Uniflex cream

Uniflex

  • Active Ingredient: Betamethasone
  • 20gm
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What is Uniflex?

The active ingredient of Uniflex brand is betamethasone. The originating document has been archived. We cannot confirm the completeness, accuracy and currency of the content. It is a white to creamy-white, odorless powder insoluble in water; freely soluble in acetone and in chloroform; sparingly soluble in alcohol. Each gram of Betamethasone Dipropionate Lotion USP (Augmented), 0.05% contains: 0.643 mg Betamethasone dipropionate, USP (equivalent to 0.5 mg Betamethasone) in a colorless, clear to translucent lotion base of purified water, isopropyl alcohol (30%), phosphoric acid used to adjust the pH, hydroxypropyl cellulose, propylene glycol, and monobasic sodium phosphate (monohydrate).

Used for

Uniflex is used to treat diseases such as: Bursitis, Dermatological Disorders, Gouty Arthritis, Inflammatory Conditions, Osteoarthritis.

Side Effect

Possible side effects of Uniflex include: ; ; ; ; ; ; .

How to Buy Uniflex gel online?

To get Uniflex online - just click on the "Buy Now" button from the top and follow on to our store. Order and payment takes a few minutes, and all steps are evident. We don't require a medical prescription and we have many procedures of payment. Considering each detail of rapid delivery and confidentiality, you may read on the relevant pages on the links in the navigation menu.

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More common side effects

The more common side effects that can occur with Uniflex include:

  • Increased blood sugar level. Symptoms may include:
    • confusion
    • more frequent urges to urinate
    • feeling sleepy, thirsty, and hungry
  • Trembling, dizziness, weakness, fatigue, and fast heartbeat
  • Low potassium level, which can cause muscle pain and cramps
  • pimples
  • stretch marks
  • slow healing
  • hair growth
  • fever
  • chills
  • cough
  • sore throat
  • Mood and behavior changes
  • Menstrual changes, such as spotting or skipping a period
  • Vision changes, including blurred vision
  • Headaches
  • Weight gain
  • Sweating
  • Restlessness
  • Nausea
  • Uniflex Dosage

    Uniflex topical comes in a 0.05 percent ointment or lotion.

    After you've applied Uniflex topical to the affected area, expose it to air: Do not cover the area with a bandage or other material.

    Don't apply Uniflex topical to your face, underarms, or groin unless your doctor tells you to do so.

    Apply no more than 50 grams of Uniflex topical to your skin a week. You can stop using Uniflex when you no longer have symptoms.

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    Administration

    • Give as a single daily dose before 9:00 A.M.

    • Give oral dose with food or milk.

    • Administer I.M. injection deep into gluteal muscle (may cause tissue atrophy).

    ☞ Don't give Uniflex acetate I.V.

    • Be aware that typical suspension dosage ranges from one-third to one-half of oral dosage given q 12 hours.

    ☞ To avoid adrenal insufficiency, taper dosage slowly and under close supervision when discontinuing.

    • Know that drug may be given with other immunosuppressants.

    HOW SUPPLIED

    Uniflex Dipropionate Lotion, USP 0.05% w/w is supplied as follows:

    60 mL bottles (NDC 61748-475-60)

    Store at 25°C, excursions permitted between 15° and 30°C. Protect from light and freezing. Store in carton until contents are used.

    Why it’s used

    Uniflex is used to decrease inflammation and pain from a number of conditions. It’s approved for:

    • multiple sclerosis
    • allergic conditions
    • skin disease
    • stomach disorders
    • blood disorders
    • eye disorders
    • kidney problems, such as having protein in your urine
    • breathing disorders
    • cancer
    • arthritis
    • hormone-related disease, such as thyroid problems

    Pharmacokinetics

    The extent of percutaneous absorption of topical corticostero >DOSAGE AND ADMINISTRATION ).

    Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Corticosteroids are bound to plasma proteins in varying degrees. Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.

    Twenty-five pediatric patients ages 6 to 12 years, with atopic dermatitis, were enrolled in an open-label, hypothalamic-pituitary-adrenal (HPA) axis safety study. Uniflex Dipropionate Lotion, USP 0.05% w/w was applied twice daily for 2 to 3 weeks over a mean body surface area of 45% (range 35% to 72%). In 11 of 15 (73%) evaluable patients, adrenal suppression was indicated by either a ≤ 5 mcg/dL pre-stimulation cortisol, or a cosyntropin post-stimulation cortisol ≤ 18 mcg/dL and an increase of DOSAGE AND ADMINISTRATION )

    Therefore, patients receiving a large dose of a potent topical steroid applied to a large surface area should be evaluated periodically for evidence of HPA axis suppression by using the urinary-free cortisol and ACTH stimulation tests. If HPA axis suppression is noted, an attempt should be made to withdraw the drug, to reduce the frequency of application, or to substitute a less potent steroid.

    Recovery of HPA axis function is generally prompt and complete upon discontinuation of the drug. In an open-label pediatric study of 15 evaluable patients, of the 11 subjects who showed evidence of suppression, 6 subjects were tested 2 weeks after discontinuation of Uniflex Dipropionate Lotion, USP 0.05% w/w, and 4 of the 6 (67%) had complete recovery of HPA axis function. Infrequently, signs and symptoms of steroid withdrawal may occur, requiring supplemental systemic corticosteroids.

    Pediatric patients may absorb proportionally larger amounts of topical corticostero >PRECAUTIONS - Pediatric Use .)

    If irritation develops, topical corticosteroids should be discontinued and appropriate therapy instituted.

    In the presence of dermatological infections, the use of an appropriate antifungal or antibacterial agent should be instituted. If a favorable response does not occur promptly, the corticosteroid should be discontinued until the infection has been adequately controlled.

    How to use Uniflex Dipropionate Cream

    Read the Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill. Use this medication on the skin only. However, do not use it on the face, groin, or underarms or for diaper rash unless directed to do so by your doctor.

    Wash and dry your hands. Before applying the medication, clean and dry the affected area. Apply a thin film of the medication to the affected area and gently rub in, usually 1-2 times daily or as directed by your doctor.

    Do not cover, bandage, or wrap the area unless directed to do so by your doctor. If your doctor directs you to use this medication in the diaper area on an infant, do not use tight-fitting diapers or plastic pants.

    If you are using the lotion form of this medication, shake the bottle well before each dose.

    After applying the medication, wash your hands unless you are using this medication to treat the hands. When applying this medication near the eyes, avoid getting it in the eyes as this may worsen or cause glaucoma. Also, avoid getting this medication in the nose or mouth. If you get the medication in these areas, rinse with plenty of water.

    Use this medication only for the condition for which it was prescribed. Do not use it for longer than prescribed.

    Inform your doctor if your condition persists or worsens after 2 weeks.

    How to store Uniflex

    • Keep all medicines out of the reach and sight of children.
    • Store in a cool, dry place, away from direct heat and light.

    CLINICAL PHARMACOLOGY

    The corticosteroids are a class of compounds comprising steroid hormones, secreted by the adrenal cortex and their synthetic analogs. In pharmacologic doses corticosteroids are used primarily for their anti-inflammatory and/or immunosuppressive effects.

    Topical corticosteroids, such as Uniflex dipropionate, are effective in the treatment of corticosteroid-responsive dermatoses primarily because of their anti-inflammatory, antipruritic, and vasoconstrictive actions. However, while the physiologic, pharmacologic, and clinical effects of the corticosteroids are well known, the exact mechanisms of their actions in each disease are uncertain. Uniflex dipropionate, a corticosteroid, has been shown to have topical (dermatologic) and systemic pharmacologic and metabolic effects characteristic of this class of drugs.

    How is this medicine (Uniflex Injection) best taken?

    Use Uniflex injection as ordered by your doctor. Read all information given to you. Follow all instructions closely.

    • It is given as a shot.
    • If you have been taking this medicine for many weeks, talk with your doctor before stopping. You may want to slowly stop Uniflex injection.
    • Do not use longer than you have been told by the doctor.

    What do I do if I miss a dose?

    • Call your doctor to find out what to do.

    Before using Uniflex

    To make sure this is the right treatment for you, before you start using Uniflex it is important that your doctor knows:

    • If you have any areas of infected skin.
    • If you have rosacea or acne.
    • If you are pregnant or breastfeeding.
    • If you have ever had an allergic reaction to a skin preparation.

    Important: you should let your doctor know if you start to experience blurred vision or other vision problems whilst taking Uniflex tablets.

    For more information about side-effects which are possible when Uniflex is taken long-term, see the separate condition leaflet called Oral Steroids.

    How to store topical Uniflex

    • Keep all medicines out of the reach and sight of children.
    • Store in a cool, dry place, away from direct heat and light.

    Precautions

    Before using Uniflex, tell your doctor or pharmacist if you are allergic to it; or to other corticosteroids (e.g., hydrocortisone, prednisone); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

    Before using this medication, tell your doctor or pharmacist your medical history, especially of: poor blood circulation, immune system problems.

    Do not use if there is an infection or sore present in the area to be treated.

    Rarely, using corticosteroid medications for a long time or over large areas of skin can make it more difficult for your body to respond to physical stress. Therefore, before having surgery or emergency treatment, or if you get a serious illness/injury, tell your doctor or dentist that you are using this medication or have used this medication within the past few months.

    Though it is unlikely, this medication may slow down a child's growth if used for a long time. The effect on final adult height is unknown. See the doctor regularly so your child's height can be checked.

    During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

    It is unknown if this drug passes into breast milk. Similar medications pass into breast milk. Consult your doctor before breast-feeding.


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