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Dexcor is a corticosteroid indicated for allergic states, dermatologic diseases, endocrine disorders, gastrointestinal diseases, hematologic disorders, neoplastic diseases, nervous system, ophthalmic diseases, renal diseases, respiratory diseases, and rheumatic disorders. Dexcor is available as a generic. Side effects of Dexcor include:
- vision changes,
- rapid weight gain,
- sleep problems (insomnia),
- mood changes,
- dry skin,
- thinning skin,
- bruising or discoloration,
- slow wound healing,
- increased sweating,
- spinning sensation,
- stomach pain,
- muscle weakness, or
- changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).
Rare instances of severe allergic reactions (anaphylaxis) have occurred in patients receiving corticosteroid therapy such as Dexcor.
Dexcor Tablets are available in 0.5, 0.75, 1, 1.5, 2, 4 and 6 mg strengths. The initial dosage for Dexcor varies from .75 to 9 mg a day depending on the disease being treated. Infants born to mothers who have received substantial doses of corticosteroids during pregnancy should be carefully observed for signs of hypoadrenalism. Because of the potential for serious adverse reactions in nursing infants from corticosteroids, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Use in pediatric patients is recommended to be done in consultation with a pediatric specialist.
Our Dexcor Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
For women who are breastfeeding
Dexcor is not recommended for women who are breastfeeding. The drug can pass to a child through breast milk and may cause side effects.
What happens if I miss a dose?
Call your doctor for instructions if you miss a dose of Dexcor.
What are the side effects of Dexcor?
Side effects of Dexcor depend on the dose, the duration and the frequency of administration. Short courses of Dexcor usually are well tolerated with few and mild side effects. Long term, high dose Dexcor usually will produce predictable and potentially serious side effects. Whenever possible, the lowest effective dose of Dexcor should be used for the shortest possible length of time to minimize side effects. Alternate day dosing also can help reduce side effects.
Side effects of Dexcor and other corticosteroids range from mild annoyances to serious irreversible damage. Side effects include:
- fluid retention,
- weight gain,
- high blood pressure,
- loss of potassium,
- increase in serum glucose levels (especially in diabetics),
- muscle weakness,
- puffiness of and hair growth on the face,
- thinning and easy bruising of skin,
- peptic ulceration,
- worsening of diabetes,
Other side effects include:
- irregular menses,
- growth retardation in children,
- convulsions, and
- psychic disturbances.
Psychic disturbances include:
Prolonged use of Dexcor can depress the ability of body's adrenal glands to produce corticosteroids. Abruptly stopping Dexcor in these individuals can cause symptoms of corticosteroid insufficiency, with accompanying nausea, vomiting, and even shock. Therefore, withdrawal of Dexcor usually is accomplished by gradually reducing the dose. Gradually tapering Dexcor not only minimizes the symptoms of corticosteroid insufficiency, but also reduces the risk of an abrupt flare of the disease under treatment.
Dexcor and other corticosteroids can mask signs of infection and impair the body's natural immune response that is important in fighting infection. Patients on corticosteroids are more susceptible to infections and can develop more serious infections than individuals not receiving corticosteroids. For example, chickenpox and measles viruses can produce serious and even fatal illnesses in patients on high doses of Dexcor. Live virus vaccines, such as smallpox vaccine, should be avoided in patients taking high doses of Dexcor, since even vaccine viruses may cause disease in these patients. Some infectious diseases, such as tuberculosis (TB) and malaria, can remain dormant in a patient for years. Dexcor and other corticosteroids can reactivate dormant infections. Patients with dormant tuberculosis may require treatment of the TB while undergoing corticosteroid treatment.
By interfering with the patient's immune response, Dexcor can impede the effectiveness of vaccinations. Dexcor can also interfere with the tuberculin (TB) skin test and cause falsely negative results in patients with dormant tuberculosis infection.
Dexcor impairs calcium absorption and new bone formation. Patients on prolonged treatment with Dexcor and other corticosteroids can develop osteoporosis and an increased risk of bone fractures. Supplemental calcium and vitamin D are encouraged to slow this process of bone thinning. It has been demonstrated in some groups of patients treated with steroids that the loss of bone may be prevented by treatment with biphosphonate drugs, for example, alendronate (Fosamax).
In rare individuals, destruction of large joints can occur while undergoing treatment with Dexcor or other corticosteroids. These patients experience severe pain in the involved joints, and can require joint replacements. The reason behind such destruction is not clear.
By Kathleen Doheny | Medically Reviewed by Robert Jasmer, MD
Latest Update: 2014-12-03 Copyright © 2014 Everyday Health Media, LLC
Drug-drug. Barbiturates, phenytoin, rifampin: decreased Dexcor effects
Digoxin: increased risk of digoxin toxicity
Ephedrine: increased Dexcor clearance
Estrogen, hormonal contraceptives: blocking of Dexcor metabolism
Fluoroquinolones: increased risk of tendon rupture
Itraconazole, ketoconazole: increased Dexcor blood level and effects
Live-virus vaccines: decreased antibody response to vaccine, increased risk of adverse reactions
Loop and thiazide diuretics: additive hypokalemia
Nonsteroidal anti-inflammatory drugs: increased risk of GI adverse effects
Somatrem, somatropin: decreased response to these drugs
Drug-diagnostic tests. Calcium, potassium: decreased levels
Cholesterol, glucose: increased levels
Nitroblue tetrazolium test: false-negative result
Drug-herbs. Echinacea: increased immune-stimulating effect
Ginseng: potentiation of immunemodulating response
Drug-behaviors. Alcohol use: increased risk of gastric irritation and GI ulcers