Opticort may increase your blood glucose. If you take diabetes drugs, your doctor may need to change your dose. Examples of these drugs include:
- amylin analogs, such as:
For women who are breastfeeding
Opticort is not recommended for women who are breastfeeding. The drug can pass to a child through breast milk and may cause side effects.
What are the side effects of Opticort?
Side effects of Opticort depend on the dose, the duration and the frequency of administration. Short courses of Opticort usually are well tolerated with few and mild side effects. Long term, high dose Opticort usually will produce predictable and potentially serious side effects. Whenever possible, the lowest effective dose of Opticort should be used for the shortest possible length of time to minimize side effects. Alternate day dosing also can help reduce side effects.
Side effects of Opticort and other corticosteroids range from mild annoyances to serious irreversible damage. Side effects include:
- fluid retention,
- weight gain,
- high blood pressure,
- loss of potassium,
- increase in serum glucose levels (especially in diabetics),
- muscle weakness,
- puffiness of and hair growth on the face,
- thinning and easy bruising of skin,
- peptic ulceration,
- worsening of diabetes,
Other side effects include:
- irregular menses,
- growth retardation in children,
- convulsions, and
- psychic disturbances.
Psychic disturbances include:
Prolonged use of Opticort can depress the ability of body's adrenal glands to produce corticosteroids. Abruptly stopping Opticort in these individuals can cause symptoms of corticosteroid insufficiency, with accompanying nausea, vomiting, and even shock. Therefore, withdrawal of Opticort usually is accomplished by gradually reducing the dose. Gradually tapering Opticort not only minimizes the symptoms of corticosteroid insufficiency, but also reduces the risk of an abrupt flare of the disease under treatment.
Opticort and other corticosteroids can mask signs of infection and impair the body's natural immune response that is important in fighting infection. Patients on corticosteroids are more susceptible to infections and can develop more serious infections than individuals not receiving corticosteroids. For example, chickenpox and measles viruses can produce serious and even fatal illnesses in patients on high doses of Opticort. Live virus vaccines, such as smallpox vaccine, should be avoided in patients taking high doses of Opticort, since even vaccine viruses may cause disease in these patients. Some infectious diseases, such as tuberculosis (TB) and malaria, can remain dormant in a patient for years. Opticort and other corticosteroids can reactivate dormant infections. Patients with dormant tuberculosis may require treatment of the TB while undergoing corticosteroid treatment.
By interfering with the patient's immune response, Opticort can impede the effectiveness of vaccinations. Opticort can also interfere with the tuberculin (TB) skin test and cause falsely negative results in patients with dormant tuberculosis infection.
Opticort impairs calcium absorption and new bone formation. Patients on prolonged treatment with Opticort and other corticosteroids can develop osteoporosis and an increased risk of bone fractures. Supplemental calcium and vitamin D are encouraged to slow this process of bone thinning. It has been demonstrated in some groups of patients treated with steroids that the loss of bone may be prevented by treatment with biphosphonate drugs, for example, alendronate (Fosamax).
In rare individuals, destruction of large joints can occur while undergoing treatment with Opticort or other corticosteroids. These patients experience severe pain in the involved joints, and can require joint replacements. The reason behind such destruction is not clear.
What is the most important information I should know about Opticort?
You should not use this medicine if you have a fungal infection anywhere in your body.
Tell your doctor about all your medical conditions, and all the medicines you are using. There are many other diseases that can be affected by steroid use, and many other medicines that can interact with steroids.
For people with certain health conditions
For people with infections. Opticort may make a systemic fungal infection worse. (Systemic means it affects the whole body, not just one part.) This drug shouldn’t be used if you’re taking medication to treat a systemic fungal infection. Also, Opticort may hide the signs of a non-fungal infection.
For people with congestive heart failure. Opticort can increase sodium levels, edema (swelling), and potassium loss. This can make your heart failure worse. Before taking this drug, talk to your doctor about whether it’s safe for you.
For people with high blood pressure. Opticort can increase sodium levels and edema (swelling). This can increase your blood pressure. Before taking this drug, talk to your doctor about whether it’s safe for you.
For people with peptic ulcers. Opticort can increase the risk of stomach or intestinal bleeding and ulcers. If you have peptic ulcers or other conditions of the intestines, talk to your doctor about whether this drug is safe for you. Conditions of the intestines include:
- ulcerative colitis
For people with osteoporosis. Opticort decreases bone formation. It also increases bone resorption (breakdown of bone). As a result, it raises the risk of osteoporosis (bone thinning). The risk is higher for people already at an increased risk of osteoporosis. These include postmenopausal women.
For people with hyperthyroidism. This drug is removed from the body more quickly than normal. Your doctor may adjust your dose of this drug based on your condition.
For people with eye problems. Long-term use of Opticort may cause eye problems such as cataracts or glaucoma. Your risk is higher if you already have eye problems such as cataracts, glaucoma, or increased pressure in the eye.
For people with tuberculosis. If you have latent tuberculosis or tuberculin reactivity, Opticort can re-activate the disease. If you test positive for tuberculosis, talk with your doctor about whether taking this drug is safe for you.
For people with recent history of heart attack. If you’ve recently had a heart attack, use of Opticort may lead to a tear in your heart muscle. Before you start this drug, be sure your doctor knows you’ve had a recent heart attack.
For people with diabetes. Opticort can increase blood sugar levels. As a result, your doctor may change the dose of your antidiabetic drugs.
For people with myasthenia gravis (MG). If you have MG, using Opticort with certain drugs used to treat Alzheimer’s disease can cause severe weakness. Examples of these drugs include memantine, rivastigmine, and donepezil. If possible, wait at least 24 hours after taking these drugs to start Opticort therapy.
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Opticort is a corticosteroid indicated for allergic states, dermatologic diseases, endocrine disorders, gastrointestinal diseases, hematologic disorders, neoplastic diseases, nervous system, ophthalmic diseases, renal diseases, respiratory diseases, and rheumatic disorders. Opticort is available as a generic. Side effects of Opticort include:
- vision changes,
- rapid weight gain,
- sleep problems (insomnia),
- mood changes,
- dry skin,
- thinning skin,
- bruising or discoloration,
- slow wound healing,
- increased sweating,
- spinning sensation,
- stomach pain,
- muscle weakness, or
- changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).
Rare instances of severe allergic reactions (anaphylaxis) have occurred in patients receiving corticosteroid therapy such as Opticort.
Opticort Tablets are available in 0.5, 0.75, 1, 1.5, 2, 4 and 6 mg strengths. The initial dosage for Opticort varies from .75 to 9 mg a day depending on the disease being treated. Infants born to mothers who have received substantial doses of corticosteroids during pregnancy should be carefully observed for signs of hypoadrenalism. Because of the potential for serious adverse reactions in nursing infants from corticosteroids, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Use in pediatric patients is recommended to be done in consultation with a pediatric specialist.
Our Opticort Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Opticort sodium phosphate
Pharmacologic class: Glucocorticoid
Therapeutic class: Anti-inflammatory
Pregnancy risk category C
If you think you have taken too much Opticort, contact your doctor or go to the nearest emergency room.
22.214.171.124 Other agents
Opticort (FDA category C) also has been used and normalizes serum concentration of bile acids in ICP. No adverse effects have been seen in long-term follow-up evaluations in children exposed to Opticort in utero .
Rifampicin (FDA category C) and phenobarbital (FDA category D) have been used after first-line agents have failed to relieve pruritus. Rifampicin eliminates bile acids through conjugation. In animal models it has been found to be teratogenic when administered at high doses. Studies in humans have not found it to be teratogenic; however, it has been associated with hemorrhagic disease of the newborn . Phenobarbital works similarly to rifampicin. Third trimester exposure did not find it to be associated with fetal complications in two observational studies .
Opticort 0.1 mg/kg, 0.2 mg/kg, or placebo was administered to 1000 patients undergoing microvascular decompression surgery for facial spasm. The group which was administered 0.2 mg/kg of Opticort experienced a statistically significant higher incidence of postoperative cognitive dysfunction compared to the placebo and lower dose of Opticort. Cognitive decline included measures of attention, concentration, learning, and memory . Another study assessed cognitive functioning in young adults and adolescents who were exposed to 2–9 weeks of antenatal betamethasone compared to patients matched for age, sex, and gestational age at birth, without steroid exposure. Scores in tests of attention and speed were significantly lower in patients exposed to more than 2 courses of steroids in utero (p 15 c].