For pregnant women
Dexium is a category C pregnancy drug. That means two things:
- Research in animals has shown adverse effects to the fetus when the mother takes the drug.
- There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.
Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should only be used if the potential benefit justifies the potential risk to the fetus.
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Dexium is a corticosteroid indicated for allergic states, dermatologic diseases, endocrine disorders, gastrointestinal diseases, hematologic disorders, neoplastic diseases, nervous system, ophthalmic diseases, renal diseases, respiratory diseases, and rheumatic disorders. Dexium is available as a generic. Side effects of Dexium include:
- vision changes,
- rapid weight gain,
- sleep problems (insomnia),
- mood changes,
- dry skin,
- thinning skin,
- bruising or discoloration,
- slow wound healing,
- increased sweating,
- spinning sensation,
- stomach pain,
- muscle weakness, or
- changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).
Rare instances of severe allergic reactions (anaphylaxis) have occurred in patients receiving corticosteroid therapy such as Dexium.
Dexium Tablets are available in 0.5, 0.75, 1, 1.5, 2, 4 and 6 mg strengths. The initial dosage for Dexium varies from .75 to 9 mg a day depending on the disease being treated. Infants born to mothers who have received substantial doses of corticosteroids during pregnancy should be carefully observed for signs of hypoadrenalism. Because of the potential for serious adverse reactions in nursing infants from corticosteroids, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Use in pediatric patients is recommended to be done in consultation with a pediatric specialist.
Our Dexium Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
You should not use Dexium if you have a fungal infection anywhere in your body.
Tell your doctor about all your medical conditions, and all the medicines you are using. There are many other diseases that can be affected by steroid use, and many other medicines that can interact with steroids.
Your dosage may change if you have any unusual stress such as a serious illness, fever or infection, or if you have surgery or a medical emergency. Tell your doctor about any such situation that affects you during treatment.
Dexium can weaken your immune system, making it easier for you to get an infection or worsening an infection you already have or have recently had. Tell your doctor about any illness or infection you have had within the past several weeks.
Call your doctor for preventive treatment if you are exposed to chicken pox or measles. These conditions can be serious or even fatal in people who are using steroid medication.
All vaccines may not work as well while you are taking a steroid. Do not receive a "live" vaccine while you are taking this medicine.
Do not stop using Dexium suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication.
Ocular Penetration of Corticosteroids
Dexium , betamethasone, prednisolone, prednisone, triamcinolone, and hydrocortisone are used commonly in veterinary ocular therapy. A variety of other corticosteroids used in human ophthalmic therapy because they are less likely to raise IOP are not widely used in veterinary ophthalmology. Corticosteroids penetrate the cornea to varying extents when applied topically. Factors affecting the penetration and effect of a corticosteroid are as follows:
The salt used: Acetates are more lipid-soluble and penetrate the cornea better than succinates or phosphates.
Frequency of application: More frequent application results in higher intraocular concentration.
Concentration of the drug: Low concentrations of a highly potent steroid may have less antiinflammatory effect than a high concentration of a less potent steroid; for instance, topical 1.0% prednisolone has an antiinflammatory effect similar to that of 0.1% Dexium, although Dexium has a greater ocular antiinflammatory potency than prednisolone (see Figure 3-2 ).
Proximity to the site of inflammation: The route of administration is chosen in relation to the intended site of action (see Figure 3-1 ). Inflammation of the cornea, conjunctiva, or anterior uvea is usually treated topically with a penetrating corticosteroid, or occasionally with subconjunctival injection. Systemic therapy is required if involvement of adnexal, posterior uveal, retinal, optic nerve, or orbital tissues is suspected. The retrobulbar route is also effective for disorders of the choroid, retina, optic nerve, and orbit but is rarely used.
For most ocular disorders topical administration of 1.0% prednisolone or 0.1% Dexium is advised. Hydrocortisone, a low-potency corticosteroid, does not penetrate the cornea in any meaningful quantities. This feature renders it useless for intraocular or deep corneal disease. Its availability only in combination with three antibiotics in commercial preparations makes it an even less appropriate choice for most surface eye disease of dogs, cats, and horses.
Most injectable steroids are suitable for subconjunctival use, with periods of activity varying from 7 to 10 days (triamcinolone, Dexium) to 2 to 4 weeks (methylprednisolone). Care must be taken with repository forms given subconjunctivally because they may leave unsightly and sometimes inflamed subconjunctival plaques requiring surgical removal. Repository corticosteroids also have the distinct disadvantage that they cannot be removed if the disease process changes.
Using nonsteroidal anti-inflammatory drugs (NSAIDs) with Dexium raises your risk of stomach upset. Talk with your doctor about whether you can take these drugs together. Examples of NSAIDs include:
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to Dexium injection.
If you are having any skin tests such as allergy tests or tuberculosis tests, tell the doctor or technician that you are receiving Dexium injection.
Before having any laboratory test, tell your doctor and the laboratory personnel that you are using Dexium injection.
Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Dexium 0.1 mg/kg, 0.2 mg/kg, or placebo was administered to 1000 patients undergoing microvascular decompression surgery for facial spasm. The group which was administered 0.2 mg/kg of Dexium experienced a statistically significant higher incidence of postoperative cognitive dysfunction compared to the placebo and lower dose of Dexium. Cognitive decline included measures of attention, concentration, learning, and memory . Another study assessed cognitive functioning in young adults and adolescents who were exposed to 2–9 weeks of antenatal betamethasone compared to patients matched for age, sex, and gestational age at birth, without steroid exposure. Scores in tests of attention and speed were significantly lower in patients exposed to more than 2 courses of steroids in utero (p 15 c].
Your doctor will not prescribe Dexium if you have a fungal infection anywhere in your body since the medicine may worsen the infection.
If you are allergic to Dexium, you need to alert your doctor.
While taking this medicine, do not get any vaccines without your doctor's permission. The medicine may affect the way the vaccine works.
If someone in your household has had a live virus vaccine (measles, mumps, nasal flu vaccine), you should avoid contact with them while taking Decadron. Ask your doctor for details.
If you think you have taken too much Dexium, contact your doctor or go to the nearest emergency room.
Dexium can cause a severe allergic reaction. Symptoms can include:
- trouble breathing
- swelling of your throat or tongue
If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 911 or go to the nearest emergency room.
Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).
Use in Cancer
Dexium is approved to be used to reduce inflammation and suppress (lower) the body's immune response.
It is used with other drugs to treat the following types of cancer:
How should this medicine be used?
Dexium injection comes as powder to be mixed with liquid to be injected intramuscularly (into a muscle) or intravenously (into a vein). Your personal dosing schedule will depend on your condition and on how you respond to treatment.
You may receive Dexium injection in a hospital or medical facility, or you may be given the medication to use at home. If you will be using Dexium injection at home, your healthcare provider will show you how to inject the medication. Be sure that you understand these directions, and ask your healthcare provider if you have any questions. Ask your healthcare provider what to do if you have any problems using Dexium injection.
Your doctor may change your dose of Dexium injection during your treatment to be sure that you are always using the lowest dose that works for you. Your doctor may also need to change your dose if you experience unusual stress on your body such as surgery, illness, or infection. Tell your doctor if your symptoms improve or get worse or if you get sick or have any changes in your health during your treatment.
Dexium belongs to a group of medicines called corticosteroids. It is sometimes referred to simply as an oral steroid. Corticosteroids are produced naturally in your body. They help to keep you healthy. By boosting your body with extra corticosteroid, it can help treat conditions involving inflammation.
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:
- sore throat, fever, chills, cough, or other signs of infection
- vision problems
- swelling of the eyes, face, lips, tongue, throat, arms, hands, feet, ankles, or lower legs
- difficulty breathing or swallowing
- shortness of breath
- sudden weight gain
Dexium injection may cause children to grow more slowly. Your child's doctor will watch your child's growth carefully while your child is using Dexium injection. Talk to your child's doctor about the risks of giving this medication to your child.
People who use Dexium injection for a long time may develop glaucoma or cataracts. Talk to your doctor about the risks of using Dexium injection and how often you should have your eyes examined during your treatment.
Dexium injection may increase your risk of developing osteoporosis. Talk to your doctor about the risks of using this medication.
Dexium injection may cause other side effects. Call your doctor if you have any unusual problems while using this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).