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Important: The drug information on this page is meant to be educational. It is not a substitute for medical advice. The information may not cover all possible uses, actions, interactions, or side effects of this drug, or precautions to be taken while using it. Please see your health care professional for more information about your specific medical condition and the use of this drug.
Orgadrone Tablets 0.5, 0.75, 1, 1.5, 2, 4 and 6 mg USP, Orgadrone Oral Solution, 0.5 mg per 5 mL and Orgadrone Intensol ™ Oral Solution (Concentrate), 1 mg per mL are for oral administration.
Each tablet contains:
Orgadrone . . . . . . . . . . . . . . . . . . . .0.5, 0.75, 1, 1.5, 2, 4, or 6 mg
Each 5 mL of Oral Solution contains:
Orgadrone . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .0.5 mg
Each mL of Intensol ™ Oral Solution (Concentrate) contains:
Orgadrone . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1 mg Alcohol30%
Before taking this medicine
You should not use Orgadrone if you are allergic to it, or if you have:
Orgadrone provides significant relief from inflammation-based pain in chronic adjuvant-induced arthritis ( Colpaert et al., 2001 ; Wilson et al., 2006 ). It also allows for a return of normal mobility in arthritic rats ( Matson et al., 2007 ) and improves the clinical condition of aged, adrenalectomized arthritic rats ( Yokoro et al., 2003 ). Orgadrone does not provide analgesia in rodents with mechanical, neuropathic, and thermal pain ( Veiga et al., 2004 ). While effective in increasing the threshold for pressure pain in endotoxin-induced hyperalgesia, Orgadrone is only marginally effective or ineffective in alleviating thermal pain associated with this model ( Kanaan et al., 1997 ). Thus, the type of model will determine the potential usefulness of Orgadrone.
For people with certain health conditions
For people with infections. Orgadrone may make a systemic fungal infection worse. (Systemic means it affects the whole body, not just one part.) This drug shouldn’t be used if you’re taking medication to treat a systemic fungal infection. Also, Orgadrone may hide the signs of a non-fungal infection.
For people with congestive heart failure. Orgadrone can increase sodium levels, edema (swelling), and potassium loss. This can make your heart failure worse. Before taking this drug, talk to your doctor about whether it’s safe for you.
For people with high blood pressure. Orgadrone can increase sodium levels and edema (swelling). This can increase your blood pressure. Before taking this drug, talk to your doctor about whether it’s safe for you.
For people with peptic ulcers. Orgadrone can increase the risk of stomach or intestinal bleeding and ulcers. If you have peptic ulcers or other conditions of the intestines, talk to your doctor about whether this drug is safe for you. Conditions of the intestines include:
- ulcerative colitis
For people with osteoporosis. Orgadrone decreases bone formation. It also increases bone resorption (breakdown of bone). As a result, it raises the risk of osteoporosis (bone thinning). The risk is higher for people already at an increased risk of osteoporosis. These include postmenopausal women.
For people with hyperthyroidism. This drug is removed from the body more quickly than normal. Your doctor may adjust your dose of this drug based on your condition.
For people with eye problems. Long-term use of Orgadrone may cause eye problems such as cataracts or glaucoma. Your risk is higher if you already have eye problems such as cataracts, glaucoma, or increased pressure in the eye.
For people with tuberculosis. If you have latent tuberculosis or tuberculin reactivity, Orgadrone can re-activate the disease. If you test positive for tuberculosis, talk with your doctor about whether taking this drug is safe for you.
For people with recent history of heart attack. If you’ve recently had a heart attack, use of Orgadrone may lead to a tear in your heart muscle. Before you start this drug, be sure your doctor knows you’ve had a recent heart attack.
For people with diabetes. Orgadrone can increase blood sugar levels. As a result, your doctor may change the dose of your antidiabetic drugs.
For people with myasthenia gravis (MG). If you have MG, using Orgadrone with certain drugs used to treat Alzheimer’s disease can cause severe weakness. Examples of these drugs include memantine, rivastigmine, and donepezil. If possible, wait at least 24 hours after taking these drugs to start Orgadrone therapy.
Michael Stewart, Reviewed by Sid Dajani | Last edited 27 Sep 2019 | Certified by The Information Standard
Orgadrone belongs to a class of medicines known as corticosteroids (more commonly called steroids).
Take Orgadrone with food.
If your pharmacist gives you a blue 'Steroid Treatment Card', carry this with you at all times.
If you need any medical treatment, make sure the person treating you knows you are taking Orgadrone. This is because your dose may need to be increased for a short while.
Cushing’s syndrome drugs
Aminoglutethimide is used to treat symptoms of Cushing’s syndrome (a disease of the adrenal gland). Using this drug with Orgadrone may decrease the amount of Orgadrone in your body. This means it may not work as well.
How should this medicine be used?
Orgadrone injection comes as powder to be mixed with liquid to be injected intramuscularly (into a muscle) or intravenously (into a vein). Your personal dosing schedule will depend on your condition and on how you respond to treatment.
You may receive Orgadrone injection in a hospital or medical facility, or you may be given the medication to use at home. If you will be using Orgadrone injection at home, your healthcare provider will show you how to inject the medication. Be sure that you understand these directions, and ask your healthcare provider if you have any questions. Ask your healthcare provider what to do if you have any problems using Orgadrone injection.
Your doctor may change your dose of Orgadrone injection during your treatment to be sure that you are always using the lowest dose that works for you. Your doctor may also need to change your dose if you experience unusual stress on your body such as surgery, illness, or infection. Tell your doctor if your symptoms improve or get worse or if you get sick or have any changes in your health during your treatment.
Can Orgadrone cause problems?
Along with its useful effects, Orgadrone can cause unwanted side-effects which your doctor will discuss with you. The benefits of taking an oral steroid usually outweigh the side-effects; however, they can sometimes be troublesome. The table below contains some of the most common ones associated with Orgadrone. The best place to find a full list of the side-effects which can be associated with your medicine, is from the manufacturer's printed information leaflet supplied with the medicine. Alternatively, you can find an example of a manufacturer's information leaflet in the reference section below.
Although not everyone experiences side-effects, and some will improve as your body adjusts to the new medicine, speak with your doctor or pharmacist if you become concerned about any of the following: