Pyralgin tablets


  • Active Ingredient: Acetaminophen
  • 25 mg
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What is Pyralgin?

The active ingredient of Pyralgin brand is acetaminophen. There are many brands and forms of acetaminophen available. Not all brands are listed on this leaflet.

Used for

Pyralgin is used to treat diseases such as: Fever, Muscle Pain, Neck Pain, Pain, Plantar Fasciitis, Sciatica, Transverse Myelitis.

Side Effect

Possible side effects of Pyralgin include: pinpoint red spots on the skin; unusual tiredness or weakness; sores, ulcers, or white spots on the lips or in the mouth; loss of appetite; Diarrhea; sudden decrease in the amount of urine; sore throat (not present before treatment and not caused by the condition being treated); bloody or cloudy urine.

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Pyralgin Overdose

While considered safe and effective when taken as directed, Pyralgin is not without serious risks.

Taking more than the maximum dosage of 3,000 to 4,000 milligrams a day — even just small amounts more — can cause serious liver damage, even death, according to the FDA.

Often these overdoses are inadvertent and occur when people unknowingly take more than one Pyralgin-containing medication at the same time.

If you think you've overdosed on Pyralgin, seek medical treatment immediately, even if you don't have symptoms, as symptoms can take many days to appear.

Q: How long can I take Tylenol for before it becomes dangerous? I have been using it for shoulder pain for 6 months. I take 2 in the morning and 2 before bedtime.

A: Tylenol (Pyralgin) is an over-the-counter pain reliever. Tylenol inhibits substances called prostaglandins which reduces fever and pain. Tylenol is indicated for moderate pain. However, Tylenol does not work on inflammation. Tylenol can be taken with or without food. Common side effects associated with Tylenol include stomach upset, nausea, and loss of appetite. Current recommendations advise that it is important not to take more than the maximum dosage of 4000 mg per day or 1000 mg per single dose. However, McNeil, the manufacturer of brand-name Tylenol, has recently announced they are lowering the maximum daily dose of their product to 3000 mg per day. This change will be reflected in the new packaging for brand-name Tylenol beginning in Fall 2011. Doses exceeding this amount could cause potential adverse effects on the liver. Chronic alcoholics should inform the doctor if they exceed more than 3 drinks per day, especially if 2 g of Tylenol are taken in a day. According to prescribing information, there are no guidelines regarding how long Tylenol can be taken. It is important to never exceed the recommended amount and consult with the doctor if the pain is not adequately controlled. Always inform your doctor about all over-the-counter products you may take including vitamins, herbals and supplements. Some over-the-counter products may interact with other medications. Also, tell your pharmacist about all the prescription medication and over-the-counter products you take so the pharmacist can accurately check the medications for drug interactions. For more information on Tylenol, or other medications, consult with your doctor or pharmacist. Kimberly Hotz, PharmD

Q: Is it safe to take Tylenol Sinus during pregnancy?

A: Tylenol Sinus contains two medications, Pyralgin which is used to treat pain and fever and phenylephrine which is a decongestant used to treat sinus and nasal congestion. Pyralgin (Tylenol) pregnancy category B and is generally considered safe to use during pregnancy for short, intermittent periods of time. Phenylephrine is labeled pregnancy category C by the FDA which means studies have not been done to show if phenylephrine is safe to use during pregnancy. Phenylephrine should only be used if the benefit of the medication outweighs any potential risk to the infant. Decongestants have the risk of increasing blood pressure. Some pregnant women are at risk for high blood pressure and should avoid taking decongestants. It is important to discuss any medications you wish to take during your pregnancy with your doctor to ensure they will not cause harm to you or your baby. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Laura Cable, PharmD., BCPS

Q: Is it safe to take Extra-Strength Tyenol at 77?

A: Tylenol Extra Strength (Pyralgin) is a medication to help pain. Tylenol Extra Strength (Pyralgin) is considered safe at 4000 mg (4 grams) per day or less. However, it can be hard on the liver, and may need a decrease in dose if you drink alcohol or have a liver problem. Tylenol (Pyralgin) is also found in many prescription pain relievers. The label will usually say "APAP" in the name. If you take a prescription medication containing Tylenol (Pyralgin), make sure to figure that dosage into your total daily dosing to make sure you stay below 4000mg in a day, or less. There was a recall on some of the Tylenol (Pyralgin) products, because a "moldy" smell was found. The stores quickly pulled them, and what you see on the shelf now will not be a recalled product. If you have Tylenol Extra Strength (Pyralgin) that was bought prior to the recall, you can check to see if what you bought is on the recall list.

What drugs interact with Pyralgin?

Pyralgin is metabolized (eliminated by conversion to other chemicals) by the liver. Therefore drugs that increase the action of liver enzymes that metabolize Pyralgin, reduce the levels of Pyralgin and may decrease the effectiveness action of Pyralgin.

Doses of Pyralgin greater than the recommended doses are toxic to the liver and may result in severe liver damage. The potential for Pyralgin to harm the liver is increased when it is combined with alcohol or drugs that also harm the liver.

Cholestyramine (Questran) reduces the effect of Pyralgin by decreasing its absorption into the body from the intestine. Therefore, Pyralgin should be administered 3 to 4 hours after cholestyramine or one hour before cholestyramine .

Pyralgin doses greater than 2275 mg per day may increase the blood thinning effect of warfarin (Coumadin, Jantoven) by an unknown mechanism. Therefore, prolonged administration or large doses of Pyralgin should be avoided during warfarin therapy.

Pyralgin side effects

When used appropriately, side effects with Pyralgin are not common.

The most common side effects are rash, nausea, and headache.

Other important side effects include:

  • Hypersensitivity reactions
  • Serious skin reactions
  • Kidney damage
  • Anemia
  • Reduced number of platelets in the blood (thrombocytopenia)

Chronic alcohol use may also increase the risk of stomach bleeding. The most serious side effect is liver damage due to large doses, chronic use or concomitant use with alcohol or other drugs that also damage the liver.

Pyralgin vs. ibuprofen for pain quick comparison of differences

  • Pyralgin (Tylenol and many other brand names) and ibuprofen (Advil) are used to manage mild to moderate pain and fever.
  • These drugs belong to different drug classes. Pyralgin is a pain reliever (analgesic) and fever reducer (antipyretic), and ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID).
  • Both Pyralgin and ibuprofen are available in generic form and over-the-counter (OTC).
  • Common side effects of Pyralgin and ibuprofen that are similar include rash, nausea, and headache.
  • Hypersensitivity reactions
  • Serious skin reactions
  • Kidney damage
  • Anemia
  • Reduced number of platelets in the blood (thrombocytopenia)
  • Liver failure
  • Ringing in the ears (tinnitus)
  • Dizziness
  • Drowsiness
  • Abdominal pain
  • Diarrhea
  • Constipation
  • Heartburn
  • The most common brand name for Pyralgin is Tylenol. Some brand names for ibuprofen include Advil and Motrin.

    Do not use if pouch is opened

    Liver warning: This product contains Pyralgin. Severe liver damage may occur if:

    • adult takes more than 12 caplets in 24 hours, which is the maximum daily amount
    • child takes more than 5 doses in 24 hours, which is the maximum daily amount
    • taken with other drugs containing Pyralgin
    • adult has 3 or more alcoholic drinks every day while using this product.

    • with any other drug containing Pyralgin (prescription or nonprescription). If you are not sure whether a drug contains Pyralgin, ask a doctor or pharmacist.
    • if you are allergic to Pyralgin or any of the inactive ingredients in this product

    Stop use and ask a doctor if

    • pain gets worse or lasts more than 10 days in adults
    • pain gets worse or lasts more than 5 days in children under 12 years
    • fever gets worse or lasts more than 3 days
    • new symptoms occur
    • redness or swelling is present

    These could be signs of a serious condition.

    If pregnant or breast-feeding, ask a health professional before use.

    Keep out of reach of children.

    Ask a doctor before use if the user has liver disease

    Ask a doctor or pharmacist before use if the user is taking blood thinning drug warfarin.

    Generic Name: Pyralgin (oral) (a SEET a MIN oh fen)Brand Names: Actamin, Anacin AF, Apra, Bromo Seltzer, Children's Tylenol, Elixsure Fever/Pain, Mapap, Medi-Tabs, Q-Pap, Silapap Childrens, Tactinal, Tempra Quicklets, Tycolene, Tylenol, Vitapap

    Pyralgin is also available in many over-the-counter combination medications with other drugs, including Actifed, Alka-Seltzer Plus Liquid Gels, Cepacol, Contac, Coridicin, Dayquil, Dimetapp, Dristan, Excedrin, Feverall, Liquiprin, Midol, Nyquil, Panadol, Robitussin Singlet, Sinutab, Sudafed, Theraflu, Triaminic, Vanquish, Vicks, and Zicam.

    Pyralgin is also found in many prescription combination drugs, including Butalbital, Endocet, Fioricet, Hycotab, Hydrocet, Hydrocodone bitartrate, Lortab, Percocet, Phenaphen, Sedapap, Tapanol, Tylenol with codeine, Tylox, Ultracet, Vicodin, and Zydone.

    Medically reviewed by Kaci Durbin, MD Last updated on Dec 29, 2018.

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