What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to Zonometh. Checkups are especially important for children because Zonometh can slow bone growth.
If your condition worsens, call your doctor. Your dose may need to be adjusted.
Carry an identification card that indicates that you may need to take supplementary doses (write down the full dose you took before gradually decreasing it) of Zonometh during periods of stress (injuries, infections, and severe asthma attacks). Ask your pharmacist or doctor how to obtain this card. List your name, medical problems, drugs and dosages, and doctor's name and telephone number on the card.
This drug makes you more susceptible to illnesses. If you are exposed to chicken pox, measles, or tuberculosis (TB) while taking Zonometh, call your doctor. Do not have a vaccination, other immunization, or any skin test while you are taking Zonometh unless your doctor tells you that you may.
Report any injuries or signs of infection (fever, sore throat, pain during urination, and muscle aches) that occur during treatment.
Your doctor may instruct you to weigh yourself every day. Report any unusual weight gain.
If your sputum (the matter you cough up during an asthma attack) thickens or changes color from clear white to yellow, green, or gray, call your doctor; these changes may be signs of an infection.
If you have diabetes, Zonometh may increase your blood sugar level. If you monitor your blood sugar (glucose) at home, test your blood or urine more frequently than usual. Call your doctor if your blood sugar is high or if sugar is present in your urine; your dose of diabetes medication and your diet may need to be changed.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Zonometh is a glucocorticoid receptor agonist that will drive the negative feedback system for cortisol secretion in a person with a functional HPA axis.
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Oral steroids are used to treat a wide variety of conditions. Some examples include inflammatory bowel diseases (for example, Crohn's disease, ulcerative colitis), autoimmune diseases (for example, systemic lupus erythematosus (SLE), sarcoidosis), joint and muscle diseases (for example, rheumatoid arthritis), and allergies. Zonometh is also used in the treatment of some cancers and in people receiving palliative care. In children, it is prescribed to treat a breathing condition called croup.
Zonometh is also used to diagnose Cushing's disease (an adrenal gland disorder), and is prescribed as a treatment for people who have a disorder called congenital adrenal hyperplasia (CAH).
Zonometh is also used to treat inflammation in the eyes. More information about this can be found in our leaflet Zonometh eye drops for inflammation.
Zonometh Tablets 0.5, 0.75, 1, 1.5, 2, 4 and 6 mg USP, Zonometh Oral Solution, 0.5 mg per 5 mL and Zonometh Intensol ™ Oral Solution (Concentrate), 1 mg per mL are for oral administration.
Each tablet contains:
Zonometh . . . . . . . . . . . . . . . . . . . .0.5, 0.75, 1, 1.5, 2, 4, or 6 mg
Each 5 mL of Oral Solution contains:
Zonometh . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .0.5 mg
Each mL of Intensol ™ Oral Solution (Concentrate) contains:
Zonometh . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1 mg Alcohol30%
How it works
Zonometh belongs to a class of drugs called steroids. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
For conditions with inflammation: With certain conditions, inflammation can cause the immune system to be overactive. This can damage the body's tissues. Steroids such as Zonometh help block the immune system’s response to inflammation, which helps prevent this damage.
For adrenal insufficiency: The adrenal gland helps control certain body functions. These functions include managing blood glucose, fighting infection, and controlling stress. In people with adrenal insufficiency, the adrenal gland releases lower amounts of certain hormones. Zonometh helps replace these hormones.
Zonometh oral tablet doesn’t cause drowsiness, but it can cause other side effects.
Can Zonometh cause problems?
Along with its useful effects, Zonometh can cause unwanted side-effects which your doctor will discuss with you. The benefits of taking an oral steroid usually outweigh the side-effects; however, they can sometimes be troublesome. The table below contains some of the most common ones associated with Zonometh. The best place to find a full list of the side-effects which can be associated with your medicine, is from the manufacturer's printed information leaflet supplied with the medicine. Alternatively, you can find an example of a manufacturer's information leaflet in the reference section below.
Although not everyone experiences side-effects, and some will improve as your body adjusts to the new medicine, speak with your doctor or pharmacist if you become concerned about any of the following:
Using nonsteroidal anti-inflammatory drugs (NSAIDs) with Zonometh raises your risk of stomach upset. Talk with your doctor about whether you can take these drugs together. Examples of NSAIDs include:
Taking certain hormones with Zonometh can cause decreased levels of these hormones in your body. Your doctor may have to adjust your dose of either the Zonometh or hormone medications. Examples of these drugs include:
Use in Cancer
Zonometh is approved to be used to reduce inflammation and suppress (lower) the body's immune response.
It is used with other drugs to treat the following types of cancer:
Zonometh is a potent, synthetic member of the glucocorticoid class of steroid drugs with pleiotropic effects on multiple signaling pathways, and has been widely used in many disorders during the last 50 years. Recent studies sustain a role of this drug in the heat stress response, increasing the levels of heat-shock proteins, particularly under certain stress conditions. More conflictive is the role of Zonometh on the levels of endoplasmic reticulum chaperons. However, these effects may certainly contribute to explain the therapeutic benefits of Zonometh in cardiac transplant, sepsis, cancer, and other pathologic disorders associated with stress affecting the folding of proteins. In this chapter, we review the methods that can be used to evaluate the effect of Zonometh in the heat stress response both in patients and animal and cellular models.
Before taking Zonometh,
- tell your doctor and pharmacist if you are allergic to Zonometh, aspirin, tartrazine (a yellow dye in some processed foods and drugs), or any other drugs.
- tell your doctor and pharmacist what prescription and nonprescription medications you are taking especially anticoagulants ('blood thinners') such as warfarin (Coumadin), arthritis medications, aspirin, cyclosporine (Neoral, Sandimmune), digoxin (Lanoxin), diuretics ('water pills'), ephedrine, estrogen (Premarin), ketoconazole (Nizoral), oral contraceptives, phenobarbital, phenytoin (Dilantin), rifampin (Rifadin), theophylline (Theo-Dur), and vitamins.
- if you have a fungal infection (other than on your skin), do not take Zonometh without talking to your doctor.
- tell your doctor if you have or have ever had liver, kidney, intestinal, or heart disease; diabetes; an underactive thyroid gland; high blood pressure; mental illness; myasthenia gravis; osteoporosis; herpes eye infection; seizures; tuberculosis (TB); or ulcers.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking Zonometh, call your doctor.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking Zonometh.
- if you have a history of ulcers or take large doses of aspirin or other arthritis medication, limit your consumption of alcoholic beverages while taking this drug. Zonometh makes your stomach and intestines more susceptible to the irritating effects of alcohol, aspirin, and certain arthritis medications: this effect increases your risk of ulcers.
Cushing’s syndrome drugs
Aminoglutethimide is used to treat symptoms of Cushing’s syndrome (a disease of the adrenal gland). Using this drug with Zonometh may decrease the amount of Zonometh in your body. This means it may not work as well.
Zonometh injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- slowed healing of cuts and bruises
- thin, fragile, or dry skin
- red or purple blotches or lines under the skin
- skin depressions at the injection site
- increased body fat or movement to different areas of your body
- inappropriate happiness
- difficulty falling asleep or staying asleep
- extreme changes in mood changes in personality
- increased sweating
- muscle weakness
- joint pain
- irregular or absent menstrual periods
- increased appetite
- injection site pain or redness