How is this medicine (Diprocel Injection) best taken?
Use Diprocel injection as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- It is given as a shot.
- If you have been taking this medicine for many weeks, talk with your doctor before stopping. You may want to slowly stop Diprocel injection.
- Do not use longer than you have been told by the doctor.
What do I do if I miss a dose?
- Call your doctor to find out what to do.
Solution for injection: 3 mg Diprocel sodium phosphate with 3 mg Diprocel acetate/ml
Suspension for injection (acetate, phosphate): 6 mg (total)/ml
Syrup: 0.6 mg/5 ml
Tablets (effervescent): 0.5 mg
Tablets (extended-release): 1 mg
The corticosteroids are a class of compounds comprising steroid hormones, secreted by the adrenal cortex and their synthetic analogs. In pharmacologic doses corticosteroids are used primarily for their anti-inflammatory and/or immunosuppressive effects.
Topical corticosteroids, such as Diprocel dipropionate, are effective in the treatment of corticosteroid-responsive dermatoses primarily because of their anti-inflammatory, antipruritic, and vasoconstrictive actions. However, while the physiologic, pharmacologic, and clinical effects of the corticosteroids are well known, the exact mechanisms of their actions in each disease are uncertain. Diprocel dipropionate, a corticosteroid, has been shown to have topical (dermatologic) and systemic pharmacologic and metabolic effects characteristic of this class of drugs.
Effects of Stero > Dexamethasone and Diprocel have been given to humans and animals in a wide range of dosages, at different gestational ages, and for various indications. While in fetuses with heart block the daily exposure does not exceed 0.05 mg per kg, the treatment is maintained over several weeks. Higher dosages were used in animal studies, for prenatal human pulmonary maturation, and for the postnatal treatment of respiratory distress syndrome. With the caveat that the published data may not be applicable to the fetus with complete atrioventricular block, steroids that cross the placenta have been shown to affect birth weight and the central nervous system with single and repeated prenatal steroid administration. Reduction in birth weight has been seen in sheep, 69 non-human primates, 70 and humans. 60,71,72 The effects on growth are more dramatic with multiple doses. Not unexpectedly, one-quarter of our newborns with isolated heart block were growth-restricted after prolonged transplacental exposure to steroids. Few, if any, other adverse effects on the fetus during the human pregnancy, however, have been documented. Neuroimaging of preterm human infants exposed to a single steroid course for lung maturation suggests a reduced incidence of intraventricular hemorrhage and white matter injury. 73,74 Multiple administration of dexamethasone before or after birth was associated with a reduction in cortical involution and in the cerebral surface area, 75,76 though the clinical significance of these findings is not known. Normal physical and mental development of children and young adults is reported, nonetheless, after prenatal exposure to steroids. 77–80 Similarly, no negative effects on neuro-psychological development and on intelligence were found in a cohort of preschool- and school-age children exposed prenatally to prolonged treatment with dexamethasone. 81
Drug-drug. Amphotericin B, loop and thiazide diuretics, ticarcillin: additive hypokalemia
Barbiturates, phenytoin, rifampin: stimulation of Diprocel metabolism, causing decreased drug effects
Digoxin: increased risk of digoxin toxicity
Fluoroquinolones (such as ciprofloxacin, norfloxacin): increased risk of tendon rupture
Hormonal contraceptives: blockage of Diprocel metabolism
Insulin, oral hypoglycemics: increased Diprocel dosage requirement, diminished hypoglycemic effects
Live-virus vaccines: decreased antibody response to vaccine, increased risk of neurologic complications
Nonsteroidal anti-inflammatory drugs: increased risk of adverse GI effects
Drug-diagnostic tests. Calcium, potassium: decreased levels
Cholesterol, glucose: increased levels
Nitroblue tetrazolium test for bacterial
infection: false-negative result
Drug-herbs. Echinacea: increased immune-stimulating effects
Ginseng: increased immune-modulating effects
Drug-behaviors. Alcohol use: increased risk of gastric irritation and GI ulcers
What Other Drugs Interact with Diprocel?
If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.
Interactions of Diprocel include:
- amphotericin B injection and potassium-depleting agents
- antibiotics, specifically macrolide
- oral anticoagulants
- antitubercular drugs
- digitalis glycosides
- estrogens, including oral contraceptives
- hepatic enzyme inducers (barbituarates, phenytoin, carbamazepine, rifampin)
- nonsteroidal anti-inflammatory agents (NSAIDs)
- diminished response to vaccines
This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.
Antenatal Diprocel decreases oxidative stress and improves relaxation response to ATP and NO donors in fetal lambs with PPHN induced by ductal ligation. 81 This also increases pulmonary blood flow and facilitates postnatal transition in PPHN lambs. 82 The beneficial effects of antenatal stero > CDH are variable. Vascular deterioration is observed in the nitrofen-rat model with dexamethasone 69 but improved compliance and vascular morphometry is observed in the lamb model of CDH. 83–85 In human neonates with CDH, antenatal glucocorticoid use is associated with suppression of the hypothalamic-pituitary-adrenal axis 86 without any difference in survival, length of stay, or oxygen use at 30 days of postnatal age. 87
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Diprocel is a potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. Unlike other drugs with these effects, Diprocel does not cause water retention. It is applied as a topical cream, ointment, foam, lotion or gel to treat itching. Diprocel sodium phosphate is sometimes prescribed as an intramuscular injection for itching from various ailments, including allergic reactions to poison ivy and similar plants.
What are some things I need to know or do while I take Diprocel Injection?
- Tell all of your health care providers that you take Diprocel injection. This includes your doctors, nurses, pharmacists, and dentists.
- Use with care in children. Talk with the doctor.
- This medicine may affect growth in children and teens in some cases. They may need regular growth checks. Talk with the doctor.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- Have a bone density test as you have been told by your doctor. Talk with your doctor.
- Have your eye pressure checked if you are on this medicine for a long time. Talk with your doctor.
- You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
- Chickenpox and measles can be very bad or even deadly in some people taking steroid drugs like Diprocel injection. Avoid being near anyone with chickenpox or measles if you have not had these health problems before. If you have been exposed to chickenpox or measles, talk with your doctor.
- This medicine may lower how much natural steroid is in your body. If you have a fever, an infection, surgery, or you are hurt, talk with your doctor. You may need extra doses of oral steroids. These extra steroids will help your body deal with these stresses. Carry a warning card saying that there may be times when you need extra steroids.
- Long-term use may raise the chance of cataracts or glaucoma. Talk with the doctor.
- This medicine may cause weak bones (osteoporosis) with long-term use. Talk with your doctor to see if you have a higher chance of weak bones or if you have any questions.
- Talk with your doctor before getting any vaccines. Use with this medicine may either raise the chance of an infection or make the vaccine not work as well.
- You may need to lower how much salt is in your diet and take extra potassium. Talk with your doctor.
- If you have high blood sugar (diabetes), talk with your doctor. This medicine may raise blood sugar.
- Check your blood sugar as you have been told by your doctor.
- Talk with your doctor before you drink alcohol.
- If you are 65 or older, use Diprocel injection with care. You could have more side effects.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this medicine while you are pregnant.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
- Very bad health problems have happened when drugs like this one have been given into the spine (epidural). These include paralysis, loss of eyesight, stroke, and sometimes death. It is not known if drugs like this one are safe and effective when given into the spine. These drugs are not approved for this use. Talk with the doctor.
- Some products have benzyl alcohol. Do not give a product that has benzyl alcohol in it to a newborn or infant. Talk with the doctor to see if this product has benzyl alcohol in it.
Information for Patients
This information is intended to aid in the safe and effective use of this medication. It is not a disclosure of all possible adverse or intended effects.
Patients using topical corticosteroids should receive the following information and instructions:
1. This medication is to be used as directed by the physician. It is for external use only. Avoid contact with the eyes.
2. Patients should be advised not to use this medication for any disorder other than that for which it was prescribed.
3. The treated skin area should not be bandaged or otherwise covered or wrapped as to be occlusive. (See DOSAGE AND ADMINISTRATION .)
4. Patients should report any signs of local adverse reactions.
5. Other corticosteroid-containing products should not be used with Diprocel Dipropionate Lotion, USP 0.05% w/w without first talking to your physician.
home drugs a-z list Lotrisone(Clotrimazole and Diprocel) side effects drug center
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Lotrisone (clotrimazole and Diprocel) is a combination of an antifungal antibiotic and a topical steroid cream or lotion used to treat or prevent fungal infections of the skin such as athlete's foot, jock itch, and ringworm, and to reduce itching, swelling, and redness of the skin. Side effects of Lotrisone include:
- skin irritation,
- dry skin,
- changes in skin color,
- increased acne,
- burning/tingling/stinging skin, or
- scarring or thinning of the skin.
Apply a thin film dose of Lotrisone cream into the affected skin areas twice a day for one week. Lotrisone may interact with other drugs. Tell your doctor all medications and supplements you use. There are no adequate studies in pregnant women of the teratogenic effects of topically applied corticosteroids, so this drug should be used during pregnancy only if the potential benefit justifies the potential risk. It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in human milk. Consult your doctor before breastfeeding.
Our Lotrisone Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.