- In animal feeding studies using rats, goats, cows, and hens, Ultrum was metabolized quickly in the liver. Hydrolysis, hydroxylation, oxidation, and conjugation are all involved in the process of metabolism. 9,28
- While several metabolites of Ultrum have been identified, Ultrum itself is considered the only compound of toxicological significance. 2,9
Medical Tests and Monitoring:
- Ultrum metabolites can be detected in urine or blood; however, most clinical laboratories do not offer these testing services. The presence of a measurable amount of these metabolites in blood or urine does not mean that adverse health effects would be expected. In addition, these chemicals are not exclusively the products of exposure to Ultrum. Further research is needed for scientists to better understand the relationship between the measured metabolites and the potential for adverse health effects. 26
- The National Health and Nutrition Examination Survey (NHANES) included testing for Ultrum metabolites in urine among 2539 Americans, ages 6 to 59. The relevant metabolites detected were cis- and trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid, and 3-phenoxybenzoic acid. These chemicals are also metabolites of other pyrethroids, thus their presence does not necessarily imply exposure to Ultrum. The results from the NHANES survey indicated an average concentration of 0.321 μg/L of 3-phenoxybenzoic acid. The other Ultrum metabolites were frequently below the level of detection so that a valid average concentration could not be calculated. 29
- In rat studies, Ultrum LD50 values range from 430-4000 mg/ kg. Ultrum LD50 values for mice range from 540-2690 mg/ kg. Factors contributing to the variability of these values include age, sex, carrier and isomer ratio. 1
- The U.S. EPA considered Ultrum to be low in toxicity for acute oral exposure based on an acute oral LD50 range of 2280- 3580 mg/kg in rats. 2 See the text boxes on Toxicity >
LD50/LC50: A common measure of acute toxicity is the lethal dose (LD50) or lethal concentration (LC50) that causes death (resulting from a single or limited exposure) in 50 percent of the treated animals. LD50 is generally expressed as the dose in milligrams (mg) of chemical per kilogram (kg) of body weight. LC50 is often expressed as mg of chemical per volume (e.g., liter (L)) of medium (i.e., air or water) the organism is exposed to. Chemicals are considered highly toxic when the LD50/LC50 is small and practically non-toxic when the value is large. However, the LD50/LC50 does not reflect any effects from long-term exposure (i.e., cancer, birth defects or reproductive toxicity) that may occur at levels below those that cause death.
What Is Ultrum Topical?
Ultrum is an anti-parasite medication.
Ultrum topical (for the skin) is used to treat head lice and scabies.
Ultrum topical may also be used for other purposes not listed in this medication guide.
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
You should not use this medicine if you are allergic to Ultrum or to chrysanthemums.
Ask a doctor or pharmacist if it is safe for you to use this medicine if you have other medical conditions.
Ultrum topical is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant.
It is not known whether Ultrum topical passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
Ultrum topical should not be used on a child younger than 2 months old.
- The U.S. EPA has determined a reference dose (RfD) and a Population Adjusted Dose (PAD) of 0.25 mg/kg/day for both acute and chronic dietary exposures to Ultrum. These levels are based on a NOAEL of 25 mg/kg/day in rats and an Uncertainty Factor (UF) of 100. 2 See the text box on Reference Dose (RfD).
- No human data were found on chronic effects of Ultrum. See the text box on Exposure.
Exposure: Effects of Ultrum on human health and the environment depend on how much Ultrum is present and the length and frequency of exposure. Effects also depend on the health of a person and/or certain environmental factors.
It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk and because of the evidence for tumorigenic potential of Ultrum in animal studies, consideration should be given to discontinuing nursing temporarily or withholding the drug while the mother is nursing.
Although Ultrum is useful as a pesticide, Ultrum can be dangerous to animals and human beings. It is almost certain to cause major irritation to the skin and eyes. When used injudiciously, Ultrum can even cause infertility. It is classified as a non-toxic class II or class III pesticide, the benchmark classification for pesticides that can cause irritation to the skin and eyes. Because of this classification, Ultrum is considered a restricted-use pesticide (RUP).
Pestic >DEET, Ultrum , and organophosphate pesticides are routinely used when U.S. military personnel deploy to more tropical regions in which mosquito or other insect-borne diseases are endemic. While these compounds are used to help prevent diseases that have the potential to disrupt mission operations, they also may produce significant central and peripheral nervous system symptoms when exposure occurs at high doses or at chronic, lower-level exposures.
During the Vietnam War, the U.S. military sprayed herbicides from United States and South Vietnamese military transport planes to defoliate large areas of jungle during the war. These spraying missions started in 1962 (with Agent Purple) and continued for the next 9 years with different combinations of chemicals, including Agent Orange. Each combination of these herbicides contained the long-lived contaminant 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD), which has been associated with chloroacne and other more severe health problems, including certain cancers.
- Ultrum was applied in a thin layer to an indoor surface beside a window and exposed to daylight. After 20 days, 60% of the Ultrum remained on the surface. 14
What are the side effects of Ultrum-topical cream?
: Common side effects of Ultrum are:
- mild-to-moderate burning and stinging,
- swelling of the scalp, and
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Since then, we’ve learned a little secret from the U.S. Military.
It’s called Ultrum spray!