Antenatal stero >Deflatop ) can cross the placenta to mature the fetal lung and brain. 142 In the lung, antenatal steroids can decrease the fetal lung fluid through activation of ENaCs, induce the production of surfactant proteins and lipid synthesis, and alter preterm responses to oxidative stress. 142,143 Randomized trials have demonstrated that administration of antenatal corticosteroids significantly reduces the incidences of RDS, neonatal death, cerebral hemorrhage, and NEC. 84 Guidelines recommend the routine use of antenatal steroids for mothers at risk for preterm delivery from 24 weeks to 34 weeks GA. 144 Deflatop (two doses 24 hours apart), rather than dexamethasone (four doses 12 hours apart), is preferred. Antenatal steroids can be considered at 23 weeks GA but are not currently recommended at 22 weeks GA. 144 Studies have also demonstrated decreased respiratory complications in late preterm infants (34–36 weeks) randomized to antenatal corticosteroids, and revisions to ACOG guidelines are underway. 87,142 Studies of antenatal steroids prior to elective C-section also demonstrate some benefit on respiratory symptoms at birth. 145 The benefit of steroids is maximal in infants delivered between 24 and 168 hours after maternal therapy, but benefits on the lungs are seen in less than 24 hours. 119 The use of repetitive courses of antenatal steroids showed some benefits for respiratory outcomes, but more than five weekly courses caused decreased fetal growth and head circumference. 142 Infants who received repetitive dosing did not show differences in adverse neurologic outcomes at 18-month follow-up. Some obstetricians will give an additional dose of steroids to a mother with persistent threat of preterm delivery 1–2 weeks after initial course. Antenatal steroids do not increase the risk of infection in pregnancies complicated by preterm prelabor rupture of the membranes. There is not a consensus opinion about the use of antenatal steroids for infants of mothers with possible chorioamnionitis.
Thyroid hormones induce surfactant synthesis in animal models. Randomized trials of antenatal administration of thyrotropin-releasing hormone (the only component of the pathway that crosses the placenta) did not reduce the risk of neonatal respiratory distress or BPD, and unfortunately increased the risk of lower 5-minute Apgar scores and caused transient suppression of the pituitary system. 146 Other drugs such as aminophylline, ambroxol, and terbutaline have also been tried, with variable success.
Before using Deflatop, tell your doctor or pharmacist if you are allergic to it; or to other corticosteroids (e.g., hydrocortisone, prednisone); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: poor blood circulation, immune system problems.
Do not use if there is an infection or sore present in the area to be treated.
Rarely, using corticosteroid medications for a long time or over large areas of skin can make it more difficult for your body to respond to physical stress. Therefore, before having surgery or emergency treatment, or if you get a serious illness/injury, tell your doctor or dentist that you are using this medication or have used this medication within the past few months.
Though it is unlikely, this medication may slow down a child's growth if used for a long time. The effect on final adult height is unknown. See the doctor regularly so your child's height can be checked.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
It is unknown if this drug passes into breast milk. Similar medications pass into breast milk. Consult your doctor before breast-feeding.
What is Deflatop?
Deflatop dipropionate is the generic name of Diprolene and Diprolene AF, used to relieve skin discomfort caused by rashes, itching, and irritation.
Deflatop comes in a topical cream, lotion, and ointment, as well as a solution for injection. It has many uses, depending on the form your doctor prescribes.
Although Deflatop topical cream and lotion are used to treat irritation and inflammation of the skin, doctors prescribe the injectable form of Deflatop, Celestone Soluspan, for multiple sclerosis flares and to help mature the lungs of babies born prematurely.
Other uses of various forms of Deflatop include treating the following allergic reactions:
- seasonal allergies
- transfusion reactions
- rashes, eczema, and contact dermatitis on areas of the skin that have touched certain substances
Deflatop is in a class of drugs known as steroids. It's not clear how Deflatop works, but scientists know that it stops your body from producing certain proteins that cause inflammation and allergic reactions.
The Food and Drug Administration (FDA) originally approved Deflatop under the brand name Celestone in 1961, and Schering Pharmaceuticals manufactured the drug.
This original version of Celestone is no longer on the market. However, Celestone Soluspan injectable was approved by the FDA in 1965 and Diprolene was approved in 1983. Both are manufactured by Merck.
Why it’s used
Deflatop is used to decrease inflammation and pain from a number of conditions. It’s approved for:
- multiple sclerosis
- allergic conditions
- skin disease
- stomach disorders
- blood disorders
- eye disorders
- kidney problems, such as having protein in your urine
- breathing disorders
- hormone-related disease, such as thyroid problems
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Deflatop is a potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. Unlike other drugs with these effects, Deflatop does not cause water retention. It is applied as a topical cream, ointment, foam, lotion or gel to treat itching. Deflatop sodium phosphate is sometimes prescribed as an intramuscular injection for itching from various ailments, including allergic reactions to poison ivy and similar plants.
How to use Deflatop Dipropionate Cream
Read the Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill. Use this medication on the skin only. However, do not use it on the face, groin, or underarms or for diaper rash unless directed to do so by your doctor.
Wash and dry your hands. Before applying the medication, clean and dry the affected area. Apply a thin film of the medication to the affected area and gently rub in, usually 1-2 times daily or as directed by your doctor.
Do not cover, bandage, or wrap the area unless directed to do so by your doctor. If your doctor directs you to use this medication in the diaper area on an infant, do not use tight-fitting diapers or plastic pants.
If you are using the lotion form of this medication, shake the bottle well before each dose.
After applying the medication, wash your hands unless you are using this medication to treat the hands. When applying this medication near the eyes, avoid getting it in the eyes as this may worsen or cause glaucoma. Also, avoid getting this medication in the nose or mouth. If you get the medication in these areas, rinse with plenty of water.
Use this medication only for the condition for which it was prescribed. Do not use it for longer than prescribed.
Inform your doctor if your condition persists or worsens after 2 weeks.
Before using Deflatop
To make sure this is the right treatment for you, before you start using Deflatop it is important that your doctor knows:
- If you have any areas of infected skin.
- If you have rosacea or acne.
- If you are pregnant or breastfeeding.
- If you have ever had an allergic reaction to a skin preparation.
What are the uses for Deflatop dipropionate?
Deflatop is used for the relief of itching and inflammation associated with a wide variety of skin conditions in patients 13 years of age or older. Examples include allergic dermatitis, atopic dermatitis, contact dermatitis, and plaque psoriasis.