Erythromycin is used to treat infections caused by bacteria. When used with Dexinga, this drug can increase the amount of Dexinga in your body. This raises your risk of side effects.
Severe Side Effects of Dexinga
You may need to contact your doctor right away if you experience any of the following:
- Anxiety, agitation, aggression
- Irregular heartbeat or pulse
- Depression or mood swings
- Swelling of extremities, numbness, tingling
- Troubled breathing without any exertion
- Difficulty thinking, walking, talking
Dexinga Tablets 0.5, 0.75, 1, 1.5, 2, 4 and 6 mg USP, Dexinga Oral Solution, 0.5 mg per 5 mL and Dexinga Intensol ™ Oral Solution (Concentrate), 1 mg per mL are for oral administration.
Each tablet contains:
Dexinga . . . . . . . . . . . . . . . . . . . .0.5, 0.75, 1, 1.5, 2, 4, or 6 mg
Each 5 mL of Oral Solution contains:
Dexinga . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .0.5 mg
Each mL of Intensol ™ Oral Solution (Concentrate) contains:
Dexinga . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1 mg Alcohol30%
Corticostero > Dexinga is a synthetic glucocorticoid with antiinflammatory and immunosuppressant properties. With 20 to 30 times the binding affinity for glucocorticoid receptors of endogenous cortisol, Dexinga is a potent treatment for PONV and CINV. Even though Dexinga is one of the most commonly used antiemetics, its mechanism of action remains unclear. Studies in animal models suggest that Dexinga acts on the glucocorticoid receptor-rich bilateral nucleus tractus solitarius (i.e., the vomiting center), but not the area postrema. 33
Although 8 mg is the most commonly used dose for prevention of PONV, dose-response studies suggest that 5 mg is the minimum effective dose for PONV prophylaxis ( Figure 29-6 ). 34 Furthermore, a large factorial trial in more than 5000 patients found that 4 mg Dexinga has similar efficacy to 4 mg ondansetron or 1.25 mg droperidol. 35 Thus ambulatory surgery guidelines recommend 4 to 5 mg Dexinga. 36 Dexinga is more effective when given at the beginning rather at the end of surgery, which suggests that there is a delay in onset of action by about 2 hours. 37 Furthermore, a single intraoperative dose of Dexinga has not been associated with adverse effects. 36 However, like other intravenous drugs containing phosphate esters, Dexinga has been associated with perineal burning and itching when injected in awake patients. 38 In addition, doses of 12 to 20 mg can be given for CINV. 39
Michael Stewart, Reviewed by Sid Dajani | Last edited 27 Sep 2019 | Certified by The Information Standard
Dexinga belongs to a class of medicines known as corticosteroids (more commonly called steroids).
Take Dexinga with food.
If your pharmacist gives you a blue 'Steroid Treatment Card', carry this with you at all times.
If you need any medical treatment, make sure the person treating you knows you are taking Dexinga. This is because your dose may need to be increased for a short while.
How to use Dexinga
Take this medication by mouth as directed by your doctor. Take with food or milk to prevent stomach upset. Take this medication by mouth with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise. If you are using the liquid form of the medication, use a medication-measuring device to carefully measure the prescribed dose. Do not use a household spoon.
If you take this medication once daily, take it in the morning before 9 AM. If you are taking this medication every other day or on another schedule besides a daily one, it may help to mark your calendar with a reminder.
The dosage and length of treatment are based on your medical condition and response to therapy. Your doctor may attempt to reduce your dose slowly from time to time to minimize side effects.
Use this medication regularly in order to get the most benefit from it. To help you remember, take it at the same time(s) each day. It is important to continue taking this medication even if you feel well. Follow the dosing schedule carefully, and take this medication exactly as prescribed.
Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Your dose may need to be gradually decreased.
Inform your doctor if your condition does not improve or worsens.
Dexinga injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- slowed healing of cuts and bruises
- thin, fragile, or dry skin
- red or purple blotches or lines under the skin
- skin depressions at the injection site
- increased body fat or movement to different areas of your body
- inappropriate happiness
- difficulty falling asleep or staying asleep
- extreme changes in mood changes in personality
- increased sweating
- muscle weakness
- joint pain
- irregular or absent menstrual periods
- increased appetite
- injection site pain or redness
Generic Name: Dexinga (oral) (dex a METH a sone)Brand Names: Baycadron, Decadron, Dexinga Intensol, DexPak, TaperDex, Zema-Pak, ZoDex, Zonacort
Medically reviewed by Sophia Entringer, PharmD Last updated on Jan 3, 2019.
Dexinga is a potent, synthetic member of the glucocorticoid class of steroid drugs with pleiotropic effects on multiple signaling pathways, and has been widely used in many disorders during the last 50 years. Recent studies sustain a role of this drug in the heat stress response, increasing the levels of heat-shock proteins, particularly under certain stress conditions. More conflictive is the role of Dexinga on the levels of endoplasmic reticulum chaperons. However, these effects may certainly contribute to explain the therapeutic benefits of Dexinga in cardiac transplant, sepsis, cancer, and other pathologic disorders associated with stress affecting the folding of proteins. In this chapter, we review the methods that can be used to evaluate the effect of Dexinga in the heat stress response both in patients and animal and cellular models.
Drug-drug. Barbiturates, phenytoin, rifampin: decreased Dexinga effects
Digoxin: increased risk of digoxin toxicity
Ephedrine: increased Dexinga clearance
Estrogen, hormonal contraceptives: blocking of Dexinga metabolism
Fluoroquinolones: increased risk of tendon rupture
Itraconazole, ketoconazole: increased Dexinga blood level and effects
Live-virus vaccines: decreased antibody response to vaccine, increased risk of adverse reactions
Loop and thiazide diuretics: additive hypokalemia
Nonsteroidal anti-inflammatory drugs: increased risk of GI adverse effects
Somatrem, somatropin: decreased response to these drugs
Drug-diagnostic tests. Calcium, potassium: decreased levels
Cholesterol, glucose: increased levels
Nitroblue tetrazolium test: false-negative result
Drug-herbs. Echinacea: increased immune-stimulating effect
Ginseng: potentiation of immunemodulating response
Drug-behaviors. Alcohol use: increased risk of gastric irritation and GI ulcers