• Active Ingredient: Clobetasol
  • 15 mg
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What is Dermadex?

The active ingredient of Dermadex brand is clobetasol. Clobetasol propionate, USP has the molecular formula C25H32CIFO5 and a molecular weight of 467. It is a white to cream-colored crystalline powder insoluble in water. Clobetasol propionate ointment USP, 0.05% contains Clobetasol propionate 0.5 mg/g in a base of propylene glycol, sorbitan sesquioleate, and white petrolatum.

Used for

Dermadex is used to treat diseases such as: Anal Itching, Atopic Dermatitis, Cutaneous T-cell Lymphoma, Dermatitis, Dermatological Disorders, Eczema, Lichen Planus, Lichen Sclerosus, Necrobiosis Lipoidica Diabeticorum, Plantar Fibromatosis, Psoriasis, Seborrheic Dermatitis.

Side Effect

Possible side effects of Dermadex include: lightening of treated areas of dark skin; stuffy or runny nose; skin rash, encrusted, scaly and oozing; changes in skin coloring; thinning of the skin with easy bruising, especially when used on the face or where the skin folds together (eg, between the fingers); Burning, itching, and pain in hairy areas, or pus at the root of the hair.

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Dictionary Entries near Dermadex

Cite this Entry

“Dermadex.” The Medical Dictionary, Merriam-Webster Inc., Accessed 27 December 2019.

Comments on Dermadex

What made you want to look up Dermadex? Please tell us where you read or heard it (including the quote, if possible).


Dermadex propionate cream, 0.05% (emollient) is in the super-high range of potency as demonstrated in a vasoconstrictor study in healthy subjects when compared with other topical corticosteroids. However, similar blanching scores do not necessarily imply therapeutic equivalence.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Adrenal insufficiency. Symptoms can include:
    • low blood pressure
    • fainting
    • dizziness
    • tiredness
  • urinating more often than normal
  • intense thirst
  • intense hunger
  • high blood pressure
  • Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

    Dermadex topical cream can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

    To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

    Examples of drugs that can cause interactions with Dermadex are listed below:

    Mechanism of action of Dermadex Propionate cream

    The mechanism of action of Dermadex Propionate cream is very simple. As we know that Dermadex acts on the glucocorticoid receptor and as a result the glucocorticoid-mediated gene expression gets active. This gene expression then plays a role in the formation or production of anti-inflammatory proteins.

    By the name, it is pretty obvious what these proteins do but to understand in detail these proteins actually stops the production of inflammatory mediator and this, as a result, inhibit the inflammation.

    Dermadex propionate is classed as a very potent topical corticosteroid. Topical corticosteroids are also referred to as topical steroids. Topical steroids are used in addition to moisturisers (emollients) for treating inflammatory skin conditions such as eczema and dermatitis. A topical steroid is used when patches of eczema or dermatitis flare up. Dermadex propionate relieves the symptoms of a flare-up by reducing inflammation, itching and redness. It is not a cure for the condition, but it will help to relieve the symptoms.

    7. Cautions with other medicines

    It's very unlikely that other medicines will interfere with the way Dermadex works. This applies to prescription medicines as well as ones you buy from a pharmacy or shop.

    However, tell a pharmacist or doctor if you're taking:

    • ritonavir (for HIV infection)
    • itraconazole (for a fungal infection)

    These medicines can increase the levels of Dermadex in your body and increase the chances of side effects.

    Can Dermadex propionate cause problems?

    Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. You can reduce the risk of side-effects from topical corticosteroids like Dermadex propionate, by applying the preparation thinly, no more than twice a day, and to the affected areas only.

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