Optipred tablets


  • Active Ingredient: Prednisolone
  • 40 mg, 20 mg, 10 mg, 5 mg
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What is Optipred?

The active ingredient of Optipred brand is prednisolone. Prednisolone is a steroid that prevents the release of substances in the body that cause inflammation. C21H28O5 M.W. 360.45 Prednisolone Oral Solution USP, 15 mg per 5 mL contains 15 mg of prednisolone in each 5 mL. Benzoic acid, 0.1% is added as a preservative. It also contains alcohol 5%, citric acid, edetate disodium, glycerine, propylene glycol, purified water, sodium saccharin, sucrose, artificial wild cherry flavor, FD&C Blue #1 and Red #40.

Used for

Optipred is used to treat diseases such as: Asthma, acute, Bronchopulmonary Dysplasia, Bullous Pemphigoid, Dermatitis, Immunosuppression, Inflammatory Conditions, Multiple Sclerosis, Nephrotic Syndrome, Pemphigoid, Pemphigus.

Side Effect

Possible side effects of Optipred include: cough or hoarseness; sweating; nausea; vomiting of material that looks like coffee grounds; facial hair growth in females; bloody, black, or tarry stools; noisy, rattling breathing; loss of appetite.

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Optipred is an adrenocortical steroid used for multiple conditions including endocrine disorders, rheumatic disorders, collagen diseases, skin diseases, allergies, eye diseases, respiratory diseases, blood disorders, cancers, edematous states, gastrointestinal diseases, and nervous system disorders, among others. The brand name of this medication is discontinued, but generic versions may be available. Common side effects of Optipred include:

  • infections,
  • heartburn,
  • trouble sleeping (insomnia),
  • hunger,
  • nausea,
  • headache,
  • dizziness,
  • menstrual period changes,
  • increased sweating,
  • acne, and
  • nervousness

The initial dosage of Optipred varies from 5 mg to 60 mg per day depending on the disease being treated. Optipred may interact with other drugs. Tell your doctor all medications and supplements you use. During pregnancy, Optipred should be used only if prescribed. Consult your doctor before breastfeeding.

Our Optipred Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Q: I've beening taking Asthmanol F and Optipred for the past ten years for asthma cough. What adverse effect does it have on me?

A: According to the US Food and Drug Administration, Optipred, which is an oral steroid used in asthma to reduce inflammation in the lungs, has the following common side effects: acne, clumsiness, dizziness, facial flushing (redness), feeling of a whirling motion, general body discomfort, headache, increased appetite, increased sweating, nausea, nervousness, sleeplessness, upset stomach. These are just some of the potential side effects. I have provided links below to additional information about side effects related to Optipred. If you are experiencing bothersome side effects from long term use of Optipred, consult your doctor to discuss the long term risks and benefits of continuing to use this medication. As for Asthmanol F, unfortunately I am not able to provide much information about it because it is not a drug that is approved for use in the United States by the US Food and Drug Administration. //www.everydayhealth.com/drugs/Optipred //www.everydayhealth.com/asthma/guide/ Leslie Ako-Mbo, PharmD

Before using Optipred eye drops or eye ointment,

  • tell your doctor and pharmacist if you are allergic to Optipred or any other drugs.
  • tell your doctor and pharmacist what prescription and nonprescription medications you are taking, including vitamins.
  • tell your doctor if you have or have ever had glaucoma or diabetes.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using Optipred eye drops or eye ointment, call your doctor immediately.

Serious allergic reaction

In rare cases, it's possible to have a serious allergic reaction (anaphylaxis) to Optipred.


The initial dosage of Optipred (Optipred (Optipred (Optipred tablets) tablets) tablets) tablets may vary from 5 mg to 60 mg per day depending on the specific disease entity being treated. In situations of less severity, lower doses will generally suffice, while in selected patients higher initial doses may be required. The initial dosage should be maintained or adjusted until a satisfactory response is noted. If after a reasonable period of time there is a lack of satisfactory clinical response, Optipred (Optipred (Optipred (Optipred tablets) tablets) tablets) should be discontinued and the patient transferred to other appropriate therapy.


After a favorable response is noted, the proper maintenance dosage should be determined by decreasing the initial drug dosage in small increments at appropriate time intervals until the lowest dosage which will maintain an adequate clinical response is reached. It should be kept in mind that constant monitoring is needed in regard to drug dosage. Included in the situations which may make dosage adjustments necessary are changes in clinical status secondary to remissions or exacerbations in the disease process, the patient's individual drug responsiveness, and the effect of patient exposure to stressful situations not directly related to the disease entity under treatment; in this latter situation it may be necessary to increase the dosage of Optipred (Optipred (Optipred (Optipred tablets) tablets) tablets) for a period of time consistent with the patient's condition. If after long-term therapy the drug is to be stopped, it is recommended that it be withdrawn gradually rather than abruptly.

1. About Optipred

Optipred is a type of medicine known as a corticosteroid or steroid. Corticosteroids are not the same as anabolic steroids.

Optipred is used to treat a wide range of health problems including allergies, blood disorders, skin diseases, infections, certain cancers and to prevent organ rejection after a transplant.

It helps by reducing inflammation. It also damps down your immune system, which can help in autoimmune illnesses like rheumatoid arthritis, where your immune system mistakenly attacks its own tissues.

Optipred is available only on prescription as tablets and as a liquid to drink. It can also be given by injection but this is usually only done in hospital.


Do not stop taking Optipred without talking to your doctor - you will need to reduce the dose gradually.

Taking Optipred for many months or years can have several harmful effects on your body. It can lead to:

  • thinner bones (osteoporosis)
  • poorly controlled diabetes
  • eyesight problems
  • slower growth in children and teenagers

If you have to take Optipred for a long time, there are steps you can take to stay as healthy as possible:

  • Take regular exercise and make sure you get enough calcium in your diet to help strengthen your bones. Calcium-rich foods include milk, cheese and leafy greens. To check your bones, your doctor may arrange for you to have an occasional bone scan.
  • If you have diabetes, you may need to check your blood glucose more often. Your doctor can advise you more about this.
  • To reduce the chances of eyesight problems, visit an optometrist every 12 months to check for high pressure in your eye (glaucoma) and cataracts.
  • Make sure that children and teenagers have their height monitored regularly by a doctor so that any stunting of growth can be picked up promptly.

Taking Optipred makes you more likely to catch infections such as flu, the common cold and chest infections.

Keep away from people with an infectious disease, especially chickenpox or shingles. If you have never had these illnesses they could make you very ill.

Optipred and Alcohol

Drinking alcohol may raise your risk of developing stomach bleeding while using Optipred.

Avoid alcohol while taking this medicine.

What other drugs will affect Optipred?

Other drugs may interact with Optipred, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Q: I am a diabetic, and my doctor prescribed methylOptipred for a cold and cough. My normal blood pressure is 132/81. Since I took the medication, my blood pressure went up to 187/88. Is that normal?

A: According to Lexi-Comp, hypertension or high blood pressure is a possible adverse reaction of methylOptipred. It is important to talk to your physician about your elevated blood pressure, especially since you are reporting such high readings. Your physician will best be able to provide you with guidance about this possible medication side effect. Jen Marsico, RPh

By Lynn Marks | Medically Reviewed by Robert Jasmer, MD

Latest Update: 2016-09-19 Copyright © 2014 Everyday Health Media, LLC

Serious Side Effects of Optipred

Tell your doctor right away if you experience any of the following serious side effects:

What should I avoid while taking Optipred?

Do not receive a "live" vaccine while using Optipred. The vaccine may not work as well during this time, and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

Do not receive a smallpox vaccine or you could develop serious complications.

Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chickenpox or measles. These conditions can be serious or even fatal in people who are using steroid medication.

6. How to cope with s >

What to do about:

  • weight gain - try to eat well without increasing your portion sizes so you don't gain too much weight. Regular exercise will also help to keep your weight stable.
  • indigestion - take Optipred with food to reduce the chances of stomach problems. It may also help if you avoid rich or spicy food while you're taking this medicine. If symptoms carry on, ask your doctor if you may benefit from taking an additional medicine to protect your stomach.
  • sleep problems - take Optipred in the morning so the levels are the lowest at bedtime
  • restlessness - if you're restless when you're trying to sleep, take Optipred in the morning so the levels are the lowest at bedtime
  • sweating a lot - try wearing loose clothing, use a strong anti-perspirant and keep cool with a fan. If this doesn't help, talk to your doctor as you may be able to try a different medicine.

Optipred Interactions

Tell your doctor about all prescription, nonprescription, illegal, recreational, herbal, nutritional, or dietary drugs you're taking, especially:

  • Aspirin
  • Diuretics (water pills)
  • Blood thinners, such as Coumadin (warfarin)
  • Gengraf, Neoral, or Sandimmune (cyclosporine)
  • Chemotherapy
  • Insulin or any other diabetes medication
  • Nizoral (ketoconazole)
  • Rifadin, Rifater, Rifamate, or Rimactane (rifampin)
  • Seizure medicines, such as Dilantin (phenytoin) or Solfoton (phenobarbital)
  • Oral contraceptives (birth control pills)
  • St. John's wort

*Do not stop taking this drug without talking to your doctor. You’ll need to taper off the drug slowly to avoid withdrawal symptoms such as weakness, fatigue, loss of appetite, weight loss, nausea, vomiting, and diarrhea.

Optipred and prednisone cost about the same. Both drugs come in generic and brand-name versions. Like all drugs, the generic versions usually cost less. GoodRx.com can give you an idea of the current cost of the drug your doctor prescribes.

However, not all generics are available in the same forms or strengths as the brand-name versions. Ask your healthcare provider if it’s necessary for you to take the brand-name strength or form.

Most pharmacies stock the generic versions of both prednisone and Optipred. The brand-name versions aren’t always stocked, so call ahead before you fill your prescription if you take a brand-name version.

Most insurance plans also cover both prednisone and Optipred. However, your insurance company may require a prior authorization from your doctor before they approve the prescription and cover the payment.

These drugs are from the same drug class and work in a similar way. Because of this, the side effects of prednisone and Optipred are also similar. However, they do differ in a couple of ways. Prednisone may cause your mood to change and may make you feel depressed. Optipred may cause convulsions.

What are the side effects of Optipred?

Optipred side effects depend on the dose, the duration and the frequency of administration. Short courses of Optipred - days to a week or two - are usually well tolerated with few and mild side effects. Long-term, high doses of Optipred will usually produce predictable and potentially serious side effects. Whenever possible, the lowest effective doses of Optipred should be used for the shortest length of time to minimize side effects. Alternate day dosing can also help reduce side effects.

Side effects of Optipred and other corticosteroids range from mild annoyances to serious irreversible damage. Side effects include

  • fluid retention,
  • weight gain,
  • high blood pressure,
  • potassium loss,
  • headache,
  • muscle weakness,
  • puffiness of and hair growth on the face,
  • thinning and easy bruising of the skin,
  • glaucoma,
  • cataracts,
  • peptic ulceration,
  • worsening of diabetes,
  • irregular menses,
  • growth retardation in children,
  • convulsions, and
  • psychic disturbances. (Psychic disturbances can include depression, euphoria, insomnia, mood swings, personality changes, and even psychotic behavior.)

Optipred and other corticosteroids can mask signs of infection and impair the body's natural immune response to infection. Patients on corticosteroids are more susceptible to infections and can develop more serious infections than healthy individuals. For instance, chickenpox and measles viruses can produce serious and even fatal illnesses in patients on high doses of Optipred. Live virus vaccines, such as smallpox vaccine, should be avoided in patients taking high doses of Optipred, since even vaccine viruses may cause disease in patients taking Optipred. Some infectious organisms, such as tuberculosis (TB) and malaria, can remain dormant in a patient for years. Optipred and other corticosteroids can reactivate dormant infections in these patients and cause serious illnesses. Patients with dormant TB may require anti-TB medications while undergoing prolonged corticosteroid treatment.

By interfering with the patient's immune response, Optipred can impede the effectiveness of vaccinations. Optipred can also interfere with the tuberculin skin test and cause false negative results in patients with tuberculosis infection.

Optipred impairs calcium absorption and new bone formation. Patients on prolonged treatment with Optipred and other corticosteroids can develop thinning of bone (osteoporosis) and an increased risk of bone fractures. Supplemental calcium and vitamin D are encouraged to slow this process of bone thinning. In some patients, medications used to treat osteoporosis may be prescribed. In rare individuals, destruction of large joints (osteonecrosis) can occur while undergoing treatment with Optipred or other corticosteroids. These patients experience severe pain in the involved joints, and can require replacement of joints. The reason behind such destruction is not clear.

What Is Optipred (Orapred)?

Optipred is a prescription medicine sold under the brand name Orapred, among other names.

It's used to treat a variety of conditions, including:

  • Allergies
  • Asthma and other breathing disorders
  • Skin problems
  • Ulcerative colitis (a chronic, inflammatory bowel disease)
  • Kidney problems
  • Arthritis
  • Lupus (an autoimmune disease characterized by inflammation and a variety of symptoms)
  • Psoriasis (a skin condition)
  • Multiple sclerosis (a disease that causes weakness, numbness, loss of coordination, and other problems because nerves in the body don't function properly)
  • Adrenal problems
  • Eye conditions
  • Blood or bone marrow problems

Optipred is a corticosteroid. It works by stopping the release of substances in the body that cause inflammation.

The Food and Drug Administration (FDA) first approved Optipred in 1955. It's marketed by various pharmaceutical companies.

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