Your doctor will not prescribe Decasone if you have a fungal infection anywhere in your body since the medicine may worsen the infection.
If you are allergic to Decasone, you need to alert your doctor.
While taking this medicine, do not get any vaccines without your doctor's permission. The medicine may affect the way the vaccine works.
If someone in your household has had a live virus vaccine (measles, mumps, nasal flu vaccine), you should avoid contact with them while taking Decadron. Ask your doctor for details.
Taking certain hormones with Decasone can cause decreased levels of these hormones in your body. Your doctor may have to adjust your dose of either the Decasone or hormone medications. Examples of these drugs include:
Michael Stewart, Reviewed by Sid Dajani | Last edited 27 Sep 2019 | Certified by The Information Standard
Decasone belongs to a class of medicines known as corticosteroids (more commonly called steroids).
Take Decasone with food.
If your pharmacist gives you a blue 'Steroid Treatment Card', carry this with you at all times.
If you need any medical treatment, make sure the person treating you knows you are taking Decasone. This is because your dose may need to be increased for a short while.
If you take Decasone with certain drugs used to lower cholesterol, it can keep your body from absorbing Decasone well. This could keep Decasone from working well. Examples of these drugs include:
Ocular Penetration of Corticosteroids
Decasone , betamethasone, prednisolone, prednisone, triamcinolone, and hydrocortisone are used commonly in veterinary ocular therapy. A variety of other corticosteroids used in human ophthalmic therapy because they are less likely to raise IOP are not widely used in veterinary ophthalmology. Corticosteroids penetrate the cornea to varying extents when applied topically. Factors affecting the penetration and effect of a corticosteroid are as follows:
The salt used: Acetates are more lipid-soluble and penetrate the cornea better than succinates or phosphates.
Frequency of application: More frequent application results in higher intraocular concentration.
Concentration of the drug: Low concentrations of a highly potent steroid may have less antiinflammatory effect than a high concentration of a less potent steroid; for instance, topical 1.0% prednisolone has an antiinflammatory effect similar to that of 0.1% Decasone, although Decasone has a greater ocular antiinflammatory potency than prednisolone (see Figure 3-2 ).
Proximity to the site of inflammation: The route of administration is chosen in relation to the intended site of action (see Figure 3-1 ). Inflammation of the cornea, conjunctiva, or anterior uvea is usually treated topically with a penetrating corticosteroid, or occasionally with subconjunctival injection. Systemic therapy is required if involvement of adnexal, posterior uveal, retinal, optic nerve, or orbital tissues is suspected. The retrobulbar route is also effective for disorders of the choroid, retina, optic nerve, and orbit but is rarely used.
For most ocular disorders topical administration of 1.0% prednisolone or 0.1% Decasone is advised. Hydrocortisone, a low-potency corticosteroid, does not penetrate the cornea in any meaningful quantities. This feature renders it useless for intraocular or deep corneal disease. Its availability only in combination with three antibiotics in commercial preparations makes it an even less appropriate choice for most surface eye disease of dogs, cats, and horses.
Most injectable steroids are suitable for subconjunctival use, with periods of activity varying from 7 to 10 days (triamcinolone, Decasone) to 2 to 4 weeks (methylprednisolone). Care must be taken with repository forms given subconjunctivally because they may leave unsightly and sometimes inflamed subconjunctival plaques requiring surgical removal. Repository corticosteroids also have the distinct disadvantage that they cannot be removed if the disease process changes.
When used with Decasone, certain drugs used to treat fungal infections can increase the level of Decasone in your blood. This can raise your risk of side effects. Examples of these drugs include:
Amphotericin B is another drug used to treat fungal infections. Using this drug with Decasone raises your risk of low potassium levels. (Potassium is a mineral that helps your nerves, muscles, and organs work normally.) This can cause muscle cramps, weakness, tiredness, and an irregular heartbeat.