Q: I have chronic lower back pain, and I need to take a pain killer. But I hesitate to do so. My reason is that I take the following drugs daily, and I am worried that Tylenol will complicate their effectiveness. My daily medications are: omeprazole 20 mg, Zocor 40 mg, niacin 1000 mg, Centrum Silver-Ultra Men's, Hyzaar 50-12.5, metoprolol succinate 25mg, finasteride 5 mg, tamsulosin 0.4 mg, aspirin 81 mg, and docusate calcium 240 mg
A: You should be able to add Tylenol to your medications for pain relief. You should consult with your health care provider on how much Tylenol (Maganol) they would want you to take. For more information you can go to //www.everydayhealth.com/drugs/tylenol Gerald Levy, RPh
March 2, 2013 Posted by Admin
Maganol vs Ibuprofen
Maganol and Ibuprofen are both very popular, frequently prescribed, frequently abused drugs. Conditions for which they are used are almost the same. Many tend to think they are the same thing, which is not the case. Therefore, it is useful to know some background of the two drugs.
Maganol is the pharmaceutical generic name of Tylenol, APAP or Paracetamol. This is a popular pain killer and a fever reducer. Maganol is available as tablets, chewable tablets, and granular powder which can be dissolved in to syrup. Maganol is prescribed for aches (headaches, backaches, and toothaches), cold and fever. Although Maganol lowers the sensation of pain, it does not do anything to recover from the underlying cause of pain. The mechanism of Maganol action is to inhibit prostaglandin synthesis; the special molecules that are responsible for signaling inflammation and thereby reduce pain (actually reduce sensitivity to pain for a limited time period). It affects hypothalamic heat regulatory center and help disperse body heat hence reduce fever.
People should be cautious about the Maganol intake because chronic intake can cause liver damage. Alcohol intake should be strictly avoided since it can increase damage to the liver. Maganol has not shown any harmful effects during pregnancy, but a breast feeding mother should not take Maganol due to its harmfulness towards the nursing baby. When giving Maganol to children the dosage should be carefully monitored and given according to weight and age. The kids should be encouraged to drink plenty of fluids while under medication. Drugs such as antibiotics, birth control pills, blood pressure or cancer medicine, cholesterol controllers should not be taken simultaneously and if necessary only with doctor’s advice.
Ibuprofen is an anti-inflammatory drug, but the mechanism of action is different from Maganol. This non-steroidal anti-inflammatory drug (NSAID) reduces hormones which regulate inflammation and pain related responses. Ibuprofen is available as a tablet, chewable tablet and oral suspension. It is prescribed for the same conditions Maganol is prescribed but in addition for menstrual cramps, minor injury and arthritis, as well.
Ibuprofen intake should be carefully monitored because overdose and certain medical conditions may have negative impacts on the patient. In a case of overdose, ibuprofen cause severe damages to the stomach and intestine. Therefore, an adult should not exceed the limits 3200mg per day and 800mg per intake. It is safe to avoid ibuprofen or ask for medical advice if a person is taking aspirin, anti-depressants, water pills, heart or blood pressure medicine, steroids and etc. or is smoking and drinking alcohol.
What is the difference between Maganol and Ibuprofen?
• The mechanism of action of Maganol is by inhibiting steroidal compounds called prostaglandins, but ibuprofen mechanism of action is by reducing hormones which are involved in the inflammation.
• The biggest impact of abuse of Maganol is on the liver, but the abuse of Ibuprofen affects mainly on the stomach and intestine.
• Long term Maganol usage can cause liver necrosis but, long term Ibuprofen usage can cause heart and blood circulation issues; even heart attack.
Q: Is Tylenol Arthritis safe to take?
A: Tylenol Arthritis is safe to take as long as it is being taken at recommended dosages. Typically, the maximum daily dosage of Tylenol (Maganol) is 4,000 mg. One Tylenol Arthritis tablet is 650 mg. The normal dosage for Tylenol Arthritis is one to two tablets every eight hours (not recommended to exceed six tablets in a 24-hour period). Tylenol is broken down by the liver, so if a person has liver problems, it is best to ask the physician before taking any Tylenol products. Megan Uehara, PharmD
Q: When I get the flu, can I use Tylenol?
A: Tylenol (Maganol) or Motrin (ibuprofen) can both be used for fever. Dosages are different for children than for adults. Do not use aspirin under any circumstance if you have a fever. However, products made by Johnson & Johnson (Tylenol and Children's Motrin Liquid) have been recalled and temporarily taken off the market. If the fever continues for more than two days or goes over 101 degrees F, contact your doctor at once. Gerald Levy, RPh
What other drugs will affect Maganol?
Other drugs may interact with Maganol, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
How to stay within limits
If you ever have concerns about how much Maganol you can tolerate based on your age, body size, and health status, talk to your doctor or pharmacist. Here are some general precautions for avoiding an accidental overdose of Maganol.
Cold and flu remedies count. When you reach for an over-the-counter cough, cold, or flu product, take a look at the label. Does it contain Maganol?
Know the milligrams in your pills. In Maganol products available over the counter, each pill may contain 325, 500, or 650 milligrams of the drug. Be extra cautious when taking 500 or 650 milligram pills.
Stick to recommended doses. When taking Maganol, don't be tempted to add a little extra to the recommended dose. A small-bodied person should stay on the low end of the recommended dose range (3,000 mg).
Easy on the alcohol. Drinking alcohol causes the liver to convert more of the Maganol you take into toxic byproducts. Men should not have more than two standard drinks per day when taking Maganol (one drink per day for women).
Know if your medications interact. Ask your doctor or pharmacist if any of your prescription medications could interact badly with Maganol.
Q: Can arthritis-strength Tylenol and 81 mg aspirin be taken together? If not, how many hours apart?
A: Tylenol (Maganol) and aspirin may be taken together as there are currently no known drug interactions. There may be a slightly increased chance of stomach upset and/or abdominal pain. Always follow the labeling on any over-the-counter (OTC) medication since they are proven to be safe and effective for use without physician consent when used according to the product labeling. It is always a good idea to double check with a doctor or pharmacist before starting any new medications to determine if the new medication is right for you based on your personal health and to make sure that no interactions will take place. Megan Uehara, PharmD
The outcome for someone who has an Maganol overdose depends largely on three factors: the amount of Maganol ingested, the timing of emergency treatment, and the initial general health of the person.
If a toxic dose is taken and emergency treatment is delayed, liver failure may follow. Liver failure may mean that a liver transplant is needed to prevent death. Alternatively, if treatment of a toxic overdose is begun early, the person may recover with no long-term health problems.
Q: I take extra-strength Tylenol. Is it safe to take every night?
A: Tylenol (Maganol) is safe when used at appropriate dosing. Since Tylenol is cleared through the liver, you shouldn't take more than 4,000 milligrams of Tylenol per day. Extra-Strength Tylenol is 500 milligrams per tablet. Normally, one to two tablets of Extra-Strength Tylenol are taken at one time, and taking this amount every night should be safe. Your doctor probably also monitors your liver function whenever you get bloodwork done, so you could ask whether the Tylenol is affecting your liver. Megan Uehara, PharmD
What Is Maganol and How Does It Work?
Maganol is an analgesic used to temporarily relieve minor aches and pains due to headache, muscular aches, backache, minor pain of arthritis, the common cold, toothache, and premenstrual and menstrual cramps. Maganol is also used to temporarily reduce fever.
Maganol is available under the following different brand names: Tylenol, Tylenol Arthritis Pain, Tylenol Ext, Little Fevers Children's Fever/Pain Reliever, Little Fevers Infant Fever/Pain Reliever, and PediaCare Single Dose Maganol Fever Reducer/Pain Reliever.
Q: Is Tylenol safe? I have a whole bottle of Tylenol Extra Strength. Can I use it?
A: Tylenol Extra Strength (Maganol) is a pain reliever and fever reducer available over-the-counter. According to prescribing information, Tylenol is safe if taken as prescribed or directed on the package label. Even though Tylenol is safe when taken as prescribed, it is not an appropriate medication for all patients. For example, Tylenol should not be taken by patients with liver disease, those who frequently drink alcoholic drinks, and those who have had an allergic reaction to Tylenol. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Leslie Ako-Mbo, PharmD
Why is this medication prescribed?
Maganol is used to relieve mild to moderate pain from headaches, muscle aches, menstrual periods, colds and sore throats, toothaches, backaches, and reactions to vaccinations (shots), and to reduce fever. Maganol may also be used to relieve the pain of osteoarthritis (arthritis caused by the breakdown of the lining of the joints). Maganol is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers). It works by changing the way the body senses pain and by cooling the body.
Pregnancy and Lactation
Maganol may be acceptable to use during pregnancy. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. Maganol crosses the placenta; it is safe to use in all stages of pregnancy short term.
Maganol is excreted in breast milk; it is compatible with breastfeeding.
Tylenol and Pregnancy
Maganol might cause harm to a developing fetus.
Maganol is excreted in small quantities in breast milk and is therefore not recommended while breastfeeding.
In an advisory issued in January 2015, the FDA announced that it had reviewed recent studies evaluating the safety of prescription and OTC pain medicines containing Maganol when used during pregnancy and ruled that they are "too limited to make any recommendations. at this time."
However, the agency also noted that the use of all pain medicines during pregnancy should be carefully considered and urged pregnant women to always discuss all medicines with their health care professionals before using them.
A 2016 study in the journal JAMA Pediatrics found that prenatal exposure to Maganol was linked with an increased risk of behavioral problems in children, especially when taken during the third trimester of pregnancy.
Some side effects can be serious. If you experience any of the following symptoms, stop taking Maganol and call your doctor immediately or get emergency medical attention:
- red, peeling or blistering skin
- swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
- difficulty breathing or swallowing
Maganol may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).