Dermasone

Dermasone

  • Active Ingredient: Clobetasol
  • 15 mg
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What is Dermasone?

The active ingredient of Dermasone brand is clobetasol. Clobetasol propionate, USP has the molecular formula C25H32CIFO5 and a molecular weight of 467. It is a white to cream-colored crystalline powder insoluble in water. Clobetasol propionate ointment USP, 0.05% contains Clobetasol propionate 0.5 mg/g in a base of propylene glycol, sorbitan sesquioleate, and white petrolatum.

Used for

Dermasone is used to treat diseases such as: Anal Itching, Atopic Dermatitis, Cutaneous T-cell Lymphoma, Dermatitis, Dermatological Disorders, Eczema, Lichen Planus, Lichen Sclerosus, Necrobiosis Lipoidica Diabeticorum, Plantar Fibromatosis, Psoriasis, Seborrheic Dermatitis.

Side Effect

Possible side effects of Dermasone include: voice changes; lightening of normal skin color; headache; Burning sensation of the skin; sore throat; thinning of the hair; trouble swallowing.

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Dermasone Cream Dosage and Administration

Apply a thin layer of Dermasone propionate cream, 0.05% (emollient) to the affected skin areas twice daily and rub in gently and completely. Wash hands after each application.

Dermasone propionate cream, 0.05% (emollient) is a super-high potency topical corticostero >treatment should be limited to 2 consecutive weeks, and amounts greater than 50 grams per week should not be used.

In moderate to severe plaque-type psoriasis, Dermasone propionate cream, 0.05% (emollient) applied to 5% to 10% of body surface area can be used for up to 4 weeks. The total dosage should not exceed 50 grams per week. When dosing for more than 2 weeks, any additional benefits of extending treatment should be weighed against the risk of HPA suppression. Therapy should be discontinued when control has been achieved. If no improvement is seen within 2 weeks, reassessment of diagnosis may be necessary. Treatment beyond 4 consecutive weeks is not recommended.

Dermasone propionate cream, 0.05% (emollient) should not be used with occlusive dressings.

How to store Dermasone propionate

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

More common side effects

The most common side effects of Dermasone include:

  • burning, irritation, and itching of the skin where you applied the drug

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Can Dermasone propionate cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. You can reduce the risk of side-effects from topical corticosteroids like Dermasone propionate, by applying the preparation thinly, no more than twice a day, and to the affected areas only.

Carcinogenesis, Mutagenesis, Impairment of Fertility

Carcinogenesis Long-term animal studies have not been performed to evaluate the carcinogenic potential of Dermasone propionate.

Mutagenesis Dermasone propionate was nonmutagenic in three different test systems: the Ames test, the Saccharomyces cerevisiae gene conversion assay, and the E. Coli B WP2 fluctuation test.

Impairment of Fertility Studies in the rat following oral administration at dosage levels up to 50 mg/kg per day revealed no significant effect on the males. The females exhibited an increase in the number of resorbed embryos and a decrease in the number of living fetuses at the highest dose.

Dermasone topical side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

worsening of your skin condition;

redness, warmth, swelling, oozing, or severe irritation of any treated skin;

blurred vision, tunnel vision, eye pain, or seeing halos around lights;

high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor; or

possible signs of absorbing this medicine through your skin--weight gain in your face and shoulders, slow wound healing, skin discoloration, thinning skin, increased body hair, tiredness, mood changes, menstrual changes, sexual changes.

Common side effects may include:

burning, itching, swelling, or irritation of treated skin;

dry or cracking skin;

redness or crusting around your hair follicles;

stretch marks, thinning skin;

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Allergy warning

Dermasone may cause allergic skin reactions that are difficult to heal. Your doctor may do a skin patch test to check if you have an allergic skin reaction. Symptoms of a skin reaction can include:

  • skin irritation that doesn’t heal

This drug may also cause severe allergic reactions. Symptoms can include:

  • trouble breathing
  • swelling of your throat or tongue

If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 911 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

Serious side effects

Serious side effects are rare. They happen to 1 in 10,000 people who use Dermasone. You're more likely to have a serious side effect if you use Dermasone on a large area of skin for a long time.

Using Dermasone for a long time can make your skin thinner or cause stretch marks. Stretch marks are likely to be permanent, but they usually fade over time.

Dermasone cream contains cetostearyl alcohol, which may cause a skin reaction in the area you are treating, and chlorocresol, which may cause an allergic reaction.

Stop using Dermasone and tell a doctor straight away if:

  • your skin becomes redder or swollen, you get white patches on your skin or yellow fluid is weeping from your skin. These are signs of a new skin infection or an existing one getting worse
  • you are using Dermasone for psoriasis and you get raised bumps filled with pus (pustules) under the skin
  • you have a very upset stomach or vomiting, muscle weakness, loss of appetite, weight loss, you feel dizzy, faint or very tired, or your mood changes. These can be signs of adrenal gland problems
  • you feel confused, sleepy, more thirsty or hungry than usual, pee more often, have hot flushes, start breathing quickly or your breath smells of fruit. These can be signs of high blood sugar
  • you have any new problems with your eyesight after starting to use Dermasone


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