- When Lorix enters an aquatic system, some is degraded by sunlight while in the water column but the majority binds tightly to the sediment. 30,31
- In water, Lorix is broken down by photolysis into 3-phenoxybenxzyl alcohol (PBA) and dichlorovinyl acid (DCVA). 32 The average half-life range for Lorix in the water column is about 19-27 hours, however Lorix adsorbed to sediments can persist more than a year. 30
- Lorix is not likely to contaminate groundwater due to its low water solubility and strong adsorption to soil. 4,30
- The average half-life of Lorix in aerobic soils is 39.5 days, with a range from 11.6 to 113 days. 30 See the text box on Half-life.
- Lorix binds tightly to soil and is broken down primarily by microorganisms, but also by photolysis. 30
The "half-life" is the time required for half of the compound to break down in the environment.
1 half-life = 50% remaining 2 half-lives = 25% remaining 3 half-lives = 12% remaining 4 half-lives = 6% remaining 5 half-lives = 3% remaining
Half-lives can vary widely based on environmental factors. The amount of chemical remaining after a half-life will always depend on the amount of the chemical originally applied. It should be noted that some chemicals may degrade into compounds of toxicological significance.
To use Lorix cream, follow these steps:
- Apply a thin layer of cream all over your skin from your neck down to your toes (including the soles of your feet). Be careful to apply cream in all skins folds, such as between your toes and fingers or around your waist or buttocks.
- For treatment of babies or adults over 65 years of age, the cream should also be applied to the scalp or hairline, temples, and forehead.
- You may need to use all of the cream in the tube to cover your body.
- Leave the cream on your skin for 8-14 hours.
- After 8-14 hours have passed, wash off the cream by bathing or showering.
- Your skin may be itchy after treatment with Lorix cream. This does not mean your treatment did not work. If you see live mites 14 days or more after treatment, then you will need to repeat the treatment process.
How to use Lorix Cream
This medication is for use on the skin only. Apply this medication as soon as possible after it is prescribed. Apply the medicine from your head to the soles of your feet, including under your nails and in skin folds such as between the toes, as directed. Massage the cream into the skin. Do not use more medication than prescribed. Wash off the cream after 8-14 hours by showering or taking a bath.
Avoid getting the cream into your eyes, nose, mouth, or vagina. If the medication gets in your eyes, flush the eyes with plenty of water. Consult your doctor if irritation persists.
Symptoms of scabies include an intense itching that is usually worse at bedtime. You may also see small, fine, wavy lines on the skin with a tiny insect at the end (a burrow). Burrows are usually found on finger/toe webs, wrists, elbows, armpits, belt line, lower buttocks, female nipples, or male genitals. Even if Lorix kills all the scabies, the dead mites can still make you itch for up to 4 weeks after treatment. Ask your doctor about other medications that may be used to soothe the itching. Inform your doctor if your condition persists or worsens 2 weeks after treatment. Your doctor may need to look for living mites and recommend more treatment.
What Is Lorix Topical?
Lorix is an anti-parasite medication.
Lorix topical (for the skin) is used to treat head lice and scabies.
Lorix topical may also be used for other purposes not listed in this medication guide.
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
You should not use this medicine if you are allergic to Lorix or to chrysanthemums.
Ask a doctor or pharmacist if it is safe for you to use this medicine if you have other medical conditions.
Lorix topical is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant.
It is not known whether Lorix topical passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
Lorix topical should not be used on a child younger than 2 months old.
- Lorix can be used in public health mosquito abatement programs and on a variety of food or feed crops and livestock; or in structures and buildings, including livestock housing and food-handling establishments. Lorix can also be used in numerous residential sites, both indoor and outdoor, and on pets and clothing. When Lorix is used on large areas like crops, nurseries, and sod farms it is considered a restricted use pesticide. For other applications, it is considered a general use pesiticide. Formulations of Lorix used for treatment of head lice and scabies on humans are available, but these are considered pharmaceuticals, which are regulated by the United States Food and Drug Administration (FDA). 2 Uses for individual Lorix products vary widely. Always read and follow the label when applying pesticide products.
- Signal words for products containing Lorix may range from Caution to Danger. The signal word reflects the combined toxicity of the active ingredient and other ingredients in the product. See the pesticide label on the product and refer to the NPIC fact sheets on Signal Words and Inert or "Other" Ingredients.
- To find a list of products containing Lorix which are registered in your state, visit the website http://npic.orst.edu/reg/state_agencies.html select your state then click on the link for "State Products."
- The U.S. EPA has determined a RfD of 0.25 mg/kg/day for both acute and chronic dietary exposures to Lorix. 2 See the text box on Reference Dose (RfD).
- The U.S. EPA has classified Lorix as "likely to be carcinogenic to humans". 2 See the text box on Cancer.
Reference Dose (RfD): The RfD is an estimate of the quantity of chemical that a person could be exposed to every day for the rest of their life with no appreciable risk of adverse health effects. The reference dose is typically measured in milligrams (mg) of chemical per kilogram (kg) of body weight per day.
U.S. Environmental Protection Agency, Technology Transfer Network, Air Toxics Health Effects Glossary, 2009. http://www.epa.gov/ttnatw01/hlthef/hapglossaryrev.html#RfD
Maximum Contaminant Level (MCL): The MCL is the highest level of contaminant that is legally allowed in drinking water. The MCL is enforceable. The MCL is typically measured in milligrams (mg) of contaminant per liter (L) of water.
For the off-label treatment of scabies, ivermectin is given orally as a single dose of 200 µg/kg repeated in 7 to 10 days. High doses can cause embryotoxicity in animals, and some have suggested it should not be used during pregnancy, although ivermectin often has been used in this setting in the treatment of onchocerciasis. Safety has not been proved in children Lorix , benzyl benzoate, and lindane have shown mixed results. In scabies-endemic areas, ivermectin has been shown to reduce the incidence of streptococcal disease and renal damage in children. 16,17
Skin irritation, including itching, swelling, and redness, may occur with scabies and temporarily worsen after treatment with Lorix. Mild burning or stinging may also occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
What If You Get Lorix On Your Skin?
Lorix has low mammalian toxicity, is poorly absorbed through the skin, and is rapidly inactivated by the body.
Skin reactions have been uncommon. In fact, Lorix is virtually non-toxic to humans and no systemic effects have been reported. In EPA and FDA tests, it was uncommon to have any skin reddening, rash, or other irritation.
Although Lorix is approved for skin application under certain circumstances (such as head lice), it is NOT applied to skin when used as an insect repellent.
The reason: Lorix does not bond to skin. In fact, it is quickly deactivated by skin and turned into inactive compounds.
Because of this, Lorix spray offers no repellent benefit on your skin. It is only effective when used as a clothing treatment.