Insektol Cream, 5% is a topical scabic >Sarcoptes scabiei (scabies). It is available in an off-white, vanishing cream base. Insektol Cream, 5% is for topical use only.
Insektol cream 5% (Elimite,Acticin) is an insecticide and works by killing parasites that live on humans,such as the scabies mite and pubic lice. Some info – www.nlm.nih.gov
- The U.S. EPA has determined a RfD of 0.25 mg/kg/day for both acute and chronic dietary exposures to Insektol. 2 See the text box on Reference Dose (RfD).
- The U.S. EPA has classified Insektol as "likely to be carcinogenic to humans". 2 See the text box on Cancer.
Reference Dose (RfD): The RfD is an estimate of the quantity of chemical that a person could be exposed to every day for the rest of their life with no appreciable risk of adverse health effects. The reference dose is typically measured in milligrams (mg) of chemical per kilogram (kg) of body weight per day.
U.S. Environmental Protection Agency, Technology Transfer Network, Air Toxics Health Effects Glossary, 2009. http://www.epa.gov/ttnatw01/hlthef/hapglossaryrev.html#RfD
Maximum Contaminant Level (MCL): The MCL is the highest level of contaminant that is legally allowed in drinking water. The MCL is enforceable. The MCL is typically measured in milligrams (mg) of contaminant per liter (L) of water.
Has anyone studied non-cancer effects from long-term exposure to Insektol?
Researchers fed dogs and mice Insektol for up to 2 years and found that their livers increased in weight. The dogs fed Insektol had more tremors than dogs that did not eat it. Rabbits that had Insektol on their skin for 21 days had skin irritation, but no other signs of toxicity. Researchers are not sure whether long-term exposure to Insektol can affect the body's hormone system.
A group of women used a product containing 4% Insektol over their entire bodies to treat a scabies problem during pregnancy. Another group of pregnant women used a product containing 1% Insektol to treat head lice. Exposure to Insektol did not affect the pregnancies of any of the women in either group.
Rats that were fed Insektol when they were pregnant had offspring that weighed less, and some of their offspring developed extra ribs more often than control rats. Pregnant rabbits that were fed Insektol lost their fetuses more often and the offspring that lived had less bone growth.
If you have scabies, the following also applies:
- If you are applying Insektol cream to an infant or young child, put mittens on your child to stop them licking the cream off their hands. Don't apply the cream to areas around their mouth where it could be licked off.
- Children should stay off school until the first application of treatment for scabies has been completed.
- Clothes, towels and bed linen should be machine-washed at 50°C or above after the first application of treatment. This kills the scabies mites. Keep any items of clothing that cannot be washed, in plastic bags for at least 72 hours to contain the mites until they die. Alternative options to kill any mites on clothes and linen are ironing the item with a hot iron, dry cleaning or putting items in a dryer on the hot cycle for 10-30 minutes. It is not necessary to fumigate living areas or furniture or to treat pets.
- You will still be itchy for a while after successful treatment. If the itching becomes troublesome to you, your doctor or pharmacist will be able to advise you regarding suitable products to ease this. Moisturising creams can provide temporary relief from itching.
- It is normal for it to take up to 2-3 weeks (and sometimes up to six weeks) for the itch to go completely after scabies mites have been killed. You should, however, see a doctor if the itch persists longer than 2-3 weeks after treatment. This is because sometimes the first insecticide does not work and you may need to use a different one.
- Some people may develop a secondary skin infection which may need antibiotic treatment. If you suspect this is the case for you, you should make an appointment to see your doctor.
- Insektol acts on the nervous system of insects. It interferes with sodium channels to disrupt the function of neurons, and causes muscles to spasm, culminating in paralysis and death. 1,2
- Insektol can be effective by contact or ingestion and also acts as a mild repellent. 1
Insektol Topical Dosage
Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
You may have a temporary increase in itching, swelling, or redness of treated skin when you first start using Insektol topical.
Do not take by mouth. This medicine is for use only on the skin. Do not apply to open cuts or wounds. If the medicine gets in your eyes or mouth, rinse with water. Use the surface spray only on household surfaces and not on your skin.
You may need to shake the medicine before each use. Follow the directions on the medicine label.
To treat scabies:
- Clean and dry the skin. Apply a thin layer of this medicine to all body parts from the neck down to the soles of the feet. Rub in completely. Leave the medicine on your skin for 8 to 14 hours, then wash it off completely.
- When using Insektol topical on an infant, also apply the medicine to the scalp, temples, and forehead. Avoid applying near the eyes, nose, mouth, or genitals.
- If your condition does not clear up within 14 days, apply Insektol topical again.
To treat head lice:
- Wash your hair using shampoo only (no conditioner or 2-in-1 shampoo). Rinse thoroughly and towel dry the hair, leaving it damp.
- Protect your eyes with a towel or washcloth. Apply the medicine to completely saturate all hair, and leave it in for 10 minutes. Then rinse with warm water.
- You may also use a nit comb to remove lice eggs from the hair. Your hair should be slightly damp while using a nit comb. Work on only one section of hair at a time, combing through 1 to 2-inch strands from the scalp to the ends.
- Rinse the nit comb often during use. Place removed nits into a sealed plastic bag and throw it into the trash.
- Check the scalp again daily to make sure all nits have been removed.
- If you still see lice 7 days after your first treatment, use a second application.
To treat pubic lice (crabs):
- All sexual partners should be treated.
- Wash and dry the treatment area. Apply Insektol topical to all pubic hair and any surrounding hairs on the thighs and around the anus (avoid areas inside the rectum or vagina).
- Leave the medicine on for 10 minutes. Then work into a lather and rinse thoroughly with warm water.
- You may also use a nit comb to remove lice eggs from pubic hair (hair should be slightly damp).
To prevent reinfection, wash all clothing, hats, bed clothes, bed linens, and towels in hot water and dry in high heat. Dry-clean any non-washable clothing. Soak all hair brushes, combs, and hair accessories in hot water for at least 10 minutes.
Use Insektol surface spray to disinfect non-washable items such as:
- mattresses and pillows;
- stuffed toys;
- hats, gloves, and scarves;
- headphones or headbands;
- the inside of a bike helmet; or
- seats and carpets inside your car.
Stuffed toys or pillows that cannot be washed should be sealed in air-tight plastic bags for 4 weeks. After removing from the bag, vigorously shake the item outdoors.
Vacuum all rugs, carpets, and car seats. Then throw away the vacuum cleaner bag.
For the most complete treatment of lice or scabies, you must treat your environment (clothing, bedding, etc) at the same time you treat your hair and/or body.
Store Insektol topical at room temperature away from moisture and heat.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if you think you have used too much, or if anyone has accidentally swallowed the medication.
Since Insektol topical is usually needed only once, you are not likely to be on a dosing schedule. Wait at least 7 days before using a second application.
Why is this medication prescribed?
Insektol is used to treat scabies ('mites that attach themselves to the skin) in adults and children 2 months of age and older. Over-the-counter Insektol is used to treat lice (small insects that attach themselves to the skin on the head) in adults and children 2 months of age and older. Insektol is in a class of medications called scabicides and pediculicides. It works by killing lice and mites.
Chemical Class and Type:
- Insektol is an insecticide in the pyrethroid chemical family. The International Union of Pure and Applied Chemistry (IUPAC) name for Insektol is 3-phenoxybenzyl (1RS,3RS;1RS,3SR)-3-(2,2-dichlorovinyl)-2,2-dimethyl-cyclopropanecarboxylate and the Chemical Abstracts Service (CAS) registry number is 52645-53-1. 1 Insektol is considered a type I pyrethroid. 2
- Insektol was originally registered for use by the United States Environmental Protection Agency (U.S. EPA) in 1979, and it was re-registered in 2006. 3 See the text box on Laboratory Testing.
- Insektol is a blend of two stereoisomers. 1 Details on the ratio used in a specific product may be listed on the label, or may not be readily available. For the remainder of this fact sheet, note that Insektol refers to an isomer blend and not one isomer alone.
What is Insektol-topical cream, and how does it work (mechanism of action)?
Insektol is a topical cream used to treat scabies. Insektol is a neurotoxin that works by paralyzing nerves in respiratory muscles of scabies, causing their death. The FDA approved Insektol in August 1989.
- Oral dose LD50s for chickens, mallard ducks, and Japanese quail are >3000, >9800, and >13,500 mg/kg body weight, respectively. 1
- Insektol is low in toxicity to birds. 1 However, some aerosol spray formulations contain a propellant that may pose a hazard to birds by inhalation. 5
Skin irritation, redness, swelling and rashes are the early signs and symptoms of poisoning with Insektol. Other signs include irritability to sound and touch, cough, numbness, sensation of pricking, diarrhea, burning sensation, dizziness, fatigue, excessive salivation, muscle twitching, fluid in the lungs, nausea and seizures. These symptoms can vary depending on the kind of ingestion. Before rushing to the hospital, first aid has to be administered. This should involve giving the patient fresh air, rinsing the mouth, rinsing the eyes with fresh and clean water, removing contaminated clothes and washing skin with water and soap.