The synthetic glucocortico >Cidoten , and prednisolone) have had a great influence on modern neurosurgery since their introduction in 1962 and in no area has this been seen more dramatically than in the management of brain tumours ( Galicich et al, 1961 ). These agents, typically for an adult in a loading dose of 12 mg dexamethasone intravenously and 4 mg 6-hourly thereafter, can rapidly relieve symptoms of raised intracranial pressure, lighten conscious level and reverse profound neurological deficits in some patients. Their use has greatly reduced the number of emergency operations for brain tumours required in neurosurgical units and has reduced the perioperative morbidity and mortality rates of all kinds of brain tumour. Their administration may be complicated by haematemesis or melaena and they should be used with caution, and covered with cimetidine, in cases of peptic ulcer. Subsequently they can be discontinued in cases of benign tumour, although sometimes they must be continued indefinitely in those cases of malignant brain tumour associated with persisting intracranial space-occupying mass effect.
How to use Cidoten
- Before you start using the preparation, read the manufacturer's printed information leaflet from ins >
Can Cidoten cause problems?
Along with its useful effects, Cidoten can cause unwanted side-effects which your doctor will discuss with you. The benefits of taking Cidoten usually outweigh the side-effects; however, they can sometimes be troublesome. The table below contains some of the most common ones associated with Cidoten. The best place to find a full list of the side-effects which can be associated with your medicine, is from the manufacturer's printed information leaflet supplied with the medicine. Alternatively, you can find an example of a manufacturer's information leaflet in the reference section below.
Although not everyone experiences side-effects, and some will improve as your body adjusts to the new medicine, speak with your doctor or pharmacist if you become concerned about any of the following:
Pregnancy and Cidoten
Cidoten is a FDA Pregnancy Category C drug, because steroids are known to cause birth defects in animals but the effects in pregnant humans haven't been studied adequately.
You should tell your doctor if you are pregnant or plan to become pregnant before taking this medication in any of its forms.
Cidoten, like most steroids, is found in breast milk and may stunt your baby's growth.
You should tell your doctor if you are breastfeeding or planning to breastfeed before using Cidoten in any form.
What Other Drugs Interact with Cidoten?
If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.
Interactions of Cidoten include:
- amphotericin B injection and potassium-depleting agents
- antibiotics, specifically macrolide
- oral anticoagulants
- antitubercular drugs
- digitalis glycosides
- estrogens, including oral contraceptives
- hepatic enzyme inducers (barbituarates, phenytoin, carbamazepine, rifampin)
- nonsteroidal anti-inflammatory agents (NSAIDs)
- diminished response to vaccines
This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.
Cidoten Dipropionate Lotion, USP 0.05% w/w is supplied as follows:
60 mL bottles (NDC 61748-475-60)
Store at 25°C, excursions permitted between 15° and 30°C. Protect from light and freezing. Store in carton until contents are used.
Why is this medication prescribed?
Cidoten topical is used to treat the itching, redness, dryness, crusting, scaling, inflammation, and discomfort of various skin conditions, including psoriasis (a skin disease in which red, scaly patches form on some areas of the body) and eczema (a skin disease that causes the skin to be dry and itchy and to sometimes develop red, scaly rashes). Cidoten is in a class of medications called corticosteroids. It works by activating natural substances in the skin to reduce swelling, redness, and itching.
How to use Cidoten Dipropionate Cream
Read the Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill. Use this medication on the skin only. However, do not use it on the face, groin, or underarms or for diaper rash unless directed to do so by your doctor.
Wash and dry your hands. Before applying the medication, clean and dry the affected area. Apply a thin film of the medication to the affected area and gently rub in, usually 1-2 times daily or as directed by your doctor.
Do not cover, bandage, or wrap the area unless directed to do so by your doctor. If your doctor directs you to use this medication in the diaper area on an infant, do not use tight-fitting diapers or plastic pants.
If you are using the lotion form of this medication, shake the bottle well before each dose.
After applying the medication, wash your hands unless you are using this medication to treat the hands. When applying this medication near the eyes, avoid getting it in the eyes as this may worsen or cause glaucoma. Also, avoid getting this medication in the nose or mouth. If you get the medication in these areas, rinse with plenty of water.
Use this medication only for the condition for which it was prescribed. Do not use it for longer than prescribed.
Inform your doctor if your condition persists or worsens after 2 weeks.
How should this medicine be used?
Cidoten comes in ointment, cream, lotion, gel, and aerosol (spray) in various strengths for use on the skin and as a foam to apply to the scalp. It is usually applied once or twice daily. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use Cidoten exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor. Do not apply it to other areas of your body or use it to treat other skin conditions unless directed to do so by your doctor.
Your skin condition should improve during the first 2 weeks of your treatment. Call your doctor if your symptoms do not improve during this time.
To use Cidoten topical, apply a small amount of ointment, cream, solution, gel, or lotion to cover the affected area of skin with a thin even film and rub it in gently.
To use the foam on your scalp, part your hair, apply a small amount of the medicine on the affected area, and rub it in gently. You may wash your hair as usual but not right after applying the medicine.
Cidoten foam may catch fire. Stay away from open fire, flames, and do not smoke while you are applying Cidoten foam, and for a short time afterward.
This medication is only for use on the skin. Do not let Cidoten topical get into your eyes or mouth and do not swallow it. Avoid use in the genital and rectal areas and in skin creases and armpits unless directed by your doctor.
If you are using Cidoten on a child's diaper area, do not use tight-fitting diapers or plastic pants. Such use may increase side effects.
Do not apply other skin preparations or products on the treated area without talking with your doctor.
Do not wrap or bandage the treated area unless your doctor tells you that you should. Such use may increase side effects.
Call your doctor if the treated area gets worse or if burning, swelling, redness, or oozing of pus develops.
How to store topical Cidoten
- Keep all medicines out of the reach and sight of children.
- Store in a cool, dry place, away from direct heat and light.
It's always important to share with your doctor and pharmacist all of the medications you are taking.
This includes your prescriptions medications, over-the-counter (OTC) drugs, vitamins and nutritional supplements nutritional shakes, protein powders, etc.), herbal remedies, and any illegal or recreational drugs.
Cidoten topical doesn't interact with other drugs.
However, if you are using another product that dries or irritates your skin while using Cidoten topical, your skin can become even more irritated.
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Cidoten is available in a number of different preparations. It is likely you will be prescribed a cream if the affected areas of your skin are moist or weeping, an ointment if your skin is dry, or a lotion for larger or hairy areas of skin. It is also available as an application for the scalp. Cidoten is not generally suitable for children, although short courses of up to two weeks may occasionally be prescribed for a child by a skin specialist doctor.
There are also Cidoten preparations available which contain an antibacterial agent (such as clioquinol, neomycin or fusidic acid), or an antifungal agent (such as clotrimazole). You may be prescribed one of these preparations for short-term use if your skin has become infected. They are typically used twice a day for one week only. Some preparations of Cidoten also contain an ingredient called salicylic acid. The salicylic acid in these formulations can help the steroid to be absorbed more effectively by your skin, but these are also only prescribed for short periods of time.
How to take Cidoten
- Before starting the treatment, read the manufacturer's printed information leaflet from ins >
- Systemicfungal infection
- Hypersensitivity to Cidoten
- Traumatic brain injury (high doses)
- Untreated serious infections
- Administration of live, attenuated vaccines is contraindicated in patients receiving immunosuppressive doses of corticosteroids
Effects of Drug Abuse
- See "What Are Side Effects Associated with Using Cidoten?"
- See "What Are Side Effects Associated with Using Cidoten?"
- Cirrhosis, ocularherpes simplex, hypertension, diverticulitis, hypothyroidism, myasthenia gravi, peptic ulcer disease, osteoporosis, ulcerative colitis, psychotic tendencies, untreated systemic infections, renal insufficiency, and pregnancy
- Not effective in treatment of respiratory distress syndrome in premature neonates
- Minimal sodium retention activity: however, may increase with high doses
- If used to treat adrenocortical insufficiency should also use mineralocorticoid
- Thromboembolic disorders
- Delayed wound healing
- Patients receiving corticosteroids should avoid chickenpox or measles-infected persons if unvaccinated
- Latenttuberculosis may be reactivated (monitor patients with positive tuberculin test)
- Some suggestion of slightly increased cleft palate risk if corticosteroids used in pregnancy, but not fully substantiated
- Prolonged corticosteroid use may result in elevated pressure in the eye, glaucoma, and/or cataracts
- Killed or inactivated vaccines may be administered; however, the response to such vaccines cannot be predicted
- Immunization procedures may be undertaken in patients who are receiving corticosteroids as replacement therapy in physiologic doses (Addison's disease)
- Serious neurologic events, some resulting in death, have been reported with epidural injection
- Specific events reported include, but are not limited to, spinal cordinfarction, paraplegia, quadriplegia, cortical blindness, and stroke
- These serious neurologic events have been reported with and without use of fluoroscopy
- Safety and effectiveness of epidural administration of corticosteroids have not been established, and corticosteroids are not approved for this use
- Use Cidoten during pregnancy with caution if benefits outweigh risks. Animal studies show risk and human studies are not available, or neither animal nor human studies were done.
- If breastfeeding, systemically administered corticosteroids enter breast milk and could suppress growth, interfere with endogenous corticosteroid production, or cause other effects; use with caution if breastfeeding. Consult your doctor.
You should not take Cidoten in any of its formulations if you're allergic to Cidoten or any other ingredient in the drug.
U.S. National Library of Medicine (0.00 / 0 votes) Rate this definition:
A glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes Cidoten particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p724)