Celestana cream

Celestana

  • Active Ingredient: Betamethasone
  • 20gm
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What is Celestana?

The active ingredient of Celestana brand is betamethasone. The originating document has been archived. We cannot confirm the completeness, accuracy and currency of the content. It is a white to creamy-white, odorless powder insoluble in water; freely soluble in acetone and in chloroform; sparingly soluble in alcohol. Each gram of Betamethasone Dipropionate Lotion USP (Augmented), 0.05% contains: 0.643 mg Betamethasone dipropionate, USP (equivalent to 0.5 mg Betamethasone) in a colorless, clear to translucent lotion base of purified water, isopropyl alcohol (30%), phosphoric acid used to adjust the pH, hydroxypropyl cellulose, propylene glycol, and monobasic sodium phosphate (monohydrate).

Used for

Celestana is used to treat diseases such as: Bursitis, Dermatological Disorders, Gouty Arthritis, Inflammatory Conditions, Osteoarthritis.

Side Effect

Possible side effects of Celestana include: ; ; ; ; ; ; .

How to Buy Celestana cream online?

To purchase Celestana online - simply click on the "Buy Now" button from the top and follow along with our store. Order and payment takes a few minutes, and all steps are evident. We don't take a medical prescription and we have many procedures of payment. Considering each detail of rapid shipping and confidentiality, then you can read on the relevant pages on the links in the navigation menu.

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DOSAGE AND ADMINISTRATION

Apply a few drops of Celestana Dipropionate Lotion to the affected areas and massage lightly until it disappears. Apply twice daily, in the morning and at night. For the most effective and economical use, apply nozzle very close to affected area and gently squeeze bottle.

Celestana Dipropionate Lotion, USP 0.05% w/w is not to be used with occlusive dressings.

What Is Celestana Topical?

Celestana is a steroid that prevents the release of substances in the body that cause inflammation.

Celestana topical (for the skin) is used to treat the inflammation and itching caused by a number of skin conditions such as eczema or psoriasis.

Celestana topical may also be used for purposes not listed in this medication guide.

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

You should not use Celestana topical if you are allergic to it.

Tell your doctor if you have ever had:

  • liver disease;
  • diabetes; or
  • any type of skin infection.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.

It may not be safe to breast-feed a baby while you are using this medicine. Ask your doctor about any risks.

Do not use Celestana topical on a child without a doctor's advice. Children can absorb larger amounts of this medicine through the skin and may be more likely to have side effects.

Diprolene is not approved for use by anyone younger than 13 years old. Sernivo and Luxiq are not approved for anyone younger than 18 years old.

What Other Drugs Interact with Celestana?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Interactions of Celestana include:

  • aminoglutethimide
  • amphotericin B injection and potassium-depleting agents
  • antibiotics, specifically macrolide
  • anticholinesterases
  • oral anticoagulants
  • antidiabetics
  • antitubercular drugs
  • cholestyramine
  • cyclosporine
  • digitalis glycosides
  • estrogens, including oral contraceptives
  • hepatic enzyme inducers (barbituarates, phenytoin, carbamazepine, rifampin)
  • ketoconazole
  • nonsteroidal anti-inflammatory agents (NSAIDs)
  • diminished response to vaccines

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.

Can Celestana cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. You can reduce the risk of side-effects from Celestana by applying the preparation thinly, no more than twice a day, and applying it to the affected areas only.

CLINICAL PHARMACOLOGY

The corticosteroids are a class of compounds comprising steroid hormones, secreted by the adrenal cortex and their synthetic analogs. In pharmacologic doses corticosteroids are used primarily for their anti-inflammatory and/or immunosuppressive effects.

Topical corticosteroids, such as Celestana dipropionate, are effective in the treatment of corticosteroid-responsive dermatoses primarily because of their anti-inflammatory, antipruritic, and vasoconstrictive actions. However, while the physiologic, pharmacologic, and clinical effects of the corticosteroids are well known, the exact mechanisms of their actions in each disease are uncertain. Celestana dipropionate, a corticosteroid, has been shown to have topical (dermatologic) and systemic pharmacologic and metabolic effects characteristic of this class of drugs.

What are some other side effects of Celestana Injection?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Upset stomach or throwing up.
  • Weight gain.
  • Restlessness.
  • Sweating a lot.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

Celestana and Alcohol

Both alcohol and Celestana topical can dry the skin, and the combination may dry the skin even more.

You should avoid or limit drinking alcohol while taking Celestana topical.

Carcinogenesis, Mutagenesis, Impairment of Fertility

Long-term animal studies have not been performed to evaluate the carcinogenic potential of Celestana dipropionate.

Celestana was negative in the bacterial mutagenicity assay ( Salmonella typhimurium and Escherichia coli ), and in the mammalian cell mutagenicity assay (CHO/HGPRT). It was positive in the in-vitro human lymphocyte chromosome aberration assay, and equivocal in the in-vivo mouse bone marrow micronucleus assay. This pattern of response is similar to that of dexamethasone and hydrocortisone.

Reproductive studies with Celestana dipropionate carried out in rabbits at doses of 1.0 mg/kg by the intramuscular route and in mice up to 33 mg/kg by the intramuscular route indicated no impairment of fertility except for dose-related increases in fetal resorption rates in both species. These doses are approximately 0.5 and 4 fold the estimated maximum human dose based on a mg/m 2 comparison, respectively.

Missed Dose of Celestana

If you miss applying Celestana topical, try to use it as soon as you remember.

If it's almost time for the next dose, skip the missed dose and use your next dose at the regular time. Do not use two applications of the medication at the same time.

By Frieda Wiley, PharmD, CGP, RPh | Medically Reviewed by Robert Jasmer, MD

Latest Update: 2015-03-09 Copyright © 2014 Everyday Health Media, LLC

Celestana

An equal mixture of two Celestana salts, Celestone Soluspan, allows for both immediate and delayed corticosteroid responses. Celestana sodium phosphate acts within hours, whereas Celestana acetate is a suspension that is slowly absorbed over approximately 2 weeks. Celestana (Celestone Soluspan) is approved for intraarticular or soft tissue injection to provide short-term adjuvant therapy in osteoarthritis, tenosynovitis, gouty arthritis, bursitis, epicondylitis, and rheumatoid arthritis. 15 It is also commonly employed in epidural injections. Typical intraarticular doses vary with the size of the joint and range from 0.25 to 2 mL (1.5 mg to 12 mg). Typically epidural injections range from 1 to 3 mL (6 to 18 mg). Celestana should not be mixed with local anesthetics that contain preservatives such as methylparaben as these may cause flocculation of the steroid.

Celestana acetate and sodium phosphate

Pharmacologic class: Glucocorticoid (inhalation)

Therapeutic class: Antiasthmatic, antiinflammatory (steroidal)

Pregnancy risk category C

Pharmacokinetics

The extent of percutaneous absorption of topical corticostero >DOSAGE AND ADMINISTRATION ).

Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Corticosteroids are bound to plasma proteins in varying degrees. Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.

Twenty-five pediatric patients ages 6 to 12 years, with atopic dermatitis, were enrolled in an open-label, hypothalamic-pituitary-adrenal (HPA) axis safety study. Celestana Dipropionate Lotion, USP 0.05% w/w was applied twice daily for 2 to 3 weeks over a mean body surface area of 45% (range 35% to 72%). In 11 of 15 (73%) evaluable patients, adrenal suppression was indicated by either a ≤ 5 mcg/dL pre-stimulation cortisol, or a cosyntropin post-stimulation cortisol ≤ 18 mcg/dL and an increase of DOSAGE AND ADMINISTRATION )

Therefore, patients receiving a large dose of a potent topical steroid applied to a large surface area should be evaluated periodically for evidence of HPA axis suppression by using the urinary-free cortisol and ACTH stimulation tests. If HPA axis suppression is noted, an attempt should be made to withdraw the drug, to reduce the frequency of application, or to substitute a less potent steroid.

Recovery of HPA axis function is generally prompt and complete upon discontinuation of the drug. In an open-label pediatric study of 15 evaluable patients, of the 11 subjects who showed evidence of suppression, 6 subjects were tested 2 weeks after discontinuation of Celestana Dipropionate Lotion, USP 0.05% w/w, and 4 of the 6 (67%) had complete recovery of HPA axis function. Infrequently, signs and symptoms of steroid withdrawal may occur, requiring supplemental systemic corticosteroids.

Pediatric patients may absorb proportionally larger amounts of topical corticostero >PRECAUTIONS - Pediatric Use .)

If irritation develops, topical corticosteroids should be discontinued and appropriate therapy instituted.

In the presence of dermatological infections, the use of an appropriate antifungal or antibacterial agent should be instituted. If a favorable response does not occur promptly, the corticosteroid should be discontinued until the infection has been adequately controlled.

Warnings

This medication contains Celestana. Do not take Celestone, Celestone Soluspan, Betaject, or Celestana Intramuscular/Oral if you are allergic to Celestana or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Pediatric Use

Use of Celestana Dipropionate Lotion, USP 0.05% w/w in pediatric patients 12 years of age and younger is not recommended. (See CLINICAL PHARMACOLOGY and ADVERSE REACTIONS Sections.) In an open-label study, 11 of 15 (73%) evaluable pediatric patients (aged 6 years-12 years old) using Celestana Dipropionate Lotion, USP 0.05% w/w for treatment of atopic dermatitis for 2-3 weeks demonstrated adrenal suppression. (See CLINICAL PHARMACOLOGY - Pharmacokinetics .)

Pediatric patients may demonstrate greater susceptibility to topical corticosteroid-induced HPA axis suppression and Cushing's syndrome than mature patients because of a larger skin surface area to body weight ratio.

Hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing's syndrome, and intracranial hypertension have been reported in pediatric patients receiving topical corticosteroids. Manifestations of adrenal suppression in pediatric patients include linear growth retardation, delayed weight gain, low plasma cortisol levels, and absence of response to ACTH stimulation. Manifestations of intracranial hypertension include bulging fontanelles, headaches, and bilateral papilledema.

Administration of topical corticosteroids to pediatric patients should be limited to the least amount compatible with an effective therapeutic regimen. Chronic corticosteroid therapy may interfere with the growth and development of pediatric patients.


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