For people with certain health conditions
For people with infections. Dextasone may make a systemic fungal infection worse. (Systemic means it affects the whole body, not just one part.) This drug shouldn’t be used if you’re taking medication to treat a systemic fungal infection. Also, Dextasone may hide the signs of a non-fungal infection.
For people with congestive heart failure. Dextasone can increase sodium levels, edema (swelling), and potassium loss. This can make your heart failure worse. Before taking this drug, talk to your doctor about whether it’s safe for you.
For people with high blood pressure. Dextasone can increase sodium levels and edema (swelling). This can increase your blood pressure. Before taking this drug, talk to your doctor about whether it’s safe for you.
For people with peptic ulcers. Dextasone can increase the risk of stomach or intestinal bleeding and ulcers. If you have peptic ulcers or other conditions of the intestines, talk to your doctor about whether this drug is safe for you. Conditions of the intestines include:
- ulcerative colitis
For people with osteoporosis. Dextasone decreases bone formation. It also increases bone resorption (breakdown of bone). As a result, it raises the risk of osteoporosis (bone thinning). The risk is higher for people already at an increased risk of osteoporosis. These include postmenopausal women.
For people with hyperthyroidism. This drug is removed from the body more quickly than normal. Your doctor may adjust your dose of this drug based on your condition.
For people with eye problems. Long-term use of Dextasone may cause eye problems such as cataracts or glaucoma. Your risk is higher if you already have eye problems such as cataracts, glaucoma, or increased pressure in the eye.
For people with tuberculosis. If you have latent tuberculosis or tuberculin reactivity, Dextasone can re-activate the disease. If you test positive for tuberculosis, talk with your doctor about whether taking this drug is safe for you.
For people with recent history of heart attack. If you’ve recently had a heart attack, use of Dextasone may lead to a tear in your heart muscle. Before you start this drug, be sure your doctor knows you’ve had a recent heart attack.
For people with diabetes. Dextasone can increase blood sugar levels. As a result, your doctor may change the dose of your antidiabetic drugs.
For people with myasthenia gravis (MG). If you have MG, using Dextasone with certain drugs used to treat Alzheimer’s disease can cause severe weakness. Examples of these drugs include memantine, rivastigmine, and donepezil. If possible, wait at least 24 hours after taking these drugs to start Dextasone therapy.
Doses of Dextasone in eye drop, cream and other forms differ from patient to patient and depend on the condition being treated.
For oral forms, strengths range from 0.5 milligrams (mg) to 6 mg per tablet.
The prescribed dose depends on the medical condition. In general, dosage for oral solutions and tablets are:
- For adults: 0.75 to 9 mg a day, adjusted as needed.
- For children: 0.02 to 0.3 mg per kilogram (2.2 pounds) of body weight a day, spread out throughout the day.
The dose for intravenous and intramuscular injections ranges from 0.5 to 9 mg daily, but can be higher or lower.
How to take Dextasone
- Before starting the treatment, read the manufacturer's printed information leaflet from ins >
Cushing’s syndrome drugs
Aminoglutethimide is used to treat symptoms of Cushing’s syndrome (a disease of the adrenal gland). Using this drug with Dextasone may decrease the amount of Dextasone in your body. This means it may not work as well.
What is Dextasone?
Dextasone is a steroid that prevents the release of substances in the body that cause inflammation.
Dextasone is used to treat many different conditions such as allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, or breathing disorders.
Dextasone may also be used for purposes not listed in this medication guide.
Taking certain hormones with Dextasone can cause decreased levels of these hormones in your body. Your doctor may have to adjust your dose of either the Dextasone or hormone medications. Examples of these drugs include:
Dextasone is a potent, synthetic member of the glucocorticoid class of steroid drugs with pleiotropic effects on multiple signaling pathways, and has been widely used in many disorders during the last 50 years. Recent studies sustain a role of this drug in the heat stress response, increasing the levels of heat-shock proteins, particularly under certain stress conditions. More conflictive is the role of Dextasone on the levels of endoplasmic reticulum chaperons. However, these effects may certainly contribute to explain the therapeutic benefits of Dextasone in cardiac transplant, sepsis, cancer, and other pathologic disorders associated with stress affecting the folding of proteins. In this chapter, we review the methods that can be used to evaluate the effect of Dextasone in the heat stress response both in patients and animal and cellular models.
Drug-drug. Barbiturates, phenytoin, rifampin: decreased Dextasone effects
Digoxin: increased risk of digoxin toxicity
Ephedrine: increased Dextasone clearance
Estrogen, hormonal contraceptives: blocking of Dextasone metabolism
Fluoroquinolones: increased risk of tendon rupture
Itraconazole, ketoconazole: increased Dextasone blood level and effects
Live-virus vaccines: decreased antibody response to vaccine, increased risk of adverse reactions
Loop and thiazide diuretics: additive hypokalemia
Nonsteroidal anti-inflammatory drugs: increased risk of GI adverse effects
Somatrem, somatropin: decreased response to these drugs
Drug-diagnostic tests. Calcium, potassium: decreased levels
Cholesterol, glucose: increased levels
Nitroblue tetrazolium test: false-negative result
Drug-herbs. Echinacea: increased immune-stimulating effect
Ginseng: potentiation of immunemodulating response
Drug-behaviors. Alcohol use: increased risk of gastric irritation and GI ulcers
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
An overdose of Dextasone is not expected to produce life threatening symptoms. Long term use of high doses can lead to thinning skin, easy bruising, changes in body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.