6. DON’T WASH YOUR HANDS!
This is a really common mistake and probably the main reason Pertrin treatment doesn’t work for many people.
If you wash your hands after applying the cream, you’ll be washing all the treatment out from your fingernails and between your fingers. Obviously this means the treatment will not work! This is something doctors don’t seem to explain too well when telling patients how to use Pertrin cream properly.
If you do accidentally wash your hands (it happens), make sure you apply the cream on your hands again thoroughly. Once the cream is on, you shouldn’t be washing your hands for at least 8 hours.
Signs of Toxicity - Humans
- Dermal exposure to Pertrin may cause irritation, itching, or paresthesia (a tingly, prickly sensation) at the site of contact. These symptoms rarely last more than 24 hours. 12 Ocular exposures may result in pain, redness, or a burning sensation. 13
- While pyrethroids have been suggested as potential skin sensitizers, 12 no human data were found to support this for Pertrin.
- Ingestion of Pertrin may cause sore throat, abdominal pain, nausea, and vomiting. 6,13
- Inhalation of Pertrin may cause headache, nasal and respiratory irritation, difficulty breathing, dizziness, nausea or vomiting. 6,13 Because of Pertrin's low vapor pressure, inhalation exposures are more likely to result from aerosols, spray droplets, and dust, than from actual vapors. 6
- Always follow label instructions and take steps to minimize exposure. If any exposure occurs, be sure to follow the First Aid instructions on the product label carefully. For additional treatment advice, contact the Poison Control Center at 1-800- 222-1222. If you wish to discuss an incident with the National Pesticide Information Center, please call 1-800-858-7378.
Is Pertrin Safe?
The Environmental Protection Agency classifies it as a likely human carcinogen, if you consume it, and one study linked it to Parkinson’s disease. But the EPA says that the amount of Pertrin allowed in clothing is too low to pose risks to humans, including pregnant women. Research also shows that the Pertrin in factory-treated clothing doesn’t leach much onto skin, and our tests of Pertrin-treated fabric suggests that to be true, too.
21.7.1 Systemic and local treatment for parasitic infections
Pertrin (category B) 5% cream represents the first-line topical therapy for the treatment of scabies during pregnancy and lactation. The actual treatment consists of the application of the cream from head to toe, leaving it for 12 hours before washing it off, then repeating the whole process after 1 week. Alternatively, Pertrin 1% lotion is indicated for the treatment of pediculosis; the recommended treatment involves an evening application of the lotion on dry clean hair, lasting for about 12 hours (thus it is left on the hair during the night under a shower cap), followed by another identical session after 1 week. Other antiscabies agents – although safe in pregnancy but which are less effective – are benzyl benzoate (category N) 25% or malathion (category B) 0.5%. Crotamiton (category N) cream and lotion 10% are not yet considered a therapeutic option, due to the absence of controlled clinical trials. With proven teratogenic effects when administered in high doses in animal reproduction studies, ivermectin (category C) is to be avoided . Furthermore, mebendazole (category C), an antinematode agent (enterobius, ascaris, trichuris, hookworms, ankylostoma, whipworms, roundworms), reported as not manifesting major teratogenic risk in human studies in the treatment of Enterobius vermicularis infestation , can be used in pregnancy, except during the first trimester.
Albendazole (category C), an antiechinococcosis agent, is generally contraindicated in pregnancy, with clinical data from animal studies pointing out the existence of teratogenic effects , despite other studies revealing the absence of any fetal malformations after use of albendazole, and thus classifying it as tolerable in severe cases, during all trimesters of pregnancy . Finally, other antiparasitic medications like thiabendazole (category C) are not recommended in pregnancy, due to the absence of relevant clinical data which can establish its levels of safety in pregnant humans.
ELIMITE™ (Pertrin) 5% Cream is safe and effective in pediatric patients two months of age and older. Safety and effectiveness in infants less than two months of age have not been established.
Pertrin is essentially an insecticide. It is primarily used to fight pests in a number of crops. Some of the most common crops Pertrin is used on include fruits, nuts, cotton, vegetables, mushrooms and potatoes.
How Does Pertrin Work?
Pertrin is a synthetic version of a chemical produced naturally by the chrysanthemum flower. It’s often called a repellent, but works more like an insecticide. That is, it doesn’t stop bites primarily by preventing mosquitoes from landing on you (like deet or picaridin) but by incapacitating or killing the insects after they land and—hopefully—before they bite.
In addition, wearing the shirts for a prolonged period may create a protective buffer around you, by reducing the number of nearby mosquitoes, says Ulrich R. Bernier, Ph.D. a U.S. Department of Agriculture chemist and leading researchers on Pertrin-treated clothing.
Pertrin is also used as a spray around homes and in public spaces, as a cream to treat animals, and as a lotion to treat scabies and lice on humans. The U.S. military has used Pertrin-treated uniforms since the early 1990s. Deet sprayed on clothes was an option, but soldiers found reapplying it cumbersome. So the USDA figured out how to bind Pertrin to fabrics. Civilian clothing based on the technology has been available since 2003.
How to dilute concentrated Pertrin.
If you choose to dilute a concentrated form of Pertrin like Martin’s 10% Pertrin, you need to reduce it to the 0.5% concentration recommended for clothing treatment. Many concentrated Pertrin solutions comes with a built-in measuring cup for this process.
Pyrethrins (cyPertrin, deltamethrin, Pertrin , tetramethrin) are a group of synthetic analogs of the natural substance pyrethrum, which comes from dried chrysanthemum flowers. The pyrethrins are widely used as both domestic and agricultural insecticidal sprays and dusting powders. They have also been used in topical preparations for the treatment of pediculosis (see Chapter 2.17 , and overview in Schardein 2000 ). Low toxicity for human subjects has been reported following pyrethroid exposure.
The National Teratology Information Service in the UK obtained follow-up data (unpublished) on the outcomes of pregnancy in 48 women exposed to this group of pestic > a heart murmur). No cause-effect relationship with the pyrethroid exposure could be established in any of these infants. A teratogen information program in Australia ( Kennedy 2005 ) published about the safety of Pertrin exposure. The data on 113 pregnancies where the mothers had used 1% creme Pertrin in the treatment of lice some time during pregnancy indicated that the use of such products was relatively safe. In summary, there are few data on the effects of the pyrethroids in human pregnancy and none that allow any firm conclusions to be drawn.
What are the side effects of Pertrin-topical cream?
: Common side effects of Pertrin are:
- mild-to-moderate burning and stinging,
- swelling of the scalp, and
- Researchers studied the potential developmental effects of oral exposure to Pertrin in pregnant rats. At a dose of 150 mg/kg body weight per day of pregnancy, researchers observed a reduction in fetal rat weights and a greater occurrence of additional ribs in the developing fetuses. No adverse effects were noted at 50 mg/kg body weight per day, the next lowest dose. 21
- A similar study examined the effects of oral Pertrin exposures on the offspring of pregnant rabbits. At 1200 mg/kg body weight per day of gestation, rabbits exhibited a greater loss of developing fetuses and decreased ossification of hind- and fore-limbs of the fetuses. No adverse effects were observed at the next lowest dose, 600 mg/kg body weight per day. 21