Hexadreson tablets


  • Active Ingredient: Dexamethasone
  • 1 mg, 0.5 mg
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What is Hexadreson?

The active ingredient of Hexadreson brand is dexamethasone. Dexamethasone is a steroid that prevents the release of substances in the body that cause inflammation.

Used for

Hexadreson is used to treat diseases such as: Addison's Disease, Adrenal Insufficiency, Adrenocortical Insufficiency, Adrenogenital Syndrome, Allergic Rhinitis, Ankylosing Spondylitis, Aphthous Ulcer, Aspiration Pneumonia, Asthma, Asthma, acute, Atopic Dermatitis, Bronchopulmonary Dysplasia, Bursitis, Cerebral Edema, Chorioretinitis, Croup, Cushing's Syndrome, Dermatitis Herpetiformis, Eczema, Epicondylitis, Tennis Elbow, Erythroblastopenia, Evan's Syndrome, Gouty Arthritis, Hemolytic Anemia, Hypercalcemia of Malignancy, Idiopathic Thrombocytopenic Purpura, Inflammatory Bowel Disease, Inflammatory Conditions, Iridocyclitis, Iritis, Juvenile Rheumatoid Arthritis, Keratitis, Leukemia, Loeffler's Syndrome, Lymphoma, Meningitis, Haemophilus influenzae, Meningitis, Listeriosis, Meningitis, Meningococcal, Meningitis, Pneumococcal, Mountain Sickness / Altitude Sickness, Multiple Myeloma, Multiple Sclerosis, Mycosis Fungoides, Nausea/Vomiting, Chemotherapy Induced, Neurosarcoidosis, Pemphigus, Plaque Psoriasis, Psoriasis, Psoriatic Arthritis, Pulmonary Tuberculosis, Rheumatoid Arthritis, Sarcoidosis, Seborrheic Dermatitis, Shock, Synovitis, Systemic Lupus Erythematosus, Thrombocytopenia, Toxic Epidermal Necrolysis, Transverse Myelitis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Posterior.

Side Effect

Possible side effects of Hexadreson include: skin rash; backache; acne; increased thirst; pounding in the ears.

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Hexadreson Tablets 0.5, 0.75, 1, 1.5, 2, 4 and 6 mg USP, Hexadreson Oral Solution, 0.5 mg per 5 mL and Hexadreson Intensol ™ Oral Solution (Concentrate), 1 mg per mL are for oral administration.

Each tablet contains:

Hexadreson . . . . . . . . . . . . . . . . . . . .0.5, 0.75, 1, 1.5, 2, 4, or 6 mg

Each 5 mL of Oral Solution contains:

Hexadreson . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .0.5 mg

Each mL of Intensol ™ Oral Solution (Concentrate) contains:

Hexadreson . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1 mg Alcohol30%

Other uses for this medicine

Hexadreson injection is also sometimes used to treat nausea and vomiting from certain types of chemotherapy for cancer and to prevent organ transplant rejection. Talk to your doctor about the risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

HIV drugs

Taking certain drugs used to treat HIV with Hexadreson can reduce the levels of these drugs in your body. This means they may not work as well, and your body may stop responding to your HIV medications. Your doctor may avoid use of these drugs with Hexadreson. Examples of these drugs include:

  • protease inhibitors, such as:
    • atazanavir
    • darunavir
    • fosamprenavir
    • indinavir
    • nelfinavir
    • ritonavir
    • saquinavir
    • simeprevir
    • tipranavir
  • etravirine
  • maraviroc
  • elvitegravir
  • What happens if I overdose?

    Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

    An overdose of Hexadreson is not expected to produce life threatening symptoms. Long term use of high doses can lead to thinning skin, easy bruising, changes in body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.


    Hexadreson Tablets USP:

    0.5 mg yellow, scored tablets (Identified 54 299).

    NDC 0054-8179-25: Unit dose, 10 tablets per strip, 10 strips per shelf pack, 10 shelf packs per shipper. NDC 0054-4179-25: Bottles of 100 tablets.

    0.75 mg pale blue, scored tablet (Identified 54 960).

    NDC 0054-8180-25: Unit dose, 10 tablets per strip, 10 strips per shelf pack, 10 shelf packs per shipper. NDC 0054-4180-25: Bottles of 100 tablets.

    1 mg yellow, scored tablets (Identified 54 489).

    NDC 0054-8174-25: Unit dose, 10 tablets per strip, 10 strips per shelf pack, 10 shelf packs per shipper. NDC 0054-4181-25: Bottles of 100 tablets.

    1.5 mg pink, scored tablets (Identified 54 943).

    NDC 0054-8181-25: Unit dose, 10 tablets per strip, 10 strips per shelf pack, 10 shelf packs per shipper. NDC 0054-4182-25: Bottles of 100 tablets. NDC 0054-4182-31: Bottles of 1000 tablets.

    2 mg white, scored tablets (Identified 54 662).

    NDC 0054-8176-25: Unit dose, 10 tablets per strip, 10 strips per shelf pack, 10 shelf packs per shipper. NDC 0054-4183-25Bottles of 100 tablets.

    4 mg green, scored tablets (Identified 54 892).

    NDC 0054-8175-25: Unit dose, 10 tablets per strip, 10 strips per shelf pack, 10 shelf packs per shipper. NDC 0054-4184-25: Bottles of 100 tablets.

    6 mg aqua, scored tablets (Identified 54 769).

    NDC 0054-8183-25: Unit dose, 10 tablets per strip, 10 strips per shelf pack, 10 shelf packs per shipper. NDC 0054-4186-25:Bottles of 100 tablets.

    Store and Dispense

    Store at 20° to 25°C (68° to 77°F) . Protect from moisture. Dispense in a well-closed, light-resistant container as defined in the USP/NF.

    Hexadreson Oral Solution, 0.5 mg per 5 mL:

    NDC 0054-3177-57: Bottles of 240 mL. NDC 0054-3177-63: Bottles of 500 mL.

    Store and Dispense

    Store at 20° to 25°C (68° to 77°F) . Dispense in a tight, light-resistant container as defined in the USP/NF.

    Hexadreson Intensol ™ Oral Solution (Con-centrate), 1 mg per mL:

    NDC 0054-3176-44: Bottles of 30 mL with calibrated dropper .

    Store and Dispense

    Store at 20° to 25°C (68° to 77°F) . Do not freeze. Do not use if solution contains a precipitate. Dispense only in this bottle and only with the calibrated dropper provided. Discard opened bottle after 90 days.

    Boehringer Ingelheim, Roxane laboratories. Revised September 2007. FDA revision date: 08/28/96

    3. Hexadreson

    Hexadreson provides significant relief from inflammation-based pain in chronic adjuvant-induced arthritis ( Colpaert et al., 2001 ; Wilson et al., 2006 ). It also allows for a return of normal mobility in arthritic rats ( Matson et al., 2007 ) and improves the clinical condition of aged, adrenalectomized arthritic rats ( Yokoro et al., 2003 ). Hexadreson does not provide analgesia in rodents with mechanical, neuropathic, and thermal pain ( Veiga et al., 2004 ). While effective in increasing the threshold for pressure pain in endotoxin-induced hyperalgesia, Hexadreson is only marginally effective or ineffective in alleviating thermal pain associated with this model ( Kanaan et al., 1997 ). Thus, the type of model will determine the potential usefulness of Hexadreson.

    Epilepsy drugs

    When used with Hexadreson, certain drugs used to treat epilepsy can lower the level of Hexadreson in your blood. This can keep Hexadreson from working well. Examples of these drugs include:

    • phenytoin
    • fosphenytoin
    • phenobarbital
    • carbamazepine

    • Heart Damage Warning: If you’ve recently had a heart attack, you may be at increased risk for further heart damage from this drug. Before starting this drug, be sure your doctor knows you’ve had a heart attack.
    • Infection Warning: Hexadreson can cover up or worsen certain infections. In addition, infections can develop during treatment. Don’t use this drug if you have fungal infections, or a history of parasite infections or tuberculosis. Tell your doctor about any past illnesses or infections.
    • Eye Problems Warning: Using Hexadreson for long periods can lead to eye problems such as cataracts or glaucoma. The drug may also cause damage to the optic nerves, or fungal or viral eye infections.
    • Measles or Chickenpox Warning: Tell your doctor if you haven’t had chickenpox or measles, or if you haven’t had the vaccines to prevent them. You could have more serious versions of these illnesses if you have them while taking Hexadreson.

    Hexadreson is a prescription medication. It’s available as an oral tablet, oral solution, eye drops, and eardrops. It’s also available as an injectable solution or an intraocular solution given after surgery. These last two forms are only given by a healthcare provider.

    The Hexadreson tablet is available as the brand-name drug DexPak. It’s also available as a generic drug. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in all strengths or forms as the brand-name drug.

    Why it's used

    The Hexadreson oral tablet is used to treat conditions that cause inflammation, conditions related to immune system activity, and hormone deficiency. These conditions include:

    • inflammation
    • allergic reactions
    • rheumatoid arthritis and other rheumatic diseases, including ankylosing spondylitis, psoriatic arthritis, juvenile rheumatoid arthritis, lupus, and acute gouty arthritis
    • skin diseases, such as pemphigus, severe erythema multiforme (Stevens-Johnson syndrome), exfoliative dermatitis, bullous dermatitis herpetiformis, severe seborrheic dermatitis, severe psoriasis, or mycosis fungoides
    • flare-ups of intestinal disease, such as ulcerative colitis
    • flare-ups of multiple sclerosis or myasthenia gravis
    • pre-treatment for chemotherapy to reduce inflammation and side effects from cancer medications
    • adrenal insufficiency (a condition where the adrenal glands don’t produce enough hormones)

    What should I do if I forget a dose?

    When you start to take Hexadreson, ask your doctor what to do if you forget a dose. Write down these instructions so that you can refer to them later.

    If you take Hexadreson once a day, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.


    Hexadreson can cause a severe allergic reaction. Symptoms can include:

    • trouble breathing
    • swelling of your throat or tongue

    If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 911 or go to the nearest emergency room.

    Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

    Hexadreson may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • upset stomach
    • stomach irritation
    • vomiting
    • headache
    • dizziness
    • insomnia
    • restlessness
    • depression
    • anxiety
    • acne
    • increased hair growth
    • easy bruising
    • irregular or absent menstrual periods

    Diuretics (water pills)

    When used with Hexadreson, these drugs reduce your body’s potassium levels. (Potassium is a mineral that helps your nerves, muscles, and organs work normally.) This can cause muscle cramps, weakness, tiredness, and an irregular heartbeat. Examples of these drugs include:

    • bumetanide
    • furosemide
    • hydrochlorothiazide

    For the treatment of Primary Hyperaldosteronism purchase Noidouble online tablets

    What should I discuss with my healthcare provider before taking Hexadreson?

    You should not use Hexadreson if you are allergic to it, or if you have:

    • a fungal infection anywhere in your body.

    Tell your doctor if you have ever had:

    Steroid medication affects your immune system. You may get infections more easily. Steroids can also worsen or reactivate an infection you've already had. Tell your doctor about any illness or infection you have had within the past several weeks.

    It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.

    You should not breast-feed while using Hexadreson.

    2.2.1 Administration of Hexadreson

    Hexadreson is a synthetic corticosteroid analogue of the steroid hormone cortisol. Large quantities (eg, 0.5 mg/kg) of corticosteroids exogenously administered to an animal cause non-specific immunosuppression ( Plumb, 2005 ). Administration of Hexadreson to Merino sheep which were genetically resistant to gastrointestinal nematode (GIN) infection demonstrated that immunity to both primary and challenge H. contortus infections was decreased, implicating both innate and adaptive immunity, respectively ( Adams, 1988; Presson et al., 1988 ). Hexadreson administration also abrogated immune protection in sheep which had been rendered immune by prior repeated larval challenges for 10–12 weeks ( Huntley et al., 1992 ). Another study demonstrated that pasture-raised Gulf Coast Native lambs, a breed considered to have natural immunity to H. contortus infection, had significantly higher faecal egg counts (FECs) and adult worm counts than untreated sheep when treated with Hexadreson ( Pena et al., 2004 ). These early studies on the abrogation of protection against GINs by using Hexadreson strongly suggested that immunity was an integral part of the protective response against H. contortus infection; however, the basis for this immunity was unknown at the time.

    Serious side effects

    Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

    • Unusual tiredness
    • Unusual dizziness
    • stomach pain
    • nausea or vomiting
  • Blood in your stool, or black stools
  • Blood in your urine
  • Unusual bleeding or bruising
  • Unusual swelling throughout your body, or bloating in your abdomen (stomach area)
  • fever
  • muscle aches
  • joint pain
  • severe mood swings
  • euphoria (a feeling of intense happiness)
  • trouble sleeping
  • personality changes
  • fever
  • trouble breathing
  • tiredness
  • nausea
  • darkened skin color
  • dizziness when standing
  • More frequent infections (can occur with long-term use)
  • pain in the abdomen (stomach area)
  • shortness of breath
  • tiredness
  • swollen legs
  • rapid heartbeat
  • Osteoporosis (thinning of the bones)
  • Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

    Hexadreson oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

    To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

    Examples of drugs that can cause interactions with Hexadreson are listed below.

    Tuberculosis drugs

    When used with Hexadreson, certain drugs used to treat tuberculosis (TB) can lower the level of Hexadreson in your blood. This can keep Hexadreson from working well. Examples of these drugs include:

    Isoniazid is another TB drug. When it’s used with Hexadreson, levels of isoniazid can be lowered. This can keep isoniazid from working well.

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