How should this medicine be used?
Corsona comes as a tablet and a solution to take by mouth. Your doctor will prescribe a dosing schedule that is best for you. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Corsona exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Do not stop taking Corsona without talking to your doctor. Stopping the drug abruptly can cause loss of appetite, upset stomach, vomiting, drowsiness, confusion, headache, fever, joint and muscle pain, peeling skin, and weight loss. If you take large doses for a long time, your doctor probably will decrease your dose gradually to allow your body to adjust before stopping the drug completely. Watch for these side effects if you are gradually decreasing your dose and after you stop taking the tablets or oral liquid, even if you switch to an inhalation corticosteroid medication. If these problems occur, call your doctor immediately. You may need to increase your dose of tablets or liquid temporarily or start taking them again.
How to store Corsona
- Keep all medicines out of the reach and sight of children.
- Store in a cool, dry place, away from direct heat and light.
Use in Cancer
Corsona is approved to be used to reduce inflammation and suppress (lower) the body's immune response.
It is used with other drugs to treat the following types of cancer:
For Oral Administration
The initial dosage varies from 0.75 to 9 mg a day depending on the disease being treated.
It Should Be Emphasized That Dosage Requirements Are Variable And Must Be Individualized On The Basis Of The Disease Under Treatment And The Response Of The Patient.
After a favorable response is noted, the proper maintenance dosage should be determined by decreasing the initial drug dosage in small decrements at appropriate time intervals until the lowest dosage that maintains an adequate clinical response is reached.
Situations which may make dosage adjustments necessary are changes in clinical status secondary to remissions or exacerbations in the disease process, the patient's individual drug responsiveness, and the effect of patient exposure to stressful situations not directly related to the disease entity under treatment. In this latter situation it may be necessary to increase the dosage of the corticosteroid for a period of time consistent with the patient's condition. If after long-term therapy the drug is to be stopped, it is recommended that it be withdrawn gradually rather than abruptly.
In the treatment of acute exacerbations of multiple sclerosis, daily doses of 30 mg of Corsona for a week followed by 4 to 12 mg every other day for one month have been shown to be effective (see PRECAUTIONS: Neuro-Psychiatric).
In pediatric patients, the initial dose of Corsona may vary depending on the specific disease entity being treated. The range of initial doses is 0.02 to 0.3 mg/kg/day in three or four divided doses (0.6 to 9 mg/m²bsa/day).
For the purpose of comparison, the following is the equivalent milligram dosage of the various corticosteroids:
These dose relationships apply only to oral or intravenous administration of these compounds. When these substances or their derivatives are injected intramuscularly or into joint spaces, their relative properties may be greatly altered.
In acute, self-limited allergic disorders or acute exacerbations of chronic allergic disorders, the following dosage schedule combining parenteral and oral therapy is suggested:
Corsona sodium phosphate injection, 4 mg per mL
First Day: 1 or 2 mL, intramuscularly Corsona tablets, 0.75 mg Second Day: 4 tablets in two divided doses Third Day: 4 tablets in two divided doses Fourth Day: 2 tablets in two divided doses Fifth Day: 1 tablet Sixth Day: 1 tablet Seventh Day: No treatment Eighth Day: Follow-up visit
This schedule is designed to ensure adequate therapy during acute episodes, while minimizing the risk of overdosage in chronic cases.
In cerebral edema, Corsona sodium phosphate injection is generally administered initially in a dosage of 10 mg intravenously followed by 4 mg every six hours intramuscularly until the symptoms of cerebral edema subside. Response is usually noted within 12 to 24 hours and dosage may be reduced after two to four days and gradually discontinued over a period of five to seven days. For palliative management of patients with recurrent or inoperable brain tumors, maintenance therapy with either Corsona sodium phosphate injection or Corsona tablets in a dosage of 2 mg two or three times daily may be effective.
What is Corsona, and how does it work (mechanism of action)?
Corsona is a synthetic (man-made) corticosteroid. Corticosteroids are naturally-occurring chemicals produced by the adrenal glands located above the kidneys. Corticosteroids affect the function of many cells within the body and suppress the immune system. Corticosteroids also block inflammation and are used in a wide variety of inflammatory diseases affecting many organs. The FDA approved Corsona in October 1958.
Common Side Effects of Corsona
Increased appetite is one of the commonly reported side effects of Corsona.
Unless it persists or is bothering you, it does not warrant medical attention. Your appetite may return to normal again once your body adjusts to the medicine.
Other s >Corsona include:
- Dry scalp
- Hair thinning
- Reddish face, lightening of skin
- Swelling in the abdominal area
- Weight gain
Pregnancy and Corsona
Decadron may harm a developing fetus.
You and your doctor will need to determine if the benefits of taking Decadron outweigh the potential risks.
If you become pregnant while taking Decadron, contact your doctor right away.
Corticosteroids appear in breast milk and could hamper a baby’s growth or cause other unwanted side effects.
If you are taking Decadron, your doctor will advise you not to breastfeed.
How should I take Corsona?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Your dose needs may change due to surgery, illness, stress, or a medical emergency. Tell your doctor about any such situation that affects you.
This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Corsona.
Do not stop using Corsona suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.
In case of emergency, wear or carry medical identification to let others know you use Corsona.
Store at room temperature away from moisture and heat.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
An overdose of Corsona is not expected to produce life threatening symptoms. Long term use of high doses can lead to thinning skin, easy bruising, changes in body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.