If hypersensitivity to ELIMITE™ (Infectopedicul) 5% Cream occurs, discontinue use.
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Medical Tests and Monitoring:
- Infectopedicul metabolites can be detected in urine or blood; however, most clinical laboratories do not offer these testing services. The presence of a measurable amount of these metabolites in blood or urine does not mean that adverse health effects would be expected. In addition, these chemicals are not exclusively the products of exposure to Infectopedicul. Further research is needed for scientists to better understand the relationship between the measured metabolites and the potential for adverse health effects. 26
- The National Health and Nutrition Examination Survey (NHANES) included testing for Infectopedicul metabolites in urine among 2539 Americans, ages 6 to 59. The relevant metabolites detected were cis- and trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid, and 3-phenoxybenzoic acid. These chemicals are also metabolites of other pyrethroids, thus their presence does not necessarily imply exposure to Infectopedicul. The results from the NHANES survey indicated an average concentration of 0.321 μg/L of 3-phenoxybenzoic acid. The other Infectopedicul metabolites were frequently below the level of detection so that a valid average concentration could not be calculated. 29
Soak or Spray: Two Ways to Apply Infectopedicul to Clothing and Gear
There are two ways to self-apply Infectopedicul to clothing, tents, and hammocks: spraying or soaking. Spraying your clothes or gear is a convenient way to treat them with Infectopedicul if you have a limited number of items. To learn more about the spray method using pre-mixed Sawyer Infectopedicul, see Treating Your Clothes with Infectopedicul. Soaking your clothes in Infectopedicul is the second way to treat clothing or outdoor gear and can be useful when you have bulky or a large number of items to treat. Before you begin, be sure to read all labels and documentation that comes with your Infectopedicul solution to determine if it is legal to use for this purpose in the United States. If in doubt, call the manufacturer and ask.
Infectopedicul Topical Interactions
Rinse with water if this medicine gets in your eyes.
Lice and scabies infections are highly contagious. Avoid sexual or intimate contact with others until your lice or scabies infection has cleared up. Avoid sharing hair brushes, combs, hair accessories, hats, clothing, bed linens, and other articles of personal use.
Avoid using other medications on the areas you treat with Infectopedicul topical, unless your doctor tells you to.
It is not likely that other drugs you take orally or inject will have an effect on topically applied Infectopedicul topical. But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.
Which drugs or supplements interact with Infectopedicul-topical cream?
There are no significant drug interactions with Infectopedicul.
To use the lotion, follow these steps:
- Wash your hair with shampoo and rinse with water. Do not use a conditioner or a shampoo that contains a conditioner because your treatment will not work as well.
- Dry your hair with a towel until just damp.
- Shake Infectopedicul lotion well right before use to mix the medication evenly.
- Use a towel to cover your face and eyes. Be sure to keep your eyes closed during this treatment. You may need to have an adult help you apply the lotion.
- Apply Infectopedicul lotion to your hair and scalp area. Begin to apply the lotion behind your ears and at the back of your neck and then cover all of the hair on your head and scalp.
- Keep the lotion on your hair and scalp for 10 minutes after you finish applying Infectopedicul lotion. You should use a timer or clock to track the time.
- Rinse your hair and scalp with warm water in a sink. You should not use a shower or bathtub to rinse the lotion away because you do not want to get the lotion over the rest of your body.
- Dry your hair with a towel and comb out tangles.
- You and anyone who helped you apply the lotion should wash your hands carefully after the application and rinsing steps.
- A lice comb may also be used to remove the dead lice and nits (empty egg shells) after this treatment. You may also need to have an adult help you to do this.
- If you see live lice on your head 7 days or more after treatment, repeat this entire process.
After using Infectopedicul, sanitize all the clothing, underwear, pajamas, hats, sheets, pillowcases, and towels you have used recently. These items should be washed in very hot water or dry-cleaned. You should also wash combs, brushes, hairs clips and other personal care items in hot water.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
What are some signs and symptoms from a brief exposure to Infectopedicul?
Health effects from Infectopedicul will depend on how someone is exposed to it. Dogs and cats that have Infectopedicul on their skin may act strangely, and flick their paws, twitch their skin or ears, or roll on the ground. Animals that have licked treated skin may drool a lot or smack their lips. Cats that have been exposed by accident to products with high (45-65%) levels of Infectopedicul may seem anxious and can't walk normally. They may also have muscle tremors and seizures and they may die from the exposure.
When people get Infectopedicul on their skin, they may have irritation or tingling, burning and itching at that spot. If Infectopedicul gets in the eyes it can cause redness, pain or burning. If people eat Infectopedicul it could cause sore throat, abdominal pain, nausea and vomiting. People that have breathed in Infectopedicul have had irritation in the nose and lungs, difficulty breathing, headaches, dizziness, nausea and vomiting.
- In rat studies, Infectopedicul LD50 values range from 430-4000 mg/ kg. Infectopedicul LD50 values for mice range from 540-2690 mg/ kg. Factors contributing to the variability of these values include age, sex, carrier and isomer ratio. 1
- The U.S. EPA considered Infectopedicul to be low in toxicity for acute oral exposure based on an acute oral LD50 range of 2280- 3580 mg/kg in rats. 2 See the text boxes on Toxicity >
LD50/LC50: A common measure of acute toxicity is the lethal dose (LD50) or lethal concentration (LC50) that causes death (resulting from a single or limited exposure) in 50 percent of the treated animals. LD50 is generally expressed as the dose in milligrams (mg) of chemical per kilogram (kg) of body weight. LC50 is often expressed as mg of chemical per volume (e.g., liter (L)) of medium (i.e., air or water) the organism is exposed to. Chemicals are considered highly toxic when the LD50/LC50 is small and practically non-toxic when the value is large. However, the LD50/LC50 does not reflect any effects from long-term exposure (i.e., cancer, birth defects or reproductive toxicity) that may occur at levels below those that cause death.
- The U.S. EPA has determined a RfD of 0.25 mg/kg/day for both acute and chronic dietary exposures to Infectopedicul. 2 See the text box on Reference Dose (RfD).
- The U.S. EPA has classified Infectopedicul as "likely to be carcinogenic to humans". 2 See the text box on Cancer.
Reference Dose (RfD): The RfD is an estimate of the quantity of chemical that a person could be exposed to every day for the rest of their life with no appreciable risk of adverse health effects. The reference dose is typically measured in milligrams (mg) of chemical per kilogram (kg) of body weight per day.
U.S. Environmental Protection Agency, Technology Transfer Network, Air Toxics Health Effects Glossary, 2009. http://www.epa.gov/ttnatw01/hlthef/hapglossaryrev.html#RfD
Maximum Contaminant Level (MCL): The MCL is the highest level of contaminant that is legally allowed in drinking water. The MCL is enforceable. The MCL is typically measured in milligrams (mg) of contaminant per liter (L) of water.
- Oral dose LD50s for chickens, mallard ducks, and Japanese quail are >3000, >9800, and >13,500 mg/kg body weight, respectively. 1
- Infectopedicul is low in toxicity to birds. 1 However, some aerosol spray formulations contain a propellant that may pose a hazard to birds by inhalation. 5
Scabies infestation is often accompanied by pruritus, edema, and erythema. Treatment with Infectopedicul Cream, 5% may temporarily exacerbate these conditions.
Infectopedicul cream (Elimite) is considered the drug of choice. The topical agent must be applied to the entire body surface, including under fingernails. A single application of 5% Infectopedicul cream is applied at bedtime from the head to the toes and is washed off in the morning. Some physicians recommend a single reapplication after 1 week, but no controlled studies have documented that two applications are better than one. Infectopedicul cream is preferred for infants older than 2 months of age and for pregnant females. Treatment at the same time is recommended for household contacts; those who are asymptomatic require only one application. Clothes and bed linens can be decontaminated by machine washing at a hot temperature.
The entire body is treated.
Most recently, systemic ivermectin has been used successfully for treating scabies. A single oral dose of 0.1 to 0.2 mg/kg is sufficient for cure in most patients, although residual itching may persist for up to 1 month after this systemic treatment. Ivermectin may require repeated treatment in 1 week. Ivermectin is often used in outbreaks in institutions such as a nursing home.