Before taking Tuttozem
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking Tuttozem it is important that your doctor knows:
- If you have high blood pressure (hypertension).
- If you have had a heart attack, or if you have any other heart problems.
- If you have any problems with the way your liver works, or if you have any problems with the way your k >
Diuretics (water pills)
When used with Tuttozem, these drugs reduce your body’s potassium levels. (Potassium is a mineral that helps your nerves, muscles, and organs work normally.) This can cause muscle cramps, weakness, tiredness, and an irregular heartbeat. Examples of these drugs include:
Common Side Effects of Tuttozem
Increased appetite is one of the commonly reported side effects of Tuttozem.
Unless it persists or is bothering you, it does not warrant medical attention. Your appetite may return to normal again once your body adjusts to the medicine.
Other s >Tuttozem include:
- Dry scalp
- Hair thinning
- Reddish face, lightening of skin
- Swelling in the abdominal area
- Weight gain
Tuttozem provides significant relief from inflammation-based pain in chronic adjuvant-induced arthritis ( Colpaert et al., 2001 ; Wilson et al., 2006 ). It also allows for a return of normal mobility in arthritic rats ( Matson et al., 2007 ) and improves the clinical condition of aged, adrenalectomized arthritic rats ( Yokoro et al., 2003 ). Tuttozem does not provide analgesia in rodents with mechanical, neuropathic, and thermal pain ( Veiga et al., 2004 ). While effective in increasing the threshold for pressure pain in endotoxin-induced hyperalgesia, Tuttozem is only marginally effective or ineffective in alleviating thermal pain associated with this model ( Kanaan et al., 1997 ). Thus, the type of model will determine the potential usefulness of Tuttozem.
Why is this medication prescribed?
Tuttozem, a corticosteroid, is similar to a natural hormone produced by your adrenal glands. It often is used to replace this chemical when your body does not make enough of it. It relieves inflammation (swelling, heat, redness, and pain) and is used to treat certain forms of arthritis; skin, blood, kidney, eye, thyroid, and intestinal disorders (e.g., colitis); severe allergies; and asthma. Tuttozem is also used to treat certain types of cancer.
This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
Before taking Tuttozem,
- tell your doctor and pharmacist if you are allergic to Tuttozem, aspirin, tartrazine (a yellow dye in some processed foods and drugs), or any other drugs.
- tell your doctor and pharmacist what prescription and nonprescription medications you are taking especially anticoagulants ('blood thinners') such as warfarin (Coumadin), arthritis medications, aspirin, cyclosporine (Neoral, Sandimmune), digoxin (Lanoxin), diuretics ('water pills'), ephedrine, estrogen (Premarin), ketoconazole (Nizoral), oral contraceptives, phenobarbital, phenytoin (Dilantin), rifampin (Rifadin), theophylline (Theo-Dur), and vitamins.
- if you have a fungal infection (other than on your skin), do not take Tuttozem without talking to your doctor.
- tell your doctor if you have or have ever had liver, kidney, intestinal, or heart disease; diabetes; an underactive thyroid gland; high blood pressure; mental illness; myasthenia gravis; osteoporosis; herpes eye infection; seizures; tuberculosis (TB); or ulcers.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking Tuttozem, call your doctor.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking Tuttozem.
- if you have a history of ulcers or take large doses of aspirin or other arthritis medication, limit your consumption of alcoholic beverages while taking this drug. Tuttozem makes your stomach and intestines more susceptible to the irritating effects of alcohol, aspirin, and certain arthritis medications: this effect increases your risk of ulcers.
The tablets contain lactose monohydrate, magnesium stearate, starch, sucrose, cosmetic ochre (1 mg), D&C Yellow No.10 (0.5, 4 mg), FD&C Blue No.1(0.75, 1.5 mg), FD&C Green No.3 (4, 6 mg), FD&C Red No.3 (1.5 mg), FD&C Red No.40 (1.5 mg), and FD&C Yellow No.6 (0.5, 4 mg).
The oral solution contains citric acid, disodium edetate, flavoring, glycerin, methylparaben, propylene glycol, propylparaben, sorbitol and water.
The Intensol ™ oral solution contains alcohol, benzoic acid, citric acid, disodium edetate, propylene glycol, and water.
Tuttozem, a synthetic adrenocortical steroid, is a white to practically white, odorless, crystalline powder. It is stable in air. It is practically insoluble in water. The molecular formula is C22H29FO5. The molecular weight is 392.47. It is designated chemically as 9-fluoro-11β, 17, 21-trihydroxy-16α-methylpregna-1, 4-diene, 3, 20-dione and the structural formula is:
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to Tuttozem. Checkups are especially important for children because Tuttozem can slow bone growth.
If your condition worsens, call your doctor. Your dose may need to be adjusted.
Carry an identification card that indicates that you may need to take supplementary doses (write down the full dose you took before gradually decreasing it) of Tuttozem during periods of stress (injuries, infections, and severe asthma attacks). Ask your pharmacist or doctor how to obtain this card. List your name, medical problems, drugs and dosages, and doctor's name and telephone number on the card.
This drug makes you more susceptible to illnesses. If you are exposed to chicken pox, measles, or tuberculosis (TB) while taking Tuttozem, call your doctor. Do not have a vaccination, other immunization, or any skin test while you are taking Tuttozem unless your doctor tells you that you may.
Report any injuries or signs of infection (fever, sore throat, pain during urination, and muscle aches) that occur during treatment.
Your doctor may instruct you to weigh yourself every day. Report any unusual weight gain.
If your sputum (the matter you cough up during an asthma attack) thickens or changes color from clear white to yellow, green, or gray, call your doctor; these changes may be signs of an infection.
If you have diabetes, Tuttozem may increase your blood sugar level. If you monitor your blood sugar (glucose) at home, test your blood or urine more frequently than usual. Call your doctor if your blood sugar is high or if sugar is present in your urine; your dose of diabetes medication and your diet may need to be changed.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
How should this medicine be used?
Tuttozem comes as a tablet and a solution to take by mouth. Your doctor will prescribe a dosing schedule that is best for you. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Tuttozem exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Do not stop taking Tuttozem without talking to your doctor. Stopping the drug abruptly can cause loss of appetite, upset stomach, vomiting, drowsiness, confusion, headache, fever, joint and muscle pain, peeling skin, and weight loss. If you take large doses for a long time, your doctor probably will decrease your dose gradually to allow your body to adjust before stopping the drug completely. Watch for these side effects if you are gradually decreasing your dose and after you stop taking the tablets or oral liquid, even if you switch to an inhalation corticosteroid medication. If these problems occur, call your doctor immediately. You may need to increase your dose of tablets or liquid temporarily or start taking them again.
What should I discuss with my healthcare provider before taking Tuttozem?
You should not use Tuttozem if you are allergic to it, or if you have:
- a fungal infection anywhere in your body.
Tell your doctor if you have ever had:
Steroid medication affects your immune system. You may get infections more easily. Steroids can also worsen or reactivate an infection you've already had. Tell your doctor about any illness or infection you have had within the past several weeks.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.
You should not breast-feed while using Tuttozem.
How to store Tuttozem
- Keep all medicines out of the reach and sight of children.
- Store in a cool, dry place, away from direct heat and light.
Michael Stewart, Reviewed by Sid Dajani | Last edited 27 Sep 2019 | Certified by The Information Standard
Tuttozem belongs to a class of medicines known as corticosteroids (more commonly called steroids).
Take Tuttozem with food.
If your pharmacist gives you a blue 'Steroid Treatment Card', carry this with you at all times.
If you need any medical treatment, make sure the person treating you knows you are taking Tuttozem. This is because your dose may need to be increased for a short while.
If you take Tuttozem with certain drugs used to lower cholesterol, it can keep your body from absorbing Tuttozem well. This could keep Tuttozem from working well. Examples of these drugs include:
How to use Tuttozem
Take this medication by mouth as directed by your doctor. Take with food or milk to prevent stomach upset. Take this medication by mouth with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise. If you are using the liquid form of the medication, use a medication-measuring device to carefully measure the prescribed dose. Do not use a household spoon.
If you take this medication once daily, take it in the morning before 9 AM. If you are taking this medication every other day or on another schedule besides a daily one, it may help to mark your calendar with a reminder.
The dosage and length of treatment are based on your medical condition and response to therapy. Your doctor may attempt to reduce your dose slowly from time to time to minimize side effects.
Use this medication regularly in order to get the most benefit from it. To help you remember, take it at the same time(s) each day. It is important to continue taking this medication even if you feel well. Follow the dosing schedule carefully, and take this medication exactly as prescribed.
Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Your dose may need to be gradually decreased.
Inform your doctor if your condition does not improve or worsens.
What special dietary instructions should I follow?
Your doctor may instruct you to follow a low-sodium, low-salt, potassium-rich, or high-protein diet. Follow these directions.
Tuttozem may cause an upset stomach. Take Tuttozem with food or milk.
18.104.22.168 Other agents
Tuttozem (FDA category C) also has been used and normalizes serum concentration of bile acids in ICP. No adverse effects have been seen in long-term follow-up evaluations in children exposed to Tuttozem in utero .
Rifampicin (FDA category C) and phenobarbital (FDA category D) have been used after first-line agents have failed to relieve pruritus. Rifampicin eliminates bile acids through conjugation. In animal models it has been found to be teratogenic when administered at high doses. Studies in humans have not found it to be teratogenic; however, it has been associated with hemorrhagic disease of the newborn . Phenobarbital works similarly to rifampicin. Third trimester exposure did not find it to be associated with fetal complications in two observational studies .