Gentadex tablets

Gentadex

  • Active Ingredient: Dexamethasone
  • 1 mg, 0.5 mg
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What is Gentadex?

The active ingredient of Gentadex brand is dexamethasone. Dexamethasone is a steroid that prevents the release of substances in the body that cause inflammation.

Used for

Gentadex is used to treat diseases such as: Addison's Disease, Adrenal Insufficiency, Adrenocortical Insufficiency, Adrenogenital Syndrome, Allergic Rhinitis, Ankylosing Spondylitis, Aphthous Ulcer, Aspiration Pneumonia, Asthma, Asthma, acute, Atopic Dermatitis, Bronchopulmonary Dysplasia, Bursitis, Cerebral Edema, Chorioretinitis, Croup, Cushing's Syndrome, Dermatitis Herpetiformis, Eczema, Epicondylitis, Tennis Elbow, Erythroblastopenia, Evan's Syndrome, Gouty Arthritis, Hemolytic Anemia, Hypercalcemia of Malignancy, Idiopathic Thrombocytopenic Purpura, Inflammatory Bowel Disease, Inflammatory Conditions, Iridocyclitis, Iritis, Juvenile Rheumatoid Arthritis, Keratitis, Leukemia, Loeffler's Syndrome, Lymphoma, Meningitis, Haemophilus influenzae, Meningitis, Listeriosis, Meningitis, Meningococcal, Meningitis, Pneumococcal, Mountain Sickness / Altitude Sickness, Multiple Myeloma, Multiple Sclerosis, Mycosis Fungoides, Nausea/Vomiting, Chemotherapy Induced, Neurosarcoidosis, Pemphigus, Plaque Psoriasis, Psoriasis, Psoriatic Arthritis, Pulmonary Tuberculosis, Rheumatoid Arthritis, Sarcoidosis, Seborrheic Dermatitis, Shock, Synovitis, Systemic Lupus Erythematosus, Thrombocytopenia, Toxic Epidermal Necrolysis, Transverse Myelitis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Posterior.

Side Effect

Possible side effects of Gentadex include: Aggression; darkening of skin; irritability; fatigue; numbness or tingling in the arms or legs.

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How to use Gentadex

Take this medication by mouth as directed by your doctor. Take with food or milk to prevent stomach upset. Take this medication by mouth with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise. If you are using the liquid form of the medication, use a medication-measuring device to carefully measure the prescribed dose. Do not use a household spoon.

If you take this medication once daily, take it in the morning before 9 AM. If you are taking this medication every other day or on another schedule besides a daily one, it may help to mark your calendar with a reminder.

The dosage and length of treatment are based on your medical condition and response to therapy. Your doctor may attempt to reduce your dose slowly from time to time to minimize side effects.

Use this medication regularly in order to get the most benefit from it. To help you remember, take it at the same time(s) each day. It is important to continue taking this medication even if you feel well. Follow the dosing schedule carefully, and take this medication exactly as prescribed.

Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Your dose may need to be gradually decreased.

Inform your doctor if your condition does not improve or worsens.

Before taking Gentadex

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking Gentadex it is important that your doctor knows:

  • If you have high blood pressure (hypertension).
  • If you have had a heart attack, or if you have any other heart problems.
  • If you have any problems with the way your liver works, or if you have any problems with the way your k >

Vaccines

Avoid getting vaccines when taking Gentadex. Certain vaccines may not work as well for people taking this drug. Also, the drug may make some live vaccines stronger. This raises the risk of side effects from the vaccine.

What is Gentadex?

Gentadex is a corticosteroid that prevents the release of substances in the body that cause inflammation.

Gentadex is used to treat many different inflammatory conditions such as allergic disorders and skin conditions.

Gentadex is also used to treat ulcerative colitis, arthritis, lupus, psoriasis, and breathing disorders.

Gentadex may also be used for purposes not listed in this medication guide.

Common Side Effects of Gentadex

Increased appetite is one of the commonly reported side effects of Gentadex.

Unless it persists or is bothering you, it does not warrant medical attention. Your appetite may return to normal again once your body adjusts to the medicine.

Other s >Gentadex include:

  • Acne
  • Dry scalp
  • Hair thinning
  • Reddish face, lightening of skin
  • Swelling in the abdominal area
  • Weight gain
  • Insomnia

Antifungal drugs

When used with Gentadex, certain drugs used to treat fungal infections can increase the level of Gentadex in your blood. This can raise your risk of side effects. Examples of these drugs include:

  • ketoconazole
  • itraconazole
  • posaconazole
  • voriconazole

Amphotericin B is another drug used to treat fungal infections. Using this drug with Gentadex raises your risk of low potassium levels. (Potassium is a mineral that helps your nerves, muscles, and organs work normally.) This can cause muscle cramps, weakness, tiredness, and an irregular heartbeat.

Antibiotics

Erythromycin is used to treat infections caused by bacteria. When used with Gentadex, this drug can increase the amount of Gentadex in your body. This raises your risk of side effects.

Precautions

Before taking Gentadex, tell your doctor or pharmacist if you are allergic to it; or to other corticosteroids (e.g., prednisone); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: infections (e.g., tuberculosis, herpes, fungal infections), kidney disease, liver disease, mental/mood conditions (e.g., psychosis, anxiety, depression), low blood minerals (e.g., low potassium/calcium), thyroid disease, stomach/intestinal problems (e.g., ulcer, ulcerative colitis, diverticulitis, unexplained diarrhea), high blood pressure, heart problems (e.g., congestive heart failure, recent heart attack), diabetes, eye diseases (e.g., cataracts, glaucoma, herpes infection of the eye), brittle bones (osteoporosis), history of blood clots.

This medication may mask signs of infection or put you at greater risk of developing very serious infections. Report any injuries or signs of infection (e.g., persistent sore throat/fever/cough, pain during urination, muscle aches) that occur during treatment.

Using corticosteroid medications for a long time can make it more difficult for your body to respond to physical stress. Therefore, before having surgery or emergency treatment, or if you get a serious illness/injury, tell your doctor or dentist that you are using this medication or have used this medication within the past 12 months. Tell your doctor right away if you develop unusual/extreme tiredness or weight loss. If you will be using this medication for a long time, carry a warning card or medical ID bracelet that identifies your use of this medication.

Do not have immunizations, vaccinations, or skin tests unless specifically directed by your doctor. Live vaccines may cause serious complications (e.g., infection) if given while you are taking this medication. Avoid contact with people who have recently received oral polio vaccine or flu vaccine inhaled through the nose.

Avoid contact with people who have chickenpox or measles unless you have previously had these diseases (e.g., in childhood). If you are exposed to one of these infections and you have not previously had it, seek immediate medical attention.

If you have a history of ulcers or take large doses of aspirin or other arthritis medication, limit alcoholic beverages while taking this medication to decrease the risk of stomach/intestinal bleeding. Consult your doctor or pharmacist for more details.

If you have diabetes, this drug may make it harder to control your blood sugar levels. Monitor your blood sugar levels regularly and inform your doctor of the results. Your medicine, exercise plan, or diet may need to be adjusted.

This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

This medication may slow down a child's growth if used for a long time. Consult the doctor or pharmacist for more details. See the doctor regularly so your child's height and growth can be checked.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. Infants born to mothers who have been using this medication for an extended time and/or at high doses may have low levels of corticosteroid hormone. Tell your doctor right away if you notice symptoms such as persistent nausea/vomiting, severe diarrhea, or weakness in your newborn.

This drug may pass into breast milk and could have undesirable effects on a nursing infant. Consult your doctor before breast- feeding.

Gentadex for Dogs and Cats

Veterinarians prescribe Gentadex for dogs and cats when they need to treat immune system problems such as asthma, hives, itching, inflammation, and skin and eye problems.

Intravenous (IV) Gentadex is approved for use in cattle and horses.

What is the dosage for Gentadex?

Dosage requirements of corticosteroids vary greatly among individuals and the diseases being treated. In general, the lowest possible effective dose is used. The initial oral dose is 0.75 mg to 9 mg daily depending on the disease. The initial dose should be adjusted based on response. Corticosteroids given in multiple doses (2 to 4 times daily) throughout the day are more effective but also are more toxic as compared with the same total daily dose given once daily, or every other day.

Important Information

You should not use Gentadex if you have a fungal infection anywhere in your body.

Tell your doctor about all your medical conditions, and all the medicines you are using. There are many other diseases that can be affected by steroid use, and many other medicines that can interact with steroids.

Your dosage may change if you have any unusual stress such as a serious illness, fever or infection, or if you have surgery or a medical emergency. Tell your doctor about any such situation that affects you during treatment.

Gentadex can weaken your immune system, making it easier for you to get an infection or worsening an infection you already have or have recently had. Tell your doctor about any illness or infection you have had within the past several weeks.

Call your doctor for preventive treatment if you are exposed to chicken pox or measles. These conditions can be serious or even fatal in people who are using steroid medication.

All vaccines may not work as well while you are taking a steroid. Do not receive a "live" vaccine while you are taking this medicine.

Do not stop using Gentadex suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication.

Important: you should let your doctor know if you start to experience blurred vision or other vision problems whilst taking Gentadex.

For more information about side-effects which are possible when Gentadex is taken long-term, see the separate leaflet called Oral Steroids.

Which drugs or supplements interact with Gentadex?

Corticosteroids may increase or decrease the effect of blood thinners, for example, warfarin (Coumadin). Blood clotting should be monitored and the dose of blood thinner adjusted in order to achieve the desired level of blood thinning when patients receiving blood thinners are begun on corticosteroids, including Gentadex.

Phenobarbital, ephedrine, phenytoin (Dilantin), and rifampin (Rifadin, Rimactane) may increase the breakdown of corticosteroids by the liver, resulting in lower blood levels and reduced effects. Therefore, the dose of corticosteroid may need to be increased if treatment with any of these agents is begun.

Mifepristone may reduce the action of corticosteroids via unknown mechanisms. Gentadex may decrease blood levels of mifepristone. Mifepristone should not be combined with steroids.

Gentadex sodium phosphate

Pharmacologic class: Glucocorticoid

Therapeutic class: Anti-inflammatory

Pregnancy risk category C

Tuberculosis drugs

When used with Gentadex, certain drugs used to treat tuberculosis (TB) can lower the level of Gentadex in your blood. This can keep Gentadex from working well. Examples of these drugs include:

Isoniazid is another TB drug. When it’s used with Gentadex, levels of isoniazid can be lowered. This can keep isoniazid from working well.


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