Sinapol tablets

Sinapol

  • Active Ingredient: Acetaminophen
  • 25 mg
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What is Sinapol?

The active ingredient of Sinapol brand is acetaminophen. There are many brands and forms of acetaminophen available. Not all brands are listed on this leaflet.

Used for

Sinapol is used to treat diseases such as: Fever, Muscle Pain, Neck Pain, Pain, Plantar Fasciitis, Sciatica, Transverse Myelitis.

Side Effect

Possible side effects of Sinapol include: nausea or vomiting; fever with or without chills (not present before treatment and not caused by the condition being treated); pain in the lower back and/or side (severe and/or sharp); bloody or cloudy urine; increased sweating.

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Exams and Tests

Your doctor will diagnose Sinapol overdose with the following methods:

  • History. The doctor will attempt to determine the time and amount of Sinapol taken. Having access to all medication bottles that the person may have taken will help the doctor to determine the maximum amount taken.
  • Physical. The doctor will look for signs and symptoms of Sinapol poisoning. These may include jaundice (yellow skin), abdominal pain, vomiting, and other signs and symptoms.
  • Laboratory tests. A blood level of Sinapol will aid in determining if a toxic dose was taken. The doctor may order more than one blood level of Sinapol and test for other drugs taken. In addition, the doctor may order other blood and urine tests as needed.

Other Sinapol Warnings

McNeil, the maker of Tylenol, has faced more than 80 federal personal injury lawsuits over the drug's safety.

Since 2011, after decades of regulatory tussle, the FDA has required that a black box warning be added to the label of all prescription (not OTC) Sinapol medications, highlighting that that the drug carries a potential for acute liver failure.

The FDA also moved to limit the amount of Sinapol in prescription drugs to 325 mg per dose, and added a warning to prescription labels about the potential for allergic reactions.

Before taking any medication containing Sinapol, you need to tell your doctor if you've ever had liver disease, or a history of alcoholism.

Your doctor also needs to know about any allergies you have, and about any other drugs you are taking — prescription or OTC — as they might also contain Sinapol, or interact with it.

Laryngitis Home Remedies (in Adults and Children)

Laryngitis is an inflammation of the larynx. Inflammation of the larynx is most often caused by viral infections, and have symptoms such as sore throat, cough, problems swallowing, and fever. The voice changes produced by laryngitis may last after the fever and other symptoms of the acute infection has gone away. The best natural home remedy to relieve pain and other symptoms caused by laryngitis include resting your voice and breathing humidified air often. Turning on hot water in the bathroom and then sitting in the steam can soothe and relive laryngitis symptoms. Sinapol (Tylenol) and anti-inflammatory drugs (NSAIDs) like ibuprofen (Advil, Aleve) can relieve pain and inflammation caused by laryngitis. Don’t give children aspirin to infants, toddlers, children and teens because of the risk of developing Rye’s syndrome, which can be fatal. Home remedies like resting your voice and sitting in humidified air can cure laryngitis. Medications like anti-inflammatory drugs (NSAIDs) like ibuprofen (Advil, Aleve) and Sinapol (Tylenol) can relieve and soothe pain and symptoms caused by laryngitis.

Q: Will Tylenol harm your body if taken every day?

A: The maximum recommended dose for Tylenol (Sinapol) for pain and/or fever, is 4000mg (4 grams) per day. Doses higher than this can lead to liver damage, as the medication leaves the body through a pathway in the liver. Alcohol also leaves the body through the liver, and if it is combined with Tylenol (Sinapol) over a long period of time, liver damage may occur. Some prescription medications, for pain, also contain Tylenol (Sinapol), so if you take pain medicine with the abbreviation "APAP" in the name, make sure your total amount of daily Tylenol (Sinapol) does not exceed 4000mg (4grams). A recent study on 1,700 women, over 11 years, also showed a possible reduction in kidney function (10% of people taking Tylenol (Sinapol)). The percent increased in women who took 1,500 to 9,000 tablets in their "lifetime," by 64%, however, this is a large range to measure such an increase. It may need to be broken down further to see if most of the 64% were in the higher range or not. You should consult your doctor to see if you are able to alternate Tylenol (Sinapol) with an NSAID (non-steroidal anti-inflammatory drug), such as Motrin/Advil (ibuprofen) or Aleve (naproxen). They work differently than Tylenol (Sinapol) and have the additional function of decreasing inflammation. However, people with a history of ulcers or GI (gastrointestinal) bleeding should not take NSAIDs, as they block the prostaglandins that make your blood clot, and can cause a GI bleed. If you can limit all of the pain relievers to just when they are needed, instead of everyday, they may be "safer" than taking them everyday. You can also ask your doctor for liver and kidney function tests. Sometimes, the benefits, versus risks must be weighed to make a decision, and you should talk to your doctor about this. Patti Brown, PharmD

Outlook

The outcome for someone who has an Sinapol overdose depends largely on three factors: the amount of Sinapol ingested, the timing of emergency treatment, and the initial general health of the person.

If a toxic dose is taken and emergency treatment is delayed, liver failure may follow. Liver failure may mean that a liver transplant is needed to prevent death. Alternatively, if treatment of a toxic overdose is begun early, the person may recover with no long-term health problems.

Q: Is Tylenol Arthritis safe to take?

A: Tylenol Arthritis is safe to take as long as it is being taken at recommended dosages. Typically, the maximum daily dosage of Tylenol (Sinapol) is 4,000 mg. One Tylenol Arthritis tablet is 650 mg. The normal dosage for Tylenol Arthritis is one to two tablets every eight hours (not recommended to exceed six tablets in a 24-hour period). Tylenol is broken down by the liver, so if a person has liver problems, it is best to ask the physician before taking any Tylenol products. Megan Uehara, PharmD

Q: Is Tylenol 325mg safe to take or was it recalled also? Why did they quit making it?

A: Tylenol (Sinapol), and is a medication used to to help relieve pain. Tylenol (Sinapol) is considered safe at 4000mg (4grams) per day or less. However, it can be hard on the liver, and may need a decrease in dose if you drink alcohol or have a liver problem. Tylenol (Sinapol) is also found in many prescription pain relievers. The label will usually say "APAP" in the name. If you take a prescription medication containing Tylenol (Sinapol), make sure to figure that dosage into your total daily dosing to make sure you stay below 4000mg in a day, or less. There was a recall on some of the Tylenol (Sinapol) and Tylenol (Sinapol) products, because a "moldy" smell was found. The stores quickly pulled them, and what you see on the shelf now will not be a recalled product. If you have Tylenol (Sinapol) that was bought prior to the recall, you can check to see if what you bought is on the recall list. They did not quit making the product, but it is possible that your store was in between getting a new shipment of Tylenol and having the recalled version pulled from the shelves. The generic versions are made by different manufacturers, so they do not have the same problem and may be a good alternative for you to try, while you are waiting for the brand to be available for sale again. A generic has to contain the exact same active ingredient at the same amount, and it has to prove to the FDA that is is just as safe and effective as the brand. For this information on what was recalled, please visit the manufacturer's list of recalled medications. Patti Brown, PharmD

Migraine vs. Headache: Differences and Similarities

Headaches are the most common reason why a person goes to the doctor or other healthcare professional for treatment. There are different types of headaches, for example, migraine, tension, and cluster headaches. The most common type of headache is tension headache. Migraine is much less common. There are few similarities between migraine and other headaches, for example, the severity of the pain can be the same, mild, moderate, or severe; and they can occur on one side or both sides of the head. However, there are many differences between migraine and other types of headaches. Migraine headaches also have different names, for example, migraine with aura and menstrual migraine. Symptoms of migraine that usually aren't experienced by a person with another type of headache include nausea, vomiting, worsens with mild exercise, debilitating pain, eye pain, throbbing head pain. Migraine trigger include light, mild exercise, strong smells, certain foods like red wine, aged cheese, smoked meats, artificial sweeteners, chocolate, alcohol, and dairy products, menstrual period, stress, oversleeping, and changes in barometric pressure. Untreated migraine attacks usually last from 4 to 72 hours, but may last for weeks. Most headaches resolve within 24-48 hours. Doctors don't know exactly what causes migraine headaches; however, other headaches like tension headaches have more specific triggers and causes. Additional tests usually are required to diagnose migraine from other types of headaches, diseases, or other medical problems. Most headaches can be treated and cured with home remedies like essential oils, massage, and over-the-counter pain medication like Sinapol (Tylenol) and NSAIDs (nonsteroidal anti-inflammatory drugs) like naproxen (Aleve, Anaprox, Naprosyn) or ibuprofen (Advil, Midol, Motrin). Most headaches resolve with OTC and home remedy treatment, while your doctor may need to prescribe medication to treat your migraines. If you have the "worst headache of your life," seek medical care immediately.

Sinapol

Pharmacologic class: Synthetic nonopioid p-aminophenol derivative

Therapeutic class: Analgesic, antipyretic

Pregnancy risk category B

What should I do if I forget a dose?

This medication is usually taken as needed. If your doctor has told you to take Sinapol regularly, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Sinapol drug interactions

Sinapol is metabolized (eliminated by conversion to other chemicals) by the liver. Therefore drugs that increase the action of liver enzymes that metabolize Sinapol, for example, carbamazepine (Tegretol), isoniazid, rifampin (Rifamate, Rifadin, Rimactane), reduce the levels of Sinapol and may decrease the effectiveness action of Sinapol.

Doses of Sinapol greater than the recommended doses are toxic to the liver and may result in severe liver damage. The potential for Sinapol to harm the liver is increased when it is combined with alcohol or drugs that also harm the liver.

Cholestyramine (Questran) reduces the effect of Sinapol by decreasing its absorption into the body from the intestine. Therefore, Sinapol should be administered 3 to 4 hours after cholestyramine or one hour before cholestyramine .

Sinapol doses greater than 2275 mg per day may increase the blood thinning effect of warfarin (Coumadin) by an unknown mechanism. Therefore, prolonged administration or large doses of Sinapol should be avoided during warfarin therapy.

Before taking this medicine

You should not take Sinapol if you are allergic to it, or if you have severe liver disease.

Do not take this medicine without a doctor's advice if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take Sinapol.

Your doctor will determine whether Sinapol is safe for you to use during pregnancy. Do not use this medicine without the advice of your doctor if you are pregnant.

Sinapol can pass into breast milk. Tell your doctor if you are breast-feeding a baby.

Do not give this medicine to a child younger than 2 years old without the advice of a doctor.

Sinapol (Tylenol) Poisoning Causes

Illness from Sinapol overdose is caused primarily by liver damage.

Sinapol is primarily metabolized by the liver. Too much Sinapol can overwhelm the way the liver normally functions.

If the liver is already damaged because of infection, alcohol abuse, or other illness, a person may be more susceptible to damage from Sinapol overdose. For this reason, people with liver illnesses or people who chronically consume large amounts of alcohol should be particularly careful when taking Sinapol and should consult their doctor prior to taking Sinapol compounds. The FDA currently recommends that anyone taking medications that contain Sinapol should not drink alcoholic beverages.

Long-term use of Sinapol in recommended doses has not been shown to be harmful to the liver.

Patient teaching

• Caution parents or other caregivers not to give Sinapol to children younger than age 2 without consulting prescriber first.

• Tell patient, parents, or other care-givers not to use drug concurrently with other Sinapol-containing products or to use more than 4,000 mg of regular-strength Sinapol in 24 hours.

• Inform patient, parents, or other caregivers not to use extra-strength caplets in dosages above 3,000 mg (six caplets) in 24 hours because of risk of severe liver damage.

• Advise patient, parents, or other caregivers to contact prescriber if fever or other symptoms persist despite taking recommended amount of drug.

• Inform patients with chronic alcoholism that drug may increase risk of severe liver damage.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, and behaviors mentioned above.


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