Dexalin tablets

Dexalin

  • Active Ingredient: Dexamethasone
  • 1 mg, 0.5 mg
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What is Dexalin?

The active ingredient of Dexalin brand is dexamethasone. Dexamethasone is a steroid that prevents the release of substances in the body that cause inflammation.

Used for

Dexalin is used to treat diseases such as: Addison's Disease, Adrenal Insufficiency, Adrenocortical Insufficiency, Adrenogenital Syndrome, Allergic Rhinitis, Ankylosing Spondylitis, Aphthous Ulcer, Aspiration Pneumonia, Asthma, Asthma, acute, Atopic Dermatitis, Bronchopulmonary Dysplasia, Bursitis, Cerebral Edema, Chorioretinitis, Croup, Cushing's Syndrome, Dermatitis Herpetiformis, Eczema, Epicondylitis, Tennis Elbow, Erythroblastopenia, Evan's Syndrome, Gouty Arthritis, Hemolytic Anemia, Hypercalcemia of Malignancy, Idiopathic Thrombocytopenic Purpura, Inflammatory Bowel Disease, Inflammatory Conditions, Iridocyclitis, Iritis, Juvenile Rheumatoid Arthritis, Keratitis, Leukemia, Loeffler's Syndrome, Lymphoma, Meningitis, Haemophilus influenzae, Meningitis, Listeriosis, Meningitis, Meningococcal, Meningitis, Pneumococcal, Mountain Sickness / Altitude Sickness, Multiple Myeloma, Multiple Sclerosis, Mycosis Fungoides, Nausea/Vomiting, Chemotherapy Induced, Neurosarcoidosis, Pemphigus, Plaque Psoriasis, Psoriasis, Psoriatic Arthritis, Pulmonary Tuberculosis, Rheumatoid Arthritis, Sarcoidosis, Seborrheic Dermatitis, Shock, Synovitis, Systemic Lupus Erythematosus, Thrombocytopenia, Toxic Epidermal Necrolysis, Transverse Myelitis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Posterior.

Side Effect

Possible side effects of Dexalin include: lower back or side pain; heartburn and/or indigestion (severe and continuous); decrease in height; weight gain; vomiting; vomiting of material that looks like coffee grounds; diarrhea; painful or difficult urination.

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Dexalin injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • headache
  • slowed healing of cuts and bruises
  • thin, fragile, or dry skin
  • red or purple blotches or lines under the skin
  • skin depressions at the injection site
  • increased body fat or movement to different areas of your body
  • inappropriate happiness
  • difficulty falling asleep or staying asleep
  • extreme changes in mood changes in personality
  • depression
  • increased sweating
  • muscle weakness
  • joint pain
  • irregular or absent menstrual periods
  • hiccups
  • increased appetite
  • injection site pain or redness

For pregnant women

Dexalin is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should only be used if the potential benefit justifies the potential risk to the fetus.

How it works

Dexalin belongs to a class of drugs called steroids. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

For conditions with inflammation: With certain conditions, inflammation can cause the immune system to be overactive. This can damage the body's tissues. Steroids such as Dexalin help block the immune system’s response to inflammation, which helps prevent this damage.

For adrenal insufficiency: The adrenal gland helps control certain body functions. These functions include managing blood glucose, fighting infection, and controlling stress. In people with adrenal insufficiency, the adrenal gland releases lower amounts of certain hormones. Dexalin helps replace these hormones.

Dexalin oral tablet doesn’t cause drowsiness, but it can cause other side effects.

Before taking Dexalin

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking Dexalin it is important that your doctor knows:

  • If you have high blood pressure (hypertension).
  • If you have had a heart attack, or if you have any other heart problems.
  • If you have any problems with the way your liver works, or if you have any problems with the way your k >

How to store Dexalin

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

Pharmacology and mechanism of action

Corticostero >Dexalin are approximately 30 times more potent than cortisol. Anti-inflammatory effects are complex, but primarily via inhibition of inflammatory cells and suppression of expression of inflammatory mediators. Use is for treatment of inflammatory and immune-mediated disease. This Dexalin solution differs from Dexalin sodium phosphate in that the sodium phosphate form is water soluble and appropriate for IV administration. Dexalin solution is in a polyethylene glycol vehicle that should not be administered rapidly IV. Dexalin-21-isonicotinate is a suspension registered for IM use. After an injection of 10 mg (total dose) to horses, the half-life was 2.5-5 hours, and the volume of distribution (VDss) was 1.7 L/kg. Oral administration of the same dose had a half-life of 4.3 hours and bioavailability (F) of 61%, with a peak concentration at 1.3 hours. The suspension, (Dexalin-21-isonicotinate) has a slow-release and produces a 39 hour half-life in horses and suppresses cortisol for 140 hours.

Dexalin for Dogs and Cats

Veterinarians prescribe Dexalin for dogs and cats when they need to treat immune system problems such as asthma, hives, itching, inflammation, and skin and eye problems.

Intravenous (IV) Dexalin is approved for use in cattle and horses.

Abstract

Dexalin is a potent, synthetic member of the glucocorticoid class of steroid drugs with pleiotropic effects on multiple signaling pathways, and has been widely used in many disorders during the last 50 years. Recent studies sustain a role of this drug in the heat stress response, increasing the levels of heat-shock proteins, particularly under certain stress conditions. More conflictive is the role of Dexalin on the levels of endoplasmic reticulum chaperons. However, these effects may certainly contribute to explain the therapeutic benefits of Dexalin in cardiac transplant, sepsis, cancer, and other pathologic disorders associated with stress affecting the folding of proteins. In this chapter, we review the methods that can be used to evaluate the effect of Dexalin in the heat stress response both in patients and animal and cellular models.

Dexalin Dosage

Doses of Dexalin in eye drop, cream and other forms differ from patient to patient and depend on the condition being treated.

For oral forms, strengths range from 0.5 milligrams (mg) to 6 mg per tablet.

The prescribed dose depends on the medical condition. In general, dosage for oral solutions and tablets are:

  • For adults: 0.75 to 9 mg a day, adjusted as needed.
  • For children: 0.02 to 0.3 mg per kilogram (2.2 pounds) of body weight a day, spread out throughout the day.

The dose for intravenous and intramuscular injections ranges from 0.5 to 9 mg daily, but can be higher or lower.

Getting the most from your treatment

  • If your course of treatment is due to last more than three weeks, you will be given a 'Steroid Treatment Card' which says that you are on steroids and contains some important advice for you. It is important that you read this card and carry it with you at all times. It also contains details about your dose, how long you have been taking Dexalin for, and who prescribed it for you. Please make sure that this information is kept up to date. If you are having an operation or dental treatment or any treatment for an injury, tell the person carrying out the treatment that you are taking Dexalin and show them your treatment card. This is because your dose may need adjusting.
  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. Your doctor will want you to have tests from time to time to make sure you remain free from some of the unwanted side-effects of treatment.
  • Dexalin can suppress your immune system, so it is important if you become ill that you make an appointment to see your doctor straightaway. Also, if you come into contact with anyone who has measles, shingles or chickenpox (or anyone who suspects they might have them), you must see your doctor as soon as possible.
  • Some vaccines are not suitable for you while you are being treated with Dexalin. If you need any immunisations, make sure you mention that you are taking an oral steroid.
  • If you buy any medicines, check with your pharmacist that they are suitable to take with Dexalin.

Antifungal drugs

When used with Dexalin, certain drugs used to treat fungal infections can increase the level of Dexalin in your blood. This can raise your risk of side effects. Examples of these drugs include:

  • ketoconazole
  • itraconazole
  • posaconazole
  • voriconazole

Amphotericin B is another drug used to treat fungal infections. Using this drug with Dexalin raises your risk of low potassium levels. (Potassium is a mineral that helps your nerves, muscles, and organs work normally.) This can cause muscle cramps, weakness, tiredness, and an irregular heartbeat.

Before taking this medicine

You should not use Dexalin if you are allergic to it, or if you have:

COMMON BRAND(S): Decadron

GENERIC NAME(S): Dexalin

Dexalin is used to treat conditions such as arthritis, blood/hormone/immune system disorders, allergic reactions, certain skin and eye conditions, breathing problems, certain bowel disorders, and certain cancers. It is also used as a test for an adrenal gland disorder (Cushing's syndrome).

This medication is a corticosteroid hormone (glucocorticoid). It decreases your body's natural defensive response and reduces symptoms such as swelling and allergic-type reactions.

How to use Dexalin

Take this medication by mouth as directed by your doctor. Take with food or milk to prevent stomach upset. Take this medication by mouth with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise. If you are using the liquid form of the medication, use a medication-measuring device to carefully measure the prescribed dose. Do not use a household spoon.

If you take this medication once daily, take it in the morning before 9 AM. If you are taking this medication every other day or on another schedule besides a daily one, it may help to mark your calendar with a reminder.

The dosage and length of treatment are based on your medical condition and response to therapy. Your doctor may attempt to reduce your dose slowly from time to time to minimize side effects.

Use this medication regularly in order to get the most benefit from it. To help you remember, take it at the same time(s) each day. It is important to continue taking this medication even if you feel well. Follow the dosing schedule carefully, and take this medication exactly as prescribed.

Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Your dose may need to be gradually decreased.

Inform your doctor if your condition does not improve or worsens.

Why it's used

The Dexalin oral tablet is used to treat conditions that cause inflammation, conditions related to immune system activity, and hormone deficiency. These conditions include:

  • inflammation
  • allergic reactions
  • rheumatoid arthritis and other rheumatic diseases, including ankylosing spondylitis, psoriatic arthritis, juvenile rheumatoid arthritis, lupus, and acute gouty arthritis
  • skin diseases, such as pemphigus, severe erythema multiforme (Stevens-Johnson syndrome), exfoliative dermatitis, bullous dermatitis herpetiformis, severe seborrheic dermatitis, severe psoriasis, or mycosis fungoides
  • flare-ups of intestinal disease, such as ulcerative colitis
  • flare-ups of multiple sclerosis or myasthenia gravis
  • pre-treatment for chemotherapy to reduce inflammation and side effects from cancer medications
  • adrenal insufficiency (a condition where the adrenal glands don’t produce enough hormones)


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