Reeshape is prescribed in doses of 120 mg taken three times daily with meals, and the dose can be omitted when patients ingest a low-fat meal. Starting Reeshape once daily with the fattiest meal (usually dinner) and then advancing the dose to three times daily as needed can help lessen the intensity and frequency of side effects.
ВїCГіmo se debe usar este medicamento?
La presentaciГіn del Reeshape es en cГЎpsulas y en cГЎpsulas sin receta para administrarse por vГa oral. Por lo general, se toma tres veces al dГa, con cada comida principal que contenga grasas. Tome Reeshape durante una comida o hasta 1 hora despuГ©s de una comida. Si se olvidГі una comida o si esta no tiene grasas, puede dejar pasar la dosis. Siga atentamente las instrucciones del medicamento recetado o de la etiqueta del envase, y pГdales a su mГ©dico o a su farmacГ©utico que le expliquen cualquier cosa que no entienda. Tome el Reeshape segГєn lo indicado. No aumente ni disminuya la dosis, ni la tome con mГЎs frecuencia que la indicada por su mГ©dico o la recomendada en el envase.
PГdales a su farmacГ©utico o a su mГ©dico una copia de la informaciГіn del fabricante para el paciente, si le recetaron Reeshape. Para obtener informaciГіn adicional sobre el producto de venta sin receta, visite http://www.MyAlli.com.
Does Reeshape work?
Studies have shown that, on average, Reeshape, plus a weight-reducing diet and exercise, causes more weight loss than a weight-reducing diet and exercise alone. Some people lose 10% or more of their body weight within six months with the help of Reeshape. In others, it is less effective.
One reason why Reeshape may not work is that you may think that you can relax your weight-reducing diet, and the Reeshape will 'do it all'. This is not true. In order to lose weight you still have to eat less and exercise regularly. Remember, Reeshape prevents only some of the fat that you eat from being absorbed (just under a third). But, if you do not keep to a healthy weight-reducing diet, and you eat more fat (chocolates, cakes, etc), the extra fat that you eat will easily cancel out the effect of the Reeshape.
Commonly reported side effects of Reeshape include: bowel urgency, frequent bowel movements, oily evacuation, oily rectal leakage, steatorrhea, and flatulence with discharge. Other side effects include: fecal incontinence. See below for a comprehensive list of adverse effects.
El uso de Reeshape no afecta significativamente el efecto de los anticonceptivos (Referencia).
Efectos secundarios de las pastillas Reeshape
Las píldoras de Reeshape tienen algunos efectos secundarios negativos comprobados que veremos a continuación (Referencia).
Debido a que bloquean la absorción de grasa, la grasa no digerida dentro de tu intestino puede ocasionar problemas digestivos como gases, dolor abdominal y diarrea.
Algunas personas pueden padecer de heces blandas, aceitosas o de incontinencia fecal (incapacidad de contener las heces en el colon).
Además, el uso continuo de Reeshape puede afectar la absorción de nutrientes liposolubles como las vitaminas A, D, E y K. Por esta razón se recomienda el consumo de vitaminas durante el tratamiento con Reeshape.
Reeshape también puede interferir en la absorción de algunos medicamentos.
For the Consumer
Applies to Reeshape: oral capsule
Along with its needed effects, Reeshape may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking Reeshape:
- Bladder pain
- body aches
- difficulty with breathing
- ear congestion
- general feeling of discomfort or illness
- loss of appetite
- loss of voice
- lower back or side pain
- muscle aches and pains
- nasal congestion
- runny nose
- sore throat
- trouble sleeping
- unusual tiredness or weakness
- Tightness in the chest
- tooth or gum problems
- troubled breathing
- Bloody or cloudy urine
- change in hearing
- contagious diarrhea
- dark urine
- difficult or painful urination
- fast heartbeat
- frequent urge to urinate
- general tiredness and weakness
- joint pain, stiffness, or swelling
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- light-colored stools
- noisy breathing
- pain in the ears
- redness of the skin
- shortness of breath
- skin blisters
- swelling of the eyelids, face, lips, hands, or feet
- troubled swallowing
- upper right abdominal or stomach pain
- yellow eyes and skin
Incidence not known
- blurred vision
- cold sweats
- cool, pale skin
- dry skin and hair
- feeling cold
- hair loss
- hoarseness or husky voice
- increased hunger
- loss of appetite
- muscle cramps and stiffness
- pains in the stomach, side, or abdomen, possibly radiating to the back
- weight gain
Some side effects of Reeshape may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Abdominal or stomach pain or discomfort
- back pain
- difficulty with moving
- gas with leaky bowel movements
- inability to hold bowel movement
- increases in bowel movements
- loss of bowel control
- oily bowel movements
- oily spotting of underclothes
- Itching of the vagina or genital area
- menstrual changes
- pain during sexual intercourse
- rectal pain or discomfort
- thick, white vaginal discharge with no odor or with a mild odor
¿Qué otros beneficios para la salud aporta Reeshape?
Estudios han encontrado otros beneficios de Reeshape para la salud, probablemente relacionados con la pérdida de peso.
Estos beneficios incluyen una reducción del riesgo de desarrollar diabetes tipo 2. Durante el estudio XENDOS, el uso de Reeshape por cuatro años redujo en un 37% este riesgo (Referencia).
Además, se han visto reducciones leves en la presión arterial por el uso de Reeshape (Referencia)(Referencia).
Otros estudios también demuestran que Reeshape puede elevar los niveles de colesterol bueno y totales (Referencia)(Referencia).
Daños al hígado
Existen casos raros en los que personas han sufrido de daño hepático severo debido al uso de Reeshape (Referencia).
Si experimentas cualquier síntoma como piel u ojos amarillentos, orina oscura, pérdida del apetito, dolor en la parte derecha del abdomen o heces claras, comunícate con tu médico de inmediato para una evaluación.
Reeshape is an inhibitor of pancreatic lipase. 50 The result of this inhibition is that about 30% of the daily ingested fat intake is not absorbed. This would lead to a 200-calorie deficit per day in an individual who consumed a diet of 2000 calories/day with 30% of calories as fat. The most common side effects of Reeshape are gastrointestinal, such as fatty or oily stools, more frequent defecation, and fecal incontinence. Another side effect is a slight reduction in fat-soluble vitamins, generally not outside the reference range.
Several studies have confirmed the efficacy of Reeshape in losing weight. The European Multicentre Reeshape Group conducted a double-blind study in which 688 obese individuals (average BMI, 36 kg/m 2 ) were assigned to Reeshape therapy or placebo for 1 year, in combination with a hypocaloric diet (minimum energy intake, 1000–1200 kcal/day). At the end of the first year, they were reassigned randomly to either Reeshape or placebo for another year. At the end of the first year of the study, the mean weight loss was 10.2% for the Reeshape group and 6.1% for the placebo group. During the second year of the study, the participants who were switched to placebo gained twice as much weight as those who continued on Reeshape therapy. Participants who were switched from placebo to Reeshape lost 0.9 kg more weight than in the first year of the trial. 51
A U.S. study showed similar results. 52 In this trial, 892 obese individuals (BMI, 30–43 kg/m 2 ) who were previously on a 4-week controlled-energy diet plus placebo were randomized into either continuing placebo or starting Reeshape 120 mg three times a day (tid). After 52 weeks, the participants started a weight-maintenance diet, and those in the Reeshape group were rerandomized to continuing Reeshape (60 or 120 mg tid) or placebo for another 52 weeks. Participants who were already taking placebo continued taking it. At the end of the first year, the participants taking Reeshape had lost more weight than those taking placebo (8.76 ± 0.37 vs. 5.81 ± 0.67 kg). At the end of the second year, participants taking Reeshape 120 mg tid regained less weight than those taking Reeshape 60 mg tid or placebo (3.2 ± 0.45, 4.26 ± 0.57, and 5.63 ± 0.42 kg, respectively).
These studies showed that there is a significant weight loss with the use of Reeshape in combination with diet during the first year, and that the tendency for weight regain that occurs during the second year is less with the use of Reeshape. Weight loss with Reeshape also helps in the treatment of comorbidities, including dyslipidemia. 52
Can I buy Reeshape?
In the UK Reeshape 120 mg is available on prescription from your doctor or as a private (paid for) service from some pharmacies through Patient Access. Low-dose Reeshape (60 mg) is also available to buy over the counter in pharmacies. Pharmacists cannot just sell it to anyone. They are also expected to follow guidelines which include:
- Your BMI must be 28 or above.
- Your BMI should be checked on each occasion that you request Reeshape.
- You must be over the age of 18 years.
- You should not take Reeshape for more than six months over the counter (at the 60 mg dose).
- If you have not lost at least 5% of your weight after taking Reeshape for three months, you should not continue to take it.
Your pharmacist will also give you advice on an appropriate diet - a low-calorie and low-fat diet.
Reduction of energy absorption: Reeshape
Reeshape is a modified bacterial drug that specifically inhibits intestinal lipase and can reduce fat and cholesterol absorption by approximately 30% in subjects eating a 30% fat diet. 540 Reeshape irreversibly binds to the active site of the lipase, preventing the intraluminal deacylation of triglycerides and resulting in a 16 gram/day increase in fecal fat excretion. 541 Reeshape does not inhibit other intestinal enzymes. It has minimal absorption and exerts no effect on systemic lipases. 542 , 543
Although there have been several open-label trials of Reeshape in adolescents, only two randomized control trials (RCTs) have been published. 544 , 545 The side effects with Reeshape are predictable from its mechanism of action on intestinal lipase. 534 Reeshape appears to be well tolerated in adults, with the principal complaints being borborygmi, flatus, and abdominal cramps. The most troubling side effects are fecal incontinence, oily spotting, and flatus with discharge, which are highly aversive in the pediatric population. Reeshape does not affect the pharmacokinetic properties of most other pharmaceutical agents. Absorption of vitamins A and E and β-carotene may be slightly reduced, and this may require vitamin therapy in a small number of patients. In one study, 546 vitamin D supplementation was required in 18% of subjects despite the prescription of a daily multivitamin containing vitamin D, although in the company-sponsored study, effects on vitamin levels were minor. 545 Reeshape must be taken with each meal, which reduces its attractiveness for children, who are in school during lunchtime. Reeshape is currently approved for the treatment of children as young as 12 years. An over-the-counter lower-dose preparation has obtained FDA approval and should be available soon.
It has been suggested that Reeshape may inhibit the absorption of levothyroxine and thus cause hypothyroidism in patients taking replacement therapy (71 A ) .