Panalene cream


  • Active Ingredient: Adapalene
  • 15gr
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What is Panalene?

The active ingredient of Panalene brand is adapalene.

Used for

Panalene is used to treat diseases such as: Acne.

Side Effect

Possible side effects of Panalene include: itching of skin; redness of skin; Worsening of acne; dryness and peeling of skin; Burning sensation or stinging of skin.

How to Buy Panalene gel online?

To get Panalene online - simply click on the "Buy Now" button in the top and follow on to our store. Payment and Order takes a couple of minutes, and all measures are obvious. We do not take a medical prescription and we have many methods of payment. With each detail of fast delivery and confidentiality, you can read on the applicable pages on the hyperlinks from the top menu.

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Panalene Side Effects

When first used, Panalene can cause dryness, redness and irritation for some individuals. This irritation usually lessens after the first 4 weeks of continued use, however. In some instances acne may appear worse for a short time. If this occurs, you can try a gentle, non-comedogenic moisturizer, preferably one with sunscreen protection, to counteract the dryness. If irritation becomes severe (overly bothersome), stop use and ask a doctor before using the product again.

Finally, women who are pregnant or breastfeeding should consult a doctor before using Panalene as an acne treatment.

Allergic/ Hypersensitivity Reactions

Reactions characterized by symptoms such as pruritus, face edema, eyelid edema, and lip swelling, requiring medical treatment have been reported during postmarketing use of Panalene. A patient should stop using Panalene Gel, 0.3% and consult a doctor if experiencing allergic or anaphylactoid/anaphylactic reactions (e.g., skin rash, pruritus, hives, chest pain, edema, and shortness of breath) during treatment.

Practical Tips

To ensure the optimal results, there are some things you should do (and not do) when using Panalene:

  • Use a moisturizer. Panalene will most likely dry you out. Apply a moisturizer, oil-free so as not to trigger breakouts, whenever needed.
  • Apply sunscreen. Panalene can also make your skin more sensitive to the sun, so no laying out and no tanning beds. If you’re not already using sunscreen, why not start now? Doing so can protect your skin from sun damage and aging.
  • Avoid waxing. Do you get your eyebrows or lips waxed? You'll want to stop these beauty treatments while using Panalene or risk serious irritation and possible injury to the skin. Tweezing is okay.

Finally, if you have any questions or concerns, don't hesitate to call your dermatologist’s office. In some case, the doctor may be able to suggest alternatives that are more appropriate to your skin type.



OTHER NAME(S): Panalene Solution

This medication is used to treat acne. It may decrease the number and severity of acne pimples and promote quick healing of pimples that do develop. Panalene belongs to a class of medications called retinoids. It works by affecting the growth of cells and decreasing swelling and inflammation.

What’s Panalene and how does it work?

Panalene is the active ingredient in Differin ® Gel. It’s a multi-benefit, dermatologist-recommended retinoid specifically used for clearing acne. Panalene treats acne deep in the pores at the source, prevents new acne from forming and, as a result of reduced acne, restores your skin’s natural texture and tone. Panalene has been prescribed to more than 40 million people over the last 20 years. With Differin Gel, acne sufferers now have access to this effective treatment without a prescription.

Clinical Studies

The safety and efficacy of once daily use of Panalene Gel, 0.3% for treatment of acne vulgaris were assessed in one 12 week, multi-center, controlled, clinical study, conducted in a total of 653 patients 12 to 52 years of age with acne vulgaris of mild to moderate severity. All female patients of child-bearing potential enrolled in the study were required to have a negative urine pregnancy test at the beginning of the study and were required to practice a highly effective method of contraception during the study. Female patients who were pregnant, nursing or planning to become pregnant were excluded from the study.

Patients enrolled in the study were Caucasian (72%), Hispanic (12%), African-American (10%), Asian (3%), and other (2%). An equal number of males (49.5%) and females (50.5%) enrolled. Success was defined as “Clear” or “Almost Clear” in the Investigator’s Global Assessment (IGA). The success rate, mean reduction, and percent reduction in acne lesion counts from Baseline after 12 weeks of treatment are presented in the following table:

Nursing Mothers

It is not known whether Panalene is excreted in human milk. Because many drags are excreted in human milk, caution should be exercised when DIFFERIN Gel, 0.3% is administered to a nursing woman.

Possible Side Effects

Panalene tends to be less irritating than other topical retino > . These are some of the most common:

  • Dryness, peeling, or flaking
  • Redness and irritation
  • Mild burning, stinging, or itching

These side effects are usually at their worst during the first few weeks of treatment and diminish somewhat over time. If Panalene causes anything more than mild irritation, let your dermatologist know.

On rare occasion, Panalene may cause an allergic reaction, known a contact dermatitis. It will often be mild and transient, resolving on its own with no treatment. At other times, it may cause a severe, all-body reaction known as anaphylaxis require emergency medical treatment.


The patient should have a reassessment for efficacy in 12 weeks, or sooner if adverse effects occur.

Panalene is pregnancy category C and should be avoided in pregnant patients as systemic retinoids are teratogenic. It is unknown whether Panalene is excreted in breast milk and thus requires caution in breastfeeding patients.


Panalene is a synthetic naphthoic acid derivative with retinoid activity. The chemical name of Panalene is 6--2-naphthoic acid. Panalene is a white to off-white powder which is soluble in tetrahydrofuran, sparingly soluble in ethanol, and practically insoluble in water. The molecular formula is C28H28O3 and molecular weight is 412.52. Panalene is represented by the structural formula represented on Figure 1 .

Nursing Mothers

It is not known whether Panalene is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Panalene Gel, 0.3% is administered to a nursing woman.

Indications and Usage for Panalene

Panalene Gel, 0.3% is indicated for the topical treatment of acne vulgaris in patients 12 years of age and older.

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