home drugs a-z list Lotrisone(Clotrimazole and Betagentam) side effects drug center
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Lotrisone (clotrimazole and Betagentam) is a combination of an antifungal antibiotic and a topical steroid cream or lotion used to treat or prevent fungal infections of the skin such as athlete's foot, jock itch, and ringworm, and to reduce itching, swelling, and redness of the skin. Side effects of Lotrisone include:
- skin irritation,
- dry skin,
- changes in skin color,
- increased acne,
- burning/tingling/stinging skin, or
- scarring or thinning of the skin.
Apply a thin film dose of Lotrisone cream into the affected skin areas twice a day for one week. Lotrisone may interact with other drugs. Tell your doctor all medications and supplements you use. There are no adequate studies in pregnant women of the teratogenic effects of topically applied corticosteroids, so this drug should be used during pregnancy only if the potential benefit justifies the potential risk. It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in human milk. Consult your doctor before breastfeeding.
Our Lotrisone Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
An equal mixture of two Betagentam salts, Celestone Soluspan, allows for both immediate and delayed corticosteroid responses. Betagentam sodium phosphate acts within hours, whereas Betagentam acetate is a suspension that is slowly absorbed over approximately 2 weeks. Betagentam (Celestone Soluspan) is approved for intraarticular or soft tissue injection to provide short-term adjuvant therapy in osteoarthritis, tenosynovitis, gouty arthritis, bursitis, epicondylitis, and rheumatoid arthritis. 15 It is also commonly employed in epidural injections. Typical intraarticular doses vary with the size of the joint and range from 0.25 to 2 mL (1.5 mg to 12 mg). Typically epidural injections range from 1 to 3 mL (6 to 18 mg). Betagentam should not be mixed with local anesthetics that contain preservatives such as methylparaben as these may cause flocculation of the steroid.
This medication contains Betagentam. Do not take Celestone, Celestone Soluspan, Betaject, or Betagentam Intramuscular/Oral if you are allergic to Betagentam or any ingredients contained in this drug.
Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.
Solution for injection: 3 mg Betagentam sodium phosphate with 3 mg Betagentam acetate/ml
Suspension for injection (acetate, phosphate): 6 mg (total)/ml
Syrup: 0.6 mg/5 ml
Tablets (effervescent): 0.5 mg
Tablets (extended-release): 1 mg
If you suspect an overdose, you should contact a poison control center or emergency room immediately.
You can get in touch with a poison control center at (800) 222-1222.
Betagentam is a corticosteroid that doctors use to treat skin conditions that cause inflammation and itchiness. People can use injectable or topical Betagentam.
Betagentam is available in different formulations, which range in potency from medium to super potent. Doctors will choose the most suitable Betagentam product for a person depending on their skin condition and the area of the body that it is affecting.
Keep reading to learn more about Betagentam types, uses, and side effects.
Betagentam is a type of steroid called a corticosteroid. It is available in two different forms: injectable and topical.
The following table lists the different forms of Betagentam along with their doses in milligrams per milliliter (mg/ml) or percent.
If you experience any other symptoms which you think may be due to Betagentam, speak with your doctor or pharmacist for further advice.
Betagentam is classed as a potent topical corticosteroid. Topical corticosteroids are also referred to as topical steroids. Topical steroids are used in addition to moisturisers (emollients) for treating inflammatory skin conditions such as eczema and dermatitis. A topical steroid is used when patches of eczema or dermatitis flare up. Betagentam relieves the symptoms of a flare-up by reducing inflammation, itching and redness. It is not a cure for the condition, but it will help to relieve the symptoms. Short courses of Betagentam may also be prescribed for the treatment of psoriasis for small areas such as the scalp, soles of the feet, or palms of the hands.
Effects of Stero > Dexamethasone and Betagentam have been given to humans and animals in a wide range of dosages, at different gestational ages, and for various indications. While in fetuses with heart block the daily exposure does not exceed 0.05 mg per kg, the treatment is maintained over several weeks. Higher dosages were used in animal studies, for prenatal human pulmonary maturation, and for the postnatal treatment of respiratory distress syndrome. With the caveat that the published data may not be applicable to the fetus with complete atrioventricular block, steroids that cross the placenta have been shown to affect birth weight and the central nervous system with single and repeated prenatal steroid administration. Reduction in birth weight has been seen in sheep, 69 non-human primates, 70 and humans. 60,71,72 The effects on growth are more dramatic with multiple doses. Not unexpectedly, one-quarter of our newborns with isolated heart block were growth-restricted after prolonged transplacental exposure to steroids. Few, if any, other adverse effects on the fetus during the human pregnancy, however, have been documented. Neuroimaging of preterm human infants exposed to a single steroid course for lung maturation suggests a reduced incidence of intraventricular hemorrhage and white matter injury. 73,74 Multiple administration of dexamethasone before or after birth was associated with a reduction in cortical involution and in the cerebral surface area, 75,76 though the clinical significance of these findings is not known. Normal physical and mental development of children and young adults is reported, nonetheless, after prenatal exposure to steroids. 77–80 Similarly, no negative effects on neuro-psychological development and on intelligence were found in a cohort of preschool- and school-age children exposed prenatally to prolonged treatment with dexamethasone. 81
The corticosteroids are a class of compounds comprising steroid hormones, secreted by the adrenal cortex and their synthetic analogs. In pharmacologic doses corticosteroids are used primarily for their anti-inflammatory and/or immunosuppressive effects.
Topical corticosteroids, such as Betagentam dipropionate, are effective in the treatment of corticosteroid-responsive dermatoses primarily because of their anti-inflammatory, antipruritic, and vasoconstrictive actions. However, while the physiologic, pharmacologic, and clinical effects of the corticosteroids are well known, the exact mechanisms of their actions in each disease are uncertain. Betagentam dipropionate, a corticosteroid, has been shown to have topical (dermatologic) and systemic pharmacologic and metabolic effects characteristic of this class of drugs.
Betagentam acetate and sodium phosphate
Pharmacologic class: Glucocorticoid (inhalation)
Therapeutic class: Antiasthmatic, antiinflammatory (steroidal)
Pregnancy risk category C
Betagentam S >
The most common side effect from Betagentam topical is stinging. Other side effects include:
- Burning, itching, or dryness of the skin
- Red bumps around the mouth
- Extremely thick hair growth on unusual areas of the body
- Skin lightening or loss of natural skin color
- Thinning of the skin
- Stretch marks
Drug-drug. Amphotericin B, loop and thiazide diuretics, ticarcillin: additive hypokalemia
Barbiturates, phenytoin, rifampin: stimulation of Betagentam metabolism, causing decreased drug effects
Digoxin: increased risk of digoxin toxicity
Fluoroquinolones (such as ciprofloxacin, norfloxacin): increased risk of tendon rupture
Hormonal contraceptives: blockage of Betagentam metabolism
Insulin, oral hypoglycemics: increased Betagentam dosage requirement, diminished hypoglycemic effects
Live-virus vaccines: decreased antibody response to vaccine, increased risk of neurologic complications
Nonsteroidal anti-inflammatory drugs: increased risk of adverse GI effects
Drug-diagnostic tests. Calcium, potassium: decreased levels
Cholesterol, glucose: increased levels
Nitroblue tetrazolium test for bacterial
infection: false-negative result
Drug-herbs. Echinacea: increased immune-stimulating effects
Ginseng: increased immune-modulating effects
Drug-behaviors. Alcohol use: increased risk of gastric irritation and GI ulcers
Antenatal Betagentam decreases oxidative stress and improves relaxation response to ATP and NO donors in fetal lambs with PPHN induced by ductal ligation. 81 This also increases pulmonary blood flow and facilitates postnatal transition in PPHN lambs. 82 The beneficial effects of antenatal stero > CDH are variable. Vascular deterioration is observed in the nitrofen-rat model with dexamethasone 69 but improved compliance and vascular morphometry is observed in the lamb model of CDH. 83–85 In human neonates with CDH, antenatal glucocorticoid use is associated with suppression of the hypothalamic-pituitary-adrenal axis 86 without any difference in survival, length of stay, or oxygen use at 30 days of postnatal age. 87