Michael Stewart, Reviewed by Sid Dajani | Last edited 27 Sep 2019 | Certified by The Information Standard
Celestoderm belongs to a class of medicines known as corticosteroids (more commonly called steroids).
Your pharmacist will give you a blue 'Steroid Treatment Card'. Carry this with you at all times.
If you need any medical treatment, make sure the person treating you knows you are taking Celestoderm. This is because your dose may need to be increased for a short while.
A combination of calcipotriol and Celestoderm ointment, used at bedtime for 7 days a week and for a period of 12 weeks at the nail folds, the nail plate, and the hyponychium resulted in a mean 72% Nail Psoriasis Severety Index (NAPSI) improvement mainly on hyperkeratosis and onycholysis. 79 Clobetasol 8% nail lacquer used in combination with tacalcitol ointment at bedtime on weekends and tacalcitol on weekdays under occlusion resulted in 78% decrease of NAPSI with excellent tolerability. 80 The efficacy of PDL plus topical tazarotene 0.1% gel once a month for 6 months versus tazarotene 0.1% gel alone in nail psoriasis was in favor the combination in a significantly superior manner. 81
Antenatal stero >Celestoderm ) can cross the placenta to mature the fetal lung and brain. 142 In the lung, antenatal steroids can decrease the fetal lung fluid through activation of ENaCs, induce the production of surfactant proteins and lipid synthesis, and alter preterm responses to oxidative stress. 142,143 Randomized trials have demonstrated that administration of antenatal corticosteroids significantly reduces the incidences of RDS, neonatal death, cerebral hemorrhage, and NEC. 84 Guidelines recommend the routine use of antenatal steroids for mothers at risk for preterm delivery from 24 weeks to 34 weeks GA. 144 Celestoderm (two doses 24 hours apart), rather than dexamethasone (four doses 12 hours apart), is preferred. Antenatal steroids can be considered at 23 weeks GA but are not currently recommended at 22 weeks GA. 144 Studies have also demonstrated decreased respiratory complications in late preterm infants (34–36 weeks) randomized to antenatal corticosteroids, and revisions to ACOG guidelines are underway. 87,142 Studies of antenatal steroids prior to elective C-section also demonstrate some benefit on respiratory symptoms at birth. 145 The benefit of steroids is maximal in infants delivered between 24 and 168 hours after maternal therapy, but benefits on the lungs are seen in less than 24 hours. 119 The use of repetitive courses of antenatal steroids showed some benefits for respiratory outcomes, but more than five weekly courses caused decreased fetal growth and head circumference. 142 Infants who received repetitive dosing did not show differences in adverse neurologic outcomes at 18-month follow-up. Some obstetricians will give an additional dose of steroids to a mother with persistent threat of preterm delivery 1–2 weeks after initial course. Antenatal steroids do not increase the risk of infection in pregnancies complicated by preterm prelabor rupture of the membranes. There is not a consensus opinion about the use of antenatal steroids for infants of mothers with possible chorioamnionitis.
Thyroid hormones induce surfactant synthesis in animal models. Randomized trials of antenatal administration of thyrotropin-releasing hormone (the only component of the pathway that crosses the placenta) did not reduce the risk of neonatal respiratory distress or BPD, and unfortunately increased the risk of lower 5-minute Apgar scores and caused transient suppression of the pituitary system. 146 Other drugs such as aminophylline, ambroxol, and terbutaline have also been tried, with variable success.
Missed Dose of Celestoderm
If you miss applying Celestoderm topical, try to use it as soon as you remember.
If it's almost time for the next dose, skip the missed dose and use your next dose at the regular time. Do not use two applications of the medication at the same time.
By Frieda Wiley, PharmD, CGP, RPh | Medically Reviewed by Robert Jasmer, MD
Latest Update: 2015-03-09 Copyright © 2014 Everyday Health Media, LLC
Celestoderm S >
The most common side effect from Celestoderm topical is stinging. Other side effects include:
- Burning, itching, or dryness of the skin
- Red bumps around the mouth
- Extremely thick hair growth on unusual areas of the body
- Skin lightening or loss of natural skin color
- Thinning of the skin
- Stretch marks
What are the uses for Celestoderm dipropionate?
Celestoderm is used for the relief of itching and inflammation associated with a wide variety of skin conditions in patients 13 years of age or older. Examples include allergic dermatitis, atopic dermatitis, contact dermatitis, and plaque psoriasis.
If you experience any other symptoms which you think may be due to Celestoderm, speak with your doctor or pharmacist for further advice.
The following local adverse reactions are reported infrequently when Celestoderm Dipropionate Lotion, USP 0.05% w/w is used as recommended in the DOSAGE AND ADMINISTRATION section. These reactions are listed in an approximate decreasing order of occurrence: burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infections, skin atrophy, striae and miliaria.
Adverse reactions reported to be possibly or probably related to treatment with Celestoderm Dipropionate Lotion, USP 0.05% w/w during a pediatric study include: paresthesia (burning), erythema, erythematous rash, and dry skin. These adverse reactions each occurred in a different patient; 4% of the 25 patient population, respectively. An adverse reaction reported to be possibly or probably related to treatment in 2 different patients, 8%, of the 25 patients is puritis.
Systemic absorption of topical corticosteroids has produced reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing's syndrome, hyperglycemia and glucosuria in some patients.