What is Maxidex, and how does it work (mechanism of action)?
Maxidex is a synthetic (man-made) corticosteroid. Corticosteroids are naturally-occurring chemicals produced by the adrenal glands located above the kidneys. Corticosteroids affect the function of many cells within the body and suppress the immune system. Corticosteroids also block inflammation and are used in a wide variety of inflammatory diseases affecting many organs. The FDA approved Maxidex in October 1958.
When used with Maxidex, certain drugs used to treat epilepsy can lower the level of Maxidex in your blood. This can keep Maxidex from working well. Examples of these drugs include:
Common Side Effects of Maxidex
Increased appetite is one of the commonly reported side effects of Maxidex.
Unless it persists or is bothering you, it does not warrant medical attention. Your appetite may return to normal again once your body adjusts to the medicine.
Other s >Maxidex include:
- Dry scalp
- Hair thinning
- Reddish face, lightening of skin
- Swelling in the abdominal area
- Weight gain
Serious side effects
Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:
- Unusual tiredness
- Unusual dizziness
- stomach pain
- nausea or vomiting
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
Maxidex oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.
To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.
Examples of drugs that can cause interactions with Maxidex are listed below.
Maxidex provides significant relief from inflammation-based pain in chronic adjuvant-induced arthritis ( Colpaert et al., 2001 ; Wilson et al., 2006 ). It also allows for a return of normal mobility in arthritic rats ( Matson et al., 2007 ) and improves the clinical condition of aged, adrenalectomized arthritic rats ( Yokoro et al., 2003 ). Maxidex does not provide analgesia in rodents with mechanical, neuropathic, and thermal pain ( Veiga et al., 2004 ). While effective in increasing the threshold for pressure pain in endotoxin-induced hyperalgesia, Maxidex is only marginally effective or ineffective in alleviating thermal pain associated with this model ( Kanaan et al., 1997 ). Thus, the type of model will determine the potential usefulness of Maxidex.
Michael Stewart, Reviewed by Sid Dajani | Last edited 27 Sep 2019 | Certified by The Information Standard
Maxidex belongs to a class of medicines known as corticosteroids (more commonly called steroids).
Take Maxidex with food.
If your pharmacist gives you a blue 'Steroid Treatment Card', carry this with you at all times.
If you need any medical treatment, make sure the person treating you knows you are taking Maxidex. This is because your dose may need to be increased for a short while.
Pregnancy and Maxidex
Decadron may harm a developing fetus.
You and your doctor will need to determine if the benefits of taking Decadron outweigh the potential risks.
If you become pregnant while taking Decadron, contact your doctor right away.
Corticosteroids appear in breast milk and could hamper a baby’s growth or cause other unwanted side effects.
If you are taking Decadron, your doctor will advise you not to breastfeed.
Using Maxidex with certain medicines is not recommended.
Your doctor may decide to change these other medicines or avoid treating you with Maxidex. These include:
- Artemether with lumefantine (Coartem), an antimalarial drug
- Praziquantel (Biltridice) for parasitic infections
- Rilpivirine (Edurant) for HIV
- Live rotavirus vaccine
Maxidex may also interact with drugs that are used to treat depression and infection.
If you are on any of the following medications, your doctor may change the dose of one or both or change how often you take them:
- Bupropion (Wellbutrin, Zyban, others), an antidepressant
- Clarithromycin (Biaxin), an antibiotic
- Itraconazole (Onmel, Sporanox), an anti-fungal medicine
- Telaprevir (Incivek), for hepatitis C infections
If you are on any antidiabetic drugs, your doctor may need to adjust the doses because the steroids may increase blood sugar concentrations.
If you are on the blood thinner warfarin (Coumadin), your response to warfarin may decline. Your doctor may need to monitor you more often.
Using aspirin or similar pain medication while taking Maxidex may increase your risk of gastrointestinal effects. Ask your doctor about whether you can take both together.
Be sure to tell your doctor about any prescription, non-prescription, over-the-counter (OTC), illegal and recreational drugs, herbal remedies, nutritional and dietary supplements you’re taking before taking Maxidex.
For pregnant women
Maxidex is a category C pregnancy drug. That means two things:
Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should only be used if the potential benefit justifies the potential risk to the fetus.