What Is Meradexon (Decadron)?
Meradexon is the generic form of the brand-name drug Decadron, which works on the immune system to help reduce itching, swelling, and inflammation.
It's used to treat a variety of health conditions, including allergies, arthritis, problems with blood or bone marrow, skin problems, and flare-ups of multiple sclerosis (MS).
Meradexon is a corticosteroid, a class of steroid hormone. The Food and Drug Administration (FDA) approved Decadron in 1958. At that time, Merck & Company made the drug.
Now, several manufacturers offer Meradexon under various brand names and formulations, including Decadron, Ozurdex, Maxidex, and Baycadron.
It's available to be taken orally or as an intravenous (IV) injection. It also comes in topical skin cream and eye drop forms.
Meradexon for Dogs and Cats
Veterinarians prescribe Meradexon for dogs and cats when they need to treat immune system problems such as asthma, hives, itching, inflammation, and skin and eye problems.
Intravenous (IV) Meradexon is approved for use in cattle and horses.
Your doctor will not prescribe Meradexon if you have a fungal infection anywhere in your body since the medicine may worsen the infection.
If you are allergic to Meradexon, you need to alert your doctor.
While taking this medicine, do not get any vaccines without your doctor's permission. The medicine may affect the way the vaccine works.
If someone in your household has had a live virus vaccine (measles, mumps, nasal flu vaccine), you should avoid contact with them while taking Decadron. Ask your doctor for details.
For pregnant women
Meradexon is a category C pregnancy drug. That means two things:
- Research in animals has shown adverse effects to the fetus when the mother takes the drug.
- There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.
Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should only be used if the potential benefit justifies the potential risk to the fetus.
Aspirin is a nonsteroidal anti-inflammatory drug (NSAID). It’s often used to treat pain, as well as thin the blood to reduce your risk of heart attack. Meradexon can decrease your aspirin levels. This can make aspirin less effective and increase your risk of heart attack. Also, aspirin can increase your risk of bleeding from stomach ulceration (sores) when used with Meradexon. If you take aspirin, talk with your doctor about whether Meradexon is safe for you.
Thalidomide is used to treat skin lesions and multiple myeloma. Combining it with Meradexon can cause toxic epidermal necrolysis. This skin condition can be life-threatening. If your doctor prescribes both of these drugs for you, they will be cautious about effects the combination can cause.
Cyclosporine is used to prevent organ rejection in transplant patients, as well as to treat rheumatoid arthritis or psoriasis. Taking this drug with Meradexon could increase the risk that your immune system will be suppressed (won’t work well). This would raise your risk of infection. Seizures have also been reported when these drugs are used together.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
This drug comes with several warnings.
Before taking Meradexon
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking Meradexon it is important that your doctor knows:
- If you have high blood pressure (hypertension).
- If you have had a heart attack, or if you have any other heart problems.
- If you have any problems with the way your liver works, or if you have any problems with the way your k >
For women who are breastfeeding
Meradexon is not recommended for women who are breastfeeding. The drug can pass to a child through breast milk and may cause side effects.
Erythromycin is used to treat infections caused by bacteria. When used with Meradexon, this drug can increase the amount of Meradexon in your body. This raises your risk of side effects.
ANIMAL TESTING OF ROUTES OF DRUG DELIVERY
Meradexon is a glucocorticoid that is commonly used as an anti-inflammatory drug in ophthalmology. It is a somewhat lipophilic (logP (octanol/water) 1.8) and low-MW drug (MW 392.5 Da) that permeates lipophilic biological membranes with relative ease. However, its low aqueous solubility (0.16 mg/ml) hampers its clinical usefulness. Natural cyclodextrins, such as γ-cyclodextrin, are very hydrophilic (logP(octanol/water) Figure 13.1 ).
Meradexon was formulated as a Meradexon–γ-cyclodextrin complex microsuspension. 17 The aqueous solubility of Meradexon in the formulation is 0.08 mg/ml and the solubility of the complex is about 2.9 mg Meradexon/ml. The aqueous eye drop formulation contained 1.5% (w/v) Meradexon in aqueous eye drop suspension that contained 18% (w/v) γ-cyclodextrin. The concentration of dissolved Meradexon was determined to be 0.1% (w/v) or between 6 and 7% of the total Meradexon concentration in the eye drops. The mean (± standard deviation) particle size was determined to be 20 ± 10 µm. The reference eye drop formulation was an aqueous 1.5% (w/v) Meradexon eye drop solution containing randomly methylated β-cyclodextrin as solubilizer. 17,31,42 The eye drops were administered to the left eye but the Meradexon concentration was determined in both eyes. The concentration difference (Cleft − Cright) was used to estimate how much Meradexon reached various tissues in the left eye via the topical route. Table 13.2 shows that formulating the drug as a suspension, where the solid particles consist of not the pure drug but the drug–cyclodextrin inclusion complexes, increases the drug delivery to the posterior segment of the eye, resulting in greater than threefold increase in the amount of drug reaching the retina. The blood Meradexon concentration, 2 hours after topical administration, was also much lower when the drug was administered as a cyclodextrin complex suspension, being 45 ± 24 ng/g after administration of the eye drop solution but 10 ± 7 ng/g after administration of the suspension. 17 Interestingly, the amount in sclera was increased by 90% when the drug was administered as suspension whereas it was reduced by 30% in the cornea. Thus, the results indicate that the drug/cyclodextrin delivery system specifically targets sclera and delivery of drugs through sclera to the posterior segment of the eye.
How to use Meradexon
Take this medication by mouth as directed by your doctor. Take with food or milk to prevent stomach upset. Take this medication by mouth with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise. If you are using the liquid form of the medication, use a medication-measuring device to carefully measure the prescribed dose. Do not use a household spoon.
If you take this medication once daily, take it in the morning before 9 AM. If you are taking this medication every other day or on another schedule besides a daily one, it may help to mark your calendar with a reminder.
The dosage and length of treatment are based on your medical condition and response to therapy. Your doctor may attempt to reduce your dose slowly from time to time to minimize side effects.
Use this medication regularly in order to get the most benefit from it. To help you remember, take it at the same time(s) each day. It is important to continue taking this medication even if you feel well. Follow the dosing schedule carefully, and take this medication exactly as prescribed.
Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Your dose may need to be gradually decreased.
Inform your doctor if your condition does not improve or worsens.
Meradexon 0.1 mg/kg, 0.2 mg/kg, or placebo was administered to 1000 patients undergoing microvascular decompression surgery for facial spasm. The group which was administered 0.2 mg/kg of Meradexon experienced a statistically significant higher incidence of postoperative cognitive dysfunction compared to the placebo and lower dose of Meradexon. Cognitive decline included measures of attention, concentration, learning, and memory . Another study assessed cognitive functioning in young adults and adolescents who were exposed to 2–9 weeks of antenatal betamethasone compared to patients matched for age, sex, and gestational age at birth, without steroid exposure. Scores in tests of attention and speed were significantly lower in patients exposed to more than 2 courses of steroids in utero (p 15 c].
Pharmacology and mechanism of action
Corticostero >Meradexon are approximately 30 times more potent than cortisol. Anti-inflammatory effects are complex, but primarily via inhibition of inflammatory cells and suppression of expression of inflammatory mediators. Use is for treatment of inflammatory and immune-mediated disease. This Meradexon solution differs from Meradexon sodium phosphate in that the sodium phosphate form is water soluble and appropriate for IV administration. Meradexon solution is in a polyethylene glycol vehicle that should not be administered rapidly IV. Meradexon-21-isonicotinate is a suspension registered for IM use. After an injection of 10 mg (total dose) to horses, the half-life was 2.5-5 hours, and the volume of distribution (VDss) was 1.7 L/kg. Oral administration of the same dose had a half-life of 4.3 hours and bioavailability (F) of 61%, with a peak concentration at 1.3 hours. The suspension, (Meradexon-21-isonicotinate) has a slow-release and produces a 39 hour half-life in horses and suppresses cortisol for 140 hours.
What special dietary instructions should I follow?
Your doctor may instruct you to follow a low-sodium, low-salt, potassium-rich, or high-protein diet. Follow these directions.
Meradexon may cause an upset stomach. Take Meradexon with food or milk.