Persivate belongs to a group of medicines called corticosteroids. It is sometimes referred to simply as an oral steroid.
Carcinogenesis, Mutagenesis, Impairment of Fertility
Long-term animal studies have not been performed to evaluate the carcinogenic potential of Persivate dipropionate.
Persivate was negative in the bacterial mutagenicity assay ( Salmonella typhimurium and Escherichia coli ), and in the mammalian cell mutagenicity assay (CHO/HGPRT). It was positive in the in-vitro human lymphocyte chromosome aberration assay, and equivocal in the in-vivo mouse bone marrow micronucleus assay. This pattern of response is similar to that of dexamethasone and hydrocortisone.
Reproductive studies with Persivate dipropionate carried out in rabbits at doses of 1.0 mg/kg by the intramuscular route and in mice up to 33 mg/kg by the intramuscular route indicated no impairment of fertility except for dose-related increases in fetal resorption rates in both species. These doses are approximately 0.5 and 4 fold the estimated maximum human dose based on a mg/m 2 comparison, respectively.
An equal mixture of two Persivate salts, Celestone Soluspan, allows for both immediate and delayed corticosteroid responses. Persivate sodium phosphate acts within hours, whereas Persivate acetate is a suspension that is slowly absorbed over approximately 2 weeks. Persivate (Celestone Soluspan) is approved for intraarticular or soft tissue injection to provide short-term adjuvant therapy in osteoarthritis, tenosynovitis, gouty arthritis, bursitis, epicondylitis, and rheumatoid arthritis. 15 It is also commonly employed in epidural injections. Typical intraarticular doses vary with the size of the joint and range from 0.25 to 2 mL (1.5 mg to 12 mg). Typically epidural injections range from 1 to 3 mL (6 to 18 mg). Persivate should not be mixed with local anesthetics that contain preservatives such as methylparaben as these may cause flocculation of the steroid.
What causes vaginal odour after sex?
Can you lower cholesterol through diet alone?
Quiz: Am I pregnant?
Gallstones diet sheet
When it feels like something is stuck in your throat
This is what cold weather does to your heart
How to support someone through a panic attack
What to do if you're struggling with your mental health at Christmas
When should you worry about neck pain?
Quiz: When will I get my first period?
Quiz: Am I depressed?
The best way to treat a herpes outbreak
When to worry about spots on the penis
Quiz: Do I have diabetes?
What causes head pressure and brain fog?
Meningitis symptoms checklist
What causes extremely smelly farts?
Quiz: Do I have OCD?
Should you worry about pelvic pain in pregnancy?
Why you constantly need to pee
What causes a musty smell in the nose?
What causes a lump on the tongue?
Symptoms you need to stop hiding from your doctor
How to have a healthy Christmas party
How to drink sensibly over the festive season
What your constant yawning could mean
Gout diet sheet
The respiratory system
Oesophageal reflux diet sheet
Oral steroids like Persivate are used to treat a wide variety of conditions. Some examples include autoimmune diseases (for example, systemic lupus erythematosus, autoimmune hepatitis, sarcoidosis); joint and muscle diseases (for example, rheumatoid arthritis); and allergies and asthma. They are also used in the treatment of some cancers. Persivate works by interfering with the release of certain chemicals in the body which cause inflammation.
Persivate is also prescribed as a replacement treatment for people who are not producing enough natural corticosteroid in their bodies due to an adrenal gland disorder called congenital adrenal hyperplasia (CAH).
What is Persivate?
Persivate dipropionate is the generic name of Diprolene and Diprolene AF, used to relieve skin discomfort caused by rashes, itching, and irritation.
Persivate comes in a topical cream, lotion, and ointment, as well as a solution for injection. It has many uses, depending on the form your doctor prescribes.
Although Persivate topical cream and lotion are used to treat irritation and inflammation of the skin, doctors prescribe the injectable form of Persivate, Celestone Soluspan, for multiple sclerosis flares and to help mature the lungs of babies born prematurely.
Other uses of various forms of Persivate include treating the following allergic reactions:
- seasonal allergies
- transfusion reactions
- rashes, eczema, and contact dermatitis on areas of the skin that have touched certain substances
Persivate is in a class of drugs known as steroids. It's not clear how Persivate works, but scientists know that it stops your body from producing certain proteins that cause inflammation and allergic reactions.
The Food and Drug Administration (FDA) originally approved Persivate under the brand name Celestone in 1961, and Schering Pharmaceuticals manufactured the drug.
This original version of Celestone is no longer on the market. However, Celestone Soluspan injectable was approved by the FDA in 1965 and Diprolene was approved in 1983. Both are manufactured by Merck.
What Is Persivate Topical?
Persivate is a steroid that prevents the release of substances in the body that cause inflammation.
Persivate topical (for the skin) is used to treat the inflammation and itching caused by a number of skin conditions such as eczema or psoriasis.
Persivate topical may also be used for purposes not listed in this medication guide.
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
You should not use Persivate topical if you are allergic to it.
Tell your doctor if you have ever had:
- liver disease;
- diabetes; or
- any type of skin infection.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.
It may not be safe to breast-feed a baby while you are using this medicine. Ask your doctor about any risks.
Do not use Persivate topical on a child without a doctor's advice. Children can absorb larger amounts of this medicine through the skin and may be more likely to have side effects.
Diprolene is not approved for use by anyone younger than 13 years old. Sernivo and Luxiq are not approved for anyone younger than 18 years old.