Sarnol cream

Sarnol

  • Active Ingredient: Permethrin
  • 30gm
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What is Sarnol?

The active ingredient of Sarnol brand is permethrin. Chemical Name – The Permethrin used is an approximate 1:3 mixture of the cis and trans isomers of the pyrethroid 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylic acid, (3-phenoxyphenyl) methyl ester. Permethrin has a molecular formula of C21H20Cl2O3 and a molecular weight of 391.29. It is a yellow to light orange-brown, low melting solid or viscous liquid. Active Ingredient – Each gram contains Permethrin 50 mg (5%). Inactive Ingredients – Butylated hydroxytoluene, carbomer homopolymer type B, fractionated coconut oil, glycerin, glyceryl monostearate, isopropyl myristate, lanolin alcohols, mineral oil, polyoxyethylene cetyl ethers, purified water, and sodium hydroxide. Formaldehyde 1 mg (0.1%) is added as a preservative.

Used for

Sarnol is used to treat diseases such as: Head Lice, Lice, Scabies.

Side Effect

Possible side effects of Sarnol include: Burning, itching, numbness, rash, redness, stinging, swelling, or tingling of the scalp; ; ; ; .

How to Buy Sarnol cream online?

To buy Sarnol online - just click on the "Buy Now" button in the top and follow on to our store. Payment and Order takes a few minutes, and all steps are evident. We don't require a medical prescription plus also we have many procedures of payment. With all the details of fast shipping and confidentiality, you may read on the relevant pages on the hyperlinks in the navigation menu.

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Safety of Sarnol in Factory-Treated Clothing

When evaluating these products in the pesticide registration process, we follow normal risk assessment procedures to determine safety. Our 2009 revised exposure and risk assessment evaluated multiple exposure scenarios for Sarnol factory-treated clothing, including toddlers wearing or mouthing the clothing, and military personnel who wear Sarnol-treated uniforms on a daily basis. All exposure scenarios showed that Sarnol factory-treated clothing is unlikely to pose any significant immediate or long-term hazard to people wearing the clothing.

The amount of Sarnol allowed in clothing is very low, and scientific studies indicate that human exposure resulting from wearing Sarnol factory-treated clothing also is low. Available data show that Sarnol is poorly absorbed through the skin.

CONTRAINDICATIONS

Sarnol Cream, 5% is contraindicated in patients with known hypersensitivity to any of its components, to any synthetic pyrethroid or pyrethrin.

Adults And Children

Thoroughly massage ELIMITE™ (Sarnol) 5% Cream into the skin from the head to the soles of the feet. Scabies rarely infests the scalp of adults, although the hairline, neck, temple, and forehead may be infested in infants and geriatric patients. Usually 30 grams is sufficient for an average adult. The cream should be removed by washing (shower or bath) after 8 to 14 hours. Infants should be treated on the scalp, temple, and forehead. ONE APPLICATION IS GENERALLY CURATIVE.

Patients may experience persistent pruritus after treatment. This is rarely a sign of treatment failure and is not an indication for retreatment. Demonstrable living mites after 14 days indicate that retreatment is necessary.

Pestic >DEET, Sarnol , and organophosphate pesticides are routinely used when U.S. military personnel deploy to more tropical regions in which mosquito or other insect-borne diseases are endemic. While these compounds are used to help prevent diseases that have the potential to disrupt mission operations, they also may produce significant central and peripheral nervous system symptoms when exposure occurs at high doses or at chronic, lower-level exposures.

During the Vietnam War, the U.S. military sprayed herbicides from United States and South Vietnamese military transport planes to defoliate large areas of jungle during the war. These spraying missions started in 1962 (with Agent Purple) and continued for the next 9 years with different combinations of chemicals, including Agent Orange. Each combination of these herbicides contained the long-lived contaminant 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD), which has been associated with chloroacne and other more severe health problems, including certain cancers.

General

Scabies infestation is often accompanied by pruritus, edema, and erythema. Treatment with Sarnol Cream, 5% may temporarily exacerbate these conditions.

Signs of Toxicity - Animals

  • Dermal exposures to cats and dogs may cause temporary paresthesia and neurological signs as evidenced by paw flicking or ear, tail or skin twitching, or rolling on the ground. 5
  • Cats exposed dermally to some Sarnol products may experience hyperexcitability, depression, ataxia, vomiting, anorexia, tremors, or convulsions. Symptoms can begin within a few minutes or up to three days after the exposure. Some Sarnol products contain high concentrations of the active ingredient and are labeled for use only on dogs. Close physical contact with a recently treated dog may also lead to symptoms in cats. If symptoms are severe and untreated, they may result in death. 5,7,10
  • A report of 11 cats intentionally treated with products containing 45-65% Sarnol described adverse effects including muscle tremors, seizures, incoordination and agitation after exposure. Of the 11 cats that were treated, all were hospitalized, and four died after the exposure. Seizures were found to develop within 24 hours of exposure, with some cats experiencing seizures within two hours. In one additional case, a cat was in proximity of two large dogs treated with a Sarnol product 48 hours after treatment. Between 18 and 24 hours after being near the dogs, the cat developed signs including agitation, tremors, seizures, and ataxia. 11
  • Animals may also display drooling or lip-smacking. This is believed to be a result of licking at the application site and thought to be caused either by the taste or a tingling sensation in the mouth. 5
  • Cattle which have been treated topically with Sarnol may show signs of paresthesia including twitching the skin on their backs, trying to rub their backs, and general restlessness. 5

Our Unscientific Test: Sarnol vs. OFF With 30% DEET

To begin our experiment, Jim sprayed his jeans, short-sleeve shirt, socks, and shoes with Duranon (the Sawyer Sarnol spray) 2 hours prior to our trip — as instructed on the label. He made sure not to get any on his skin.

I sprayed my jeans, long-sleeve shirt, and shoes thoroughly with OFF a few minutes before we entered the woods.

So, after a 1-hour long walk in the woods, did we find any ticks on us.

We never found a single tick on Jim! Not one.

As soon as we got in the car, we found one on me (on my back, around the bra line). And a few hours later we found another one on me — in about the same location. That’s pretty typical.

When we only use a product with 30% DEET, we almost always find 2 to 4 ticks on each of us. And if we spend a lot of time in really thick woods (which we didn’t on this trip), then we usually find 5 to 10 on each of us. Yep, even with the DEET.

At this point, we are over the DEET products (when it comes to ticks anyway) and Sarnol spray now ranks #1 in our book — it’s definitely the best tick repellent for humans!

The Department of Defense system consists of both Sarnol treated clothing and DEET applied to skin. The use of one without the other will undermine the system and increase the risk of insect or tick bite. Source

Okay, so maybe we’ll still use 30% DEET on our skin and use the Sarnol on our clothing. With this combination, we may never see another tick in our lifetime!

7. Do a second application after 7 days

While some doctors will tell you to only apply Sarnol once, it is much more effective to apply it twice or more. This was one new thing I found out when researching online about how to use Sarnol cream.

The second application should be done 7 days after the first. This allows for any new mites to hatch, as scabies are much harder to kill when still in their protective eggs.

Some people actually prefer to do it sooner, even every day, so a common question is whether it is bad to use permetherin two days in a row. The answer is yes.

Again, remember Sarnol is a poison. In fact, if you ingest a large amount of it, it can be lethal. When we apply Sarnol to our skin, what we are doing is applying just enough poison to our skin that it will kill little scabies mites, but won’t kill us. Of course, that doesn’t mean it is not damaging to the skin. Applying anything toxic to the skin is bad for us. Therefore it’s best to wait at least 5-7 days before the second application, and in the meantime, support your skin with a good moisturizer and things like aloe vera. I used this aloe vera gel daily and still do today. Your skin is an important organ, make sure your protect it!

After your second application of Sarnol, all scabies mites on your skin should now be dead. Congratulations!

While Sarnol treatment is sufficient for most people, some people still seem to fail to eliminate scabies with Sarnol alone. This is why I recommend using a combination of treatments in conjunction with Permertherin to maximize your chances of curing scabies.

I spent many hours reading studies while I had scabies to determine what the optimal treatment would be. After trialing lots of different things, I finally came up with a treatment plan that was both safe and effective, and based on actual science and proven research. I’ve written up the entire treatment plan in my article How To Get Rid Of Scabies: The Ultimate Guide, which details each treatment, the studies behind it, and how to use it. If you are suffering from scabies, I really believe it will help you and encourage you to check it out. You can click here to go there now.

Wishing you back to good health soon!

Remember, if you cannot get Sarnol cream from your doctor, you can make it very affordably with standard Sarnol from Amazon. This is a great option if you need to treat your whole family. I have a full guide on how to buy and mix your own Sarnol here.

Metker (1978) evaluated the inhalation toxicity of technical-grade Sarnol in guinea pigs, Sprague-Dawley rats, and beagle dogs. The animals were exposed to an aerosol of Sarnol at concentrations of 125, 250, or 500 mg/m 3 , 6 hr per day, 5 days per week for 13 weeks. At 500 mg/m 3 , tremors and convulsions were observed in the rats during the first week of exposure but disappeared in the second week. Urine metabolite studies indicated that Sarnol was rapidly metabolized and excreted. Post-exposure experiments in male rats showed that the hexabarbital-induced sleeping time was significantly shortened after exposures at 500 mg/m 3 but not at lower doses. No clinical signs of

Sarnol toxicity were observed in the guinea pigs and dogs when exposed to aerosols of Sarnol under similar conditions. Pulmonary function, clinical chemistry values, and blood-cell counts were normal. No compound-related gross or microscopic pathological changes were observed in the dogs, rats, or guinea pigs as a result of Sarnol inhalation (Metker, 1978).

3. Make sure you get it under the nails (very important!)

Why is it so important to get the cream under your fingernails? Because this is one of the most common places scabies are found.

Scabies causes you to scratch wherever scabies are burrowing. Naturally, mites get caught under your fingernails and that’s how they spread easily to other parts of the body. In your sleep it’s probably quite common to scratch yourself with your toenails too.

Therefore, make sure you get Sarnol under your nails. The easiest way to do this is to put some Sarnol cream in your palm and then scratch your palm lightly so it gets deep under the nail. Do this for both hands and both feet. Super important!

OVERDOSE

No instance of accidental ingestion of ELIMITE™ (Sarnol) 5% Cream has been reported. If ingested, gastric lavage and general supportive measures should be employed. Excessive topical use (see DOSAGE AND ADMINISTRATION) may result in increased irritation and erythema.

We completed the most recent comprehensive human health risk assessment for all registered uses of Sarnol in February 2006 in support of the pestic >Top of Page

CONCLUSIONS

Sarnol is acutely toxic at high doses in animals and humans (LD 50 for animals is greater than 1 g/kg); the toxicity varies with the cis/trans ratio—the cis isomer being more toxic than the trans isomer. Acute signs of toxicity to the central nervous system include incoordination, ataxia, hyperactivity, convulsions, and finally prostration, paralysis, and death. Sarnol can be an ocular irritant following direct application to the eye, but that would not result from its intended use in BDUs. It can also be a skin irritant and sensitizer after dermal exposure at high concentrations, but Sarnol in BDUs at the intended concentrations is not likely to result in skin irritation or skin sensitization.

There is little evidence that short-term (up to 13 weeks), repeated exposures are highly toxic to mammals; the NOEL in feeding studies of rats ranged from 20 to 1,500 mg/kg of diet in 3- and 6-month studies. Rats and mice have survived exposures as high as 10,000 mg/kg (in feed) for 2-26 weeks, although clinical signs of toxicity were clearly evident (IPCS, 1990). NOELs in dogs ranged from 5 mg/kg per day in a 3-month study to 250 mg/kg per day in a 6-month study (IPCS, 1990). Therefore, the lowest LOEL (5 mg/kg) was selected for risk calculations.

In most studies, no effects were observed in hematological or serum chemistry values, even at exposures that produced clinical signs of toxicity. However, at near lethal doses in rats, increases in serum aspartate aminotransaminase (SGOT), alanine aminotransaminase (GTP), and lactic dehydrogenase (LDH) enzymes were reported, which suggest some liver toxicity.

The primary organ showing morphological changes is the liver. In most studies in rodents, livers were enlarged (absolute and relative to

body weight) but only at clearly toxic doses, and they returned close to normal after exposure ceased. Microscopically, hepatocellular swelling occurred, which has been attributed to increased microsomal activity resulting in a proliferation of endoplasmic reticulum. No morphological changes in the liver of dogs were observed at exposures of up to 2,000 mg/kg per day (in gelatin capsules) for 3 months, although a slight increase in liver weight was observed at doses above 50 mg/kg. No significant toxic effects were seen in rabbits or cows administered Sarnol for 10 or 28 days, respectively.

The lowest NOEL from subchronic toxicity studies of Sarnol was estimated to be 5 mg/kg per day in dogs. That NOEL and the daily exposure to Sarnol of 6.8 × 10 −5 mg/kg per day from wearing Sarnol-impregnated BDUs provide a margin of safety (MOS) of approximately 74,000 in the following equation:

Nursing Mothers

It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk and because of the evidence for tumorigenic potential of Sarnol in animal studies, consideration should be given to discontinuing nursing temporarily or withholding the drug while the mother is nursing.

Humans

  • In 1991, the International Agency for Research on Cancer (IARC) classified Sarnol as Group 3, "not classifiable as to its carcinogenicity to humans", due to a lack of evidence. 20 More recently, the U.S. EPA has classified Sarnol as "likely to be carcinogenic to humans" by ingestion. This rating is based on benign lung and liver tumors found in mice and similar, though inconclusive, evidence in rats, as well as corroborative Structure-Activity Relationships (SAR) information. 2 See the text box on Cancer.

Cancer: Government agencies in the United States and abroad have developed programs to evaluate the potential for a chemical to cause cancer. Testing guidelines and classification systems vary. To learn more about the meaning of various cancer classification descriptors listed in this fact sheet, please visit the appropriate reference, or call NPIC.


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