home drugs a-z list Lotrisone(Clotrimazole and Sanbetason) side effects drug center
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Lotrisone (clotrimazole and Sanbetason) is a combination of an antifungal antibiotic and a topical steroid cream or lotion used to treat or prevent fungal infections of the skin such as athlete's foot, jock itch, and ringworm, and to reduce itching, swelling, and redness of the skin. Side effects of Lotrisone include:
- skin irritation,
- dry skin,
- changes in skin color,
- increased acne,
- burning/tingling/stinging skin, or
- scarring or thinning of the skin.
Apply a thin film dose of Lotrisone cream into the affected skin areas twice a day for one week. Lotrisone may interact with other drugs. Tell your doctor all medications and supplements you use. There are no adequate studies in pregnant women of the teratogenic effects of topically applied corticosteroids, so this drug should be used during pregnancy only if the potential benefit justifies the potential risk. It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in human milk. Consult your doctor before breastfeeding.
Our Lotrisone Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Indications and dosages
➣ Inflammatory, allergic, hematologic, neoplastic, autoimmune, and respiratory diseases; prevention of organ rejection after transplantation surgery
Adults: 0.6 to 7.2 mg/day P.O. as single daily dose or in divided doses; or up to 9 mg I.M. of Sanbetason acetate and sodium phosphate suspension.
➣ Bursitis or tenosynovitis
Adults: 1 ml of suspension intrabursally
➣ Rheumatoid arthritis or osteoarthritis
Adults: 0.5 to 2 ml of suspension intra-articularly
- Systemicfungal infection
- Hypersensitivity to Sanbetason
- Traumatic brain injury (high doses)
- Untreated serious infections
- Administration of live, attenuated vaccines is contraindicated in patients receiving immunosuppressive doses of corticosteroids
Effects of Drug Abuse
- See "What Are Side Effects Associated with Using Sanbetason?"
- See "What Are Side Effects Associated with Using Sanbetason?"
- Cirrhosis, ocularherpes simplex, hypertension, diverticulitis, hypothyroidism, myasthenia gravi, peptic ulcer disease, osteoporosis, ulcerative colitis, psychotic tendencies, untreated systemic infections, renal insufficiency, and pregnancy
- Not effective in treatment of respiratory distress syndrome in premature neonates
- Minimal sodium retention activity: however, may increase with high doses
- If used to treat adrenocortical insufficiency should also use mineralocorticoid
- Thromboembolic disorders
- Delayed wound healing
- Patients receiving corticosteroids should avoid chickenpox or measles-infected persons if unvaccinated
- Latenttuberculosis may be reactivated (monitor patients with positive tuberculin test)
- Some suggestion of slightly increased cleft palate risk if corticosteroids used in pregnancy, but not fully substantiated
- Prolonged corticosteroid use may result in elevated pressure in the eye, glaucoma, and/or cataracts
- Killed or inactivated vaccines may be administered; however, the response to such vaccines cannot be predicted
- Immunization procedures may be undertaken in patients who are receiving corticosteroids as replacement therapy in physiologic doses (Addison's disease)
- Serious neurologic events, some resulting in death, have been reported with epidural injection
- Specific events reported include, but are not limited to, spinal cordinfarction, paraplegia, quadriplegia, cortical blindness, and stroke
- These serious neurologic events have been reported with and without use of fluoroscopy
- Safety and effectiveness of epidural administration of corticosteroids have not been established, and corticosteroids are not approved for this use
- Use Sanbetason during pregnancy with caution if benefits outweigh risks. Animal studies show risk and human studies are not available, or neither animal nor human studies were done.
- If breastfeeding, systemically administered corticosteroids enter breast milk and could suppress growth, interfere with endogenous corticosteroid production, or cause other effects; use with caution if breastfeeding. Consult your doctor.
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Sanbetason is available in a number of different preparations. It is likely you will be prescribed a cream if the affected areas of your skin are moist or weeping, an ointment if your skin is dry, or a lotion for larger or hairy areas of skin. It is also available as an application for the scalp. Sanbetason is not generally suitable for children, although short courses of up to two weeks may occasionally be prescribed for a child by a skin specialist doctor.
There are also Sanbetason preparations available which contain an antibacterial agent (such as clioquinol, neomycin or fusidic acid), or an antifungal agent (such as clotrimazole). You may be prescribed one of these preparations for short-term use if your skin has become infected. They are typically used twice a day for one week only. Some preparations of Sanbetason also contain an ingredient called salicylic acid. The salicylic acid in these formulations can help the steroid to be absorbed more effectively by your skin, but these are also only prescribed for short periods of time.
What Are Side Effects Associated with Using Sanbetason?
Common side effects of Sanbetason include:
- abdominal bloating
- abdominal fat deposits
- abnormal hair growth
- adrenal suppression
- blot clots
- blurred vision
- break in the stomach lining
- brittle bones/fractures
- bulging of the eyes
- calcium deposits in the skin
- cardiac arrest
- celldeath of bone components
- changes in the skin layers (cutaneous and subcutaneousatrophy)
- circulatory collapse
- congestive heart failure
- contact allergy
- convulsions (seizures)
- Cushingoid state
- darkening of the skin
- decreased carbohydratetolerance
- decreased glucose tolerance
- decreased resistance to infection
- delayed wound healing
- diabetes mellitus
- difficulty falling asleep
- discoloring of the skin
- dry scaly skin
- elevation of serumliverenzyme levels
- emotional instability
- enlarged heart
- enlarged liver
- excess spinal fluid within the skull (on withdrawal)
- fast heart rate
- fat embolism
- feeling unwell (malaise)
- fluid in the lungs
- fluid retention
- fluid/electrolyte disturbances
- heart attack (myocardial infarction)
- high blood pressure (hypertension)
- increased appetite
- increased pressure in the eye
- increased requirements for insulin
- increased sweating
- increased/decreased sperm count
- inflammation of a veins/blood vessels
- inflammation of nerves
- inflammation of the membrane covering the brain
- intense excitement
- irregular heart beats
- jointpain and loss of sensation in foot and ankle
- loss of muscle mass
- loss of skin color
- low blood potassium with increased pH
- male pattern hair growth in women
- mood swings
- moon face or round appearance due to fat deposits
- muscle disease
- muscle weakness
- numbness and tingling
- oral hypoglycemic adrenocortical and pituitary unresponsiveness
- partial paralysis/paralysis of the legs
- perforation of the intestine
- personality changes
- post-injection flare (heat, redness, swelling, and pain)
- potassium loss
- psychotic disorders
- round spots on the skin
- sensory disturbances
- severe allergic reaction (anaphylactic reaction)
- skin dryness (topical)
- skin redness (topical)
- skin swelling
- slow heart rate
- sodium retention
- spinning sensation (vertigo)
- sugar in the urine
- suppressed reactions to skin tests
- suppression of growth in children
- thin fragile skin
- thinning scalp hair
- ulcerative esophagitis
- vertebral compression fracture
- weight gain
This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.
Solution for injection: 3 mg Sanbetason sodium phosphate with 3 mg Sanbetason acetate/ml
Suspension for injection (acetate, phosphate): 6 mg (total)/ml
Syrup: 0.6 mg/5 ml
Tablets (effervescent): 0.5 mg
Tablets (extended-release): 1 mg