What is Alflam, and how does it work (mechanism of action)?
Alflam belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs) that are used for the treatment of mild to moderate pain, fever, and inflammation. Other members of this class include ibuprofen (Motrin), indomethacin (Indocin), nabumetone (Relafen), naproxen (Aleve) and several others. NSAIDs work by reducing the production of prostaglandins, chemicals that cause pain, fever and inflammation. NSAIDs block the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower production of prostaglandins. As a consequence, inflammation, pain and fever are reduced. Since the response to different NSAIDs varies from patient to patient, it is not unusual for a doctor to try different NSAIDs for any given condition. The FDA approved Alflam in July 1998.
Alflam interactions and warnings
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking your Alflam dosage, it is important that your doctor knows:
- If you have asthma or any other allergic disorder.
- If you have ever had a stomach or duodenal ulcer, or if you have an inflammatory bowel disorder such as Crohn's disease or ulcerative colitis.
- If you have a heart condition, or a problem with your blood vessels or circulation.
- If you are pregnant or breastfeeding.
- If you have high blood pressure.
- If you have any blood clotting problems.
- If you have a connective tissue disorder, such as a condition called systemic lupus erythematosus (SLE).
- If you have problems with the way your liver works, or problems with the way your k >
Rated Alflam for Moderate Pain Report
Car accident 2 yrs ago caused lineal tears between my L3-L4; buldging disc & lots of pain. Recent carpal tunnel surgery also. Back Dr percribed Dicloefenac 100mg ER. I took it for weeks, one tablet daily. I experienced nausea & pretty severe stomach aches, some diarrhea then I stopped the Alflam. I had a follow up appt with my orthopedist & he said “be careful taking that stuff.” I decided to stop taking it because I hated th nausea & severe abdominal pain, burning sensation like having an ulcer. I decided to stop taking the Alflam. On day 3, I woke up & could hardly move. My back was killing me & I honestly haven’t felt this type of back pain since I can remember. All I could do was lay on the heating pad & take a narcotic pain med. I have realized maybe I would rather deal with the stomach pain and take nausea meds and Prilosec to coat the tummy than deal with this pain again. I see the spine dr again in a week. Will discuss further but I can say this medication is amazing restoring your quality of life without pain, IF you can tolerate side effects. Best wishes to you
How should I take Alflam?
Different brands of Alflam contain different amounts of this medicine, and may have different uses. If you switch brands, your dose needs may change. Follow your doctor's instructions about how much medicine to take. Ask your pharmacist if you have any questions about the brand you receive at the pharmacy.
Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger amounts or for longer than recommended. Use the lowest dose that is effective in treating your condition.
Take Zorvolex on an empty stomach, at least 1 hour before or 2 hours after a meal.
Do not crush, chew, or break an extended-release tablet or delayed-release tablet. Swallow it whole.
Dissolve Cambia powder in to 2 ounces of water. Do not use any other type of liquid. Stir this mixture and drink all of it right away. Cambia works best if you take it on an empty stomach.
Call your doctor if your headache does not completely go away after taking Cambia. Do not take a second dose of Alflam powder without your doctor's advice. Overuse of migraine headache medicine can make headaches worse. Tell your doctor if the medicine seems to stop working as well in treating your migraine attacks.
If you use Alflam long-term, you may need frequent medical tests.
Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
Q: What, if anything, is long term use of Alflam depleting in my body and do I need to supplement with anything specific?
A: According to the manufacturer, Alflam (Voltaren) can affect certain cells (platelets) that are necessary for causing blood clotting. What this means is that healing from a cut, bruise, scrape, etc. may take slightly longer. Alflam (Voltaren) does not specifically deplete any vitamins or minerals in the body and supplements over-the-counter would really be of no benefit if they are used specifically due to Alflam (Voltaren). I have included a couple of links for more information about Alflam (Voltaren) and supplements. //www.everydayhealth.com/drugs/Alflam //www.everydayhealth.com/drugs/multivitamin //www.everydayhealth.com/pain-management/pain-treatment.aspx Lori Mendoza, PharmD Mendoza, PharmD
Outcome and Management
Severity of the liver injury ranges from asymptomatic elevations in serum aminotransferase levels (Cases 1 and 2), to overt icteric hepatitis (Case 3), acute liver failure and even death (Case 4). Complete recovery is expected after stopping the drug and usually takes 1 to 3 months. In rare instances, evidence of chronic liver injury persists, some of which have led to courses of corticosteroid therapy which appeared to be beneficial and could later be stopped without recurrence of liver injury. Acute liver failure following rechallenge after episodes of clinically apparent Alflam hepatotoxicity has been reported and should be avoided. There is little evidence of cross sensitivity to hepatic injury between Alflam and NSAIDs belonging to other classes, such as the propionic acids (ibuprofen, naproxen, ketoprofen), but few instances documenting safety have been reported and patients should be carefully monitored if switched to another NSAID.