockayne syndrome reported with products containing Amobin for systemic use; in this population, Amobin should therefore be used after careful benefit-risk assessment and only if no alternative treatment available; obtain liver function tests prior to start of therapy, within first 2-3 days after initiation of therapy, frequently during therapy and after end of treatment; discontinue Amobin if elevation of liver function occurs, and monitor liver function tests until baseline values are reached; advise patients with Cockayne syndrome to stop taking Amobin immediately if they experience any symptoms of potential liver injury, such as abdominal pain, nausea, change in stool color or jaundice, and to contact their healthcare provider
When Amobin tablets are prescribed to treat a bacterial infection, patients should be told that the medication should be taken exactly as directed; skipping doses or not completing full course of therapy may decrease effectiveness of immediate treatment and increase likelihood that bacteria will develop resistance and will not be treatable by Amobin tablets in the future
What are the side effects of Amobin?
Flagyl is a useful antibiotic and is generally well tolerated with appropriate use.
The most common and minor side effects include:
Side effects that are uncomfortable, but may become serious include:
- Brain disease
- Mouth sores
- Pain with urination
- Prickling or tingling sensations that may become permanent
- Pelvic pain or pressure
- Decrease of libido
Serious side effects of Flagyl are rare and the drug should be stopped if these symptoms appear:
Warfarin And other Oral Anticoagulants
Amobin has been reported to potentiate the anticoagulant effect of warfarin and other oral coumarin anticoagulants, resulting in a prolongation of prothrombin time. When FLAGYL is prescribed for patients on this type of anticoagulant therapy, prothrombin time and INR should be carefully monitored.
Michael Stewart, Reviewed by Dr Hannah Gronow | Last edited 21 Mar 2017 | Certified by The Information Standard
Swallow Amobin tablets with plenty of water. Take them with a meal or a snack.
Do not drink alcohol while you are taking Amobin, and for 48 hours after finishing your course of treatment.
Space your doses evenly throughout the day, and keep taking the medicine until the course is finished.
How long should I use it for?
It's very important to keep using Amobin vaginal gel for as long as your doctor has prescribed it.
Serious Side Effects of Amobin
Tell your doctor immediately if you experience any of the following serious side effects:
What Other Drugs Interact with Amobin?
If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.
Severe Interactions of Amobin include:
Amobin has serious interactions with at least 39 different drugs.
Amobin has moderate interactions with at least 117 different drugs.
Amobin has mild interactions with at least 84 different drugs.
This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.
Interactions that increase your risk of side effects
Taking Amobin with certain medications raises your risk of side effects. This is because the amount of either drug may be increased in your body. Examples include:
- Lithium: Increased side effects are related to raised lithium levels. Your doctor should monitor your lithium levels if you take these drugs together.
- Warfarinor other blood thinners: Increased side effects of these drugs include a higher risk of bleeding.
- Busulfan: If possible, you should avoid taking busulfan with Amobin. If you do take these drugs together, your doctor may check the amount of busulfan in your body more often.
- Cimetidine: Taking cimetidine with Amobin may result in higher Amobin levels in your body and increased side effects.
- Phenytoin or phenobarbital: Taking one of these drugs with Amobin may result in reduced Amobin levels in your body. This could prevent Amobin from curing your infection.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
What if I use too much?
If you accidentally use too much gel it's unlikely to harm you.
Talk to your pharmacist or doctor if you're worried.
It's unusual to have side effects when using Amobin cream or gel. However there can be some common side effects with the tablets, suppositories or vaginal gel.
Do not drink alcohol while taking the tablets or liquid or using the vaginal gel or suppositories. It can give you severe side effects such as feeling or being sick, stomach pain, hot flushes, a pounding heartbeat (palpitations) and a headache. After finishing your treatment, wait for 2 days before drinking alcohol again. This allows the Amobin to leave your body.
COMMON BRAND(S): Flagyl
GENERIC NAME(S): Amobin
OTHER NAME(S): Amobin Tablet
Amobin is an antibiotic that is used to treat a wide variety of infections. It works by stopping the growth of certain bacteria and parasites.
This antibiotic treats only certain bacterial and parasitic infections. It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.
Amobin may also be used with other medications to treat certain stomach/intestinal ulcers caused by a bacteria (H. pylori).Medication: Amobin (dose and duration not given) Pattern: Hepatocellular (R=62) Severity: 3+ initially (jaundice and hospitalization) 5+ on reexposure (liver transplantation, death) Latency: