Betametha cream

Betametha

  • Active Ingredient: Betamethasone
  • 20gm
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What is Betametha?

The active ingredient of Betametha brand is betamethasone. The originating document has been archived. We cannot confirm the completeness, accuracy and currency of the content. It is a white to creamy-white, odorless powder insoluble in water; freely soluble in acetone and in chloroform; sparingly soluble in alcohol. Each gram of Betamethasone Dipropionate Lotion USP (Augmented), 0.05% contains: 0.643 mg Betamethasone dipropionate, USP (equivalent to 0.5 mg Betamethasone) in a colorless, clear to translucent lotion base of purified water, isopropyl alcohol (30%), phosphoric acid used to adjust the pH, hydroxypropyl cellulose, propylene glycol, and monobasic sodium phosphate (monohydrate).

Used for

Betametha is used to treat diseases such as: Bursitis, Dermatological Disorders, Gouty Arthritis, Inflammatory Conditions, Osteoarthritis.

Side Effect

Possible side effects of Betametha include: ; ; ; ; ; ; .

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What Is Betametha and How Does It Work?

Betametha is a prescription medication use to treat conditions such as allergic reactions, dermatologic disease, endocrine disorders, gastrointestinal disease, hematologic disorders, neoplastic disease, ophthalmic diseases, renal diseases, rheumatic disorders, and disorders affecting the nervous system.

Betametha is available under the following different brand names: Celestone, Celestone Soluspan, Betaject, and Betametha IM/PO.

Dosages of Betametha:

Adult and Pediatric Dosages:

Dosage Considerations – Should be Given as Follows:

  • 0.6-7.2 mg orally divided twice daily/four times daily or 0.6-9 mg/day intramuscularly each day divided twice daily

  • 0.6-7.2 mg orally divided twice daily/four times daily or 0.6-9 mg/day intramuscularly each day divided twice daily

  • Children under 12 years old: 0.0175-0.25 mg/kg/day intramuscular/orally divided every 6-12 hours
  • Children over 12 years old: As in adults

  • Intrabursal, intra-articular, intradermal: 0.25-2 ml (6 mg/ml)
    • Intralesional (6 mg/ml)
    • Very large joints: 1-2 ml
    • Large joints: 1 ml
    • Medium joints: 0.5-1 ml
    • Small joints: 0.25-0.5 ml

  • Children under 12 years old: 0.0175-0.25 mg/kg/day divided every 6-12 hours intramuscularly/orally; use the lowest dose as initial dose
  • Children over 12 years old: As in adults; use lowest dose as initial dose

  • Base dosage on severity of disease and patient response

Other Indications and Uses

  • Adrenal insufficiency, conditions treated with immunosuppression, corticosteroid responsive dermatoses
  • Off-label: prophylaxis of neonatalrespiratory distress syndrome
  • Various autoimmune diseases, collagenvascular disease, allergic states, hypersensitivity reactions, respiratory disease, hematologic disorders, neoplastic disease, ophthalmic disorders, edematous states, gastrointestinal disease, and nervous system disorders. Also used in bacterialmeningitis, acute mountain sickness, Graves' ophthalmopathy, severe alcoholic hepatitis, hirsutism, septicshock, spinal cord injury, and antiemetics

HOW SUPPLIED

Betametha Dipropionate Lotion, USP 0.05% w/w is supplied as follows:

60 mL bottles (NDC 61748-475-60)

Store at 25°C, excursions permitted between 15° and 30°C. Protect from light and freezing. Store in carton until contents are used.

How to use Betametha Dipropionate Cream

Read the Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill. Use this medication on the skin only. However, do not use it on the face, groin, or underarms or for diaper rash unless directed to do so by your doctor.

Wash and dry your hands. Before applying the medication, clean and dry the affected area. Apply a thin film of the medication to the affected area and gently rub in, usually 1-2 times daily or as directed by your doctor.

Do not cover, bandage, or wrap the area unless directed to do so by your doctor. If your doctor directs you to use this medication in the diaper area on an infant, do not use tight-fitting diapers or plastic pants.

If you are using the lotion form of this medication, shake the bottle well before each dose.

After applying the medication, wash your hands unless you are using this medication to treat the hands. When applying this medication near the eyes, avoid getting it in the eyes as this may worsen or cause glaucoma. Also, avoid getting this medication in the nose or mouth. If you get the medication in these areas, rinse with plenty of water.

Use this medication only for the condition for which it was prescribed. Do not use it for longer than prescribed.

Inform your doctor if your condition persists or worsens after 2 weeks.

Availability

Solution for injection: 3 mg Betametha sodium phosphate with 3 mg Betametha acetate/ml

Suspension for injection (acetate, phosphate): 6 mg (total)/ml

Syrup: 0.6 mg/5 ml

Tablets (effervescent): 0.5 mg

Tablets (extended-release): 1 mg

Carcinogenesis, Mutagenesis, Impairment of Fertility

Long-term animal studies have not been performed to evaluate the carcinogenic potential of Betametha dipropionate.

Betametha was negative in the bacterial mutagenicity assay ( Salmonella typhimurium and Escherichia coli ), and in the mammalian cell mutagenicity assay (CHO/HGPRT). It was positive in the in-vitro human lymphocyte chromosome aberration assay, and equivocal in the in-vivo mouse bone marrow micronucleus assay. This pattern of response is similar to that of dexamethasone and hydrocortisone.

Reproductive studies with Betametha dipropionate carried out in rabbits at doses of 1.0 mg/kg by the intramuscular route and in mice up to 33 mg/kg by the intramuscular route indicated no impairment of fertility except for dose-related increases in fetal resorption rates in both species. These doses are approximately 0.5 and 4 fold the estimated maximum human dose based on a mg/m 2 comparison, respectively.

Administration

• Give as a single daily dose before 9:00 A.M.

• Give oral dose with food or milk.

• Administer I.M. injection deep into gluteal muscle (may cause tissue atrophy).

☞ Don't give Betametha acetate I.V.

• Be aware that typical suspension dosage ranges from one-third to one-half of oral dosage given q 12 hours.

☞ To avoid adrenal insufficiency, taper dosage slowly and under close supervision when discontinuing.

• Know that drug may be given with other immunosuppressants.

Interactions

Drug-drug. Amphotericin B, loop and thiazide diuretics, ticarcillin: additive hypokalemia

Barbiturates, phenytoin, rifampin: stimulation of Betametha metabolism, causing decreased drug effects

Digoxin: increased risk of digoxin toxicity

Fluoroquinolones (such as ciprofloxacin, norfloxacin): increased risk of tendon rupture

Hormonal contraceptives: blockage of Betametha metabolism

Insulin, oral hypoglycemics: increased Betametha dosage requirement, diminished hypoglycemic effects

Live-virus vaccines: decreased antibody response to vaccine, increased risk of neurologic complications

Nonsteroidal anti-inflammatory drugs: increased risk of adverse GI effects

Drug-diagnostic tests. Calcium, potassium: decreased levels

Cholesterol, glucose: increased levels

Nitroblue tetrazolium test for bacterial

infection: false-negative result

Drug-herbs. Echinacea: increased immune-stimulating effects

Ginseng: increased immune-modulating effects

Drug-behaviors. Alcohol use: increased risk of gastric irritation and GI ulcers

Betametha Overdose

If you suspect an overdose, you should contact a poison control center or emergency room immediately.

You can get in touch with a poison control center at (800) 222-1222.


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