Urispadol tablets


  • Active Ingredient: Flavoxate
  • 200 mg
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What is Urispadol?

The active ingredient of Urispadol brand is flavoxate. Flavoxate reduces muscle spasms of the bladder and urinary tract. Each tablet for oral administration contains 100 mg Flavoxate hydrochloride. In addition, each tablet contains the following inactive ingredients: colloidal silicon dioxide, corn starch, dibasic calcium phosphate dihydrate, magnesium stearate, hypromellose, polydextrose, polyethylene glycol, titanium dioxide and triacetin.

Used for

Urispadol is used to treat diseases such as: Dysuria, Overactive Bladder, Urinary Incontinence.

Side Effect

Possible side effects of Urispadol include: dizziness (severe); hallucinations (seeing, hearing, or feeling things that are not there); sore throat and fever; Clumsiness or unsteadiness; drowsiness (severe); difficult urination; headache.

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Where can I get more information?

Your pharmacist can provide more information about Urispadol.

What is the most important information I should know about Urispadol (Urispas)?

You should not use Urispadol if you have bleeding or a blockage in your digestive tract (stomach or intestines), a bladder obstruction, or if you are unable to urinate.

Urispadol side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Common side effects may include:

pounding heartbeats or fluttering in your chest;

confusion, nervousness; or

rash or itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I take Urispadol (Urispas)?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Your doctor may occasionally change your Urispadol dose to make sure you get the best results.

Call your doctor if your symptoms do not improve, or if they get worse.

If your doctor has also prescribed medicine to treat a bladder infection, use that medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics.

Store Urispadol at room temperature away from moisture, heat, and light.


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Pharmacology and toxicology

Atropine, a belladonna-alkaloid, is a classic parasympatholytic, which inhibits the action of acetylcholine by competitively blocking muscarine receptors. With local application (in the eye), systemic availability is negligible when applied properly. l-Atropine is the biologically active enantiomer, and is sometimes encountered under the name hyoscyamine.

Atropine reaches concentrations in the fetus equivalent to those in the mother within a few minutes. Although atropine may alter fetal heart rate or inhibit fetal breathing after systemic application, exposure to this drug during pregnancy has not been associated with adverse developmental effects or significant fetotoxicity at recommended therapeutic dosages.

Atropine-like belladonna-alkaloids and their derivatives are parasympathicolytic agents, used in the relief of visceral spasms of the gastrointestinal tract and of colic of the biliary and genitourinary systems; some of these agents are used in the treatment of peptic ulcer. Mydriasis (for diagnostical purpose), respiratory tract disorders, urinary incontinence and Parkinsonism are other indications.

Atropine-like belladonna alkalo >Urispadol , oxybutynin, tolterodine, cyclopentolate, and tropicam > It is also available as a mydriatic, and as a patch for prevention of motion sickness (see Chapter 2.4 ). Homatropine, cyclopentolate, and tropicamide are available as a mydriatic.

Urispadol, oxybutynin, and tolterodine are smooth-muscle relaxants for the urinary tract or bladder.

The quaternary ammonium derivatives of atropine-like belladonna alkaloids have peripheral effects similar to those of atropine; central (CNS) effects are negligible. With systemic application, peripheral effects similar to those of atropine cannot be ruled out. The quaternary ammonium derivatives are mostly used as spasmolytics and for gastrointestinal disorders. Among them, butylscopolamine is the most widely used spasmolytic. Butylscopolamine is poorly absorbed after oral administration. Two cases of eclamptic seizures after the intravenous administration of butylscopolamine in patients with severe pre-eclampsia were reported ( Kobayashi 2002 ).

Others are clidinium, glycopyrronium, methantheline, methylscopolamine, pipenzolate, pipoxolan, propantheline, and trospium chloride.

There are no detailed studies in humans concerning the use of these anticholinergic drugs during pregnancy. The same applies to the antispasmodics denaverin, hymecromon, mebeverine, papaverine, phenamazide, pinaverium, and tiropramide.

Specific embryotoxic effects in humans have not thus far been observed with the use of the belladonna alkaloids and derivatives mentioned, but documented experience is very limited.

Diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), and as such a prostaglandin synthetase inhibitor, is used as a spasmolytic in the relief of kidney and biliary colic (see Chapter 2.1 ).

Anticholinergics, including atropine, can be used throughout pregnancy when strongly indicated. Functional effects, i.e. on the fetal heart rate, must be considered with systemic use. Butylscopolamine is the spasmolytic of choice in this group of medications. Diagnostic application of anticholinergics in the eye can be undertaken during pregnancy. Diarrhea should not be treated routinely with anticholinergics.


URISPASĀ® (Urispadol HC1) is indicated for symptomatic relief of dysuria, urgency, nocturia, suprapubic pain, frequency and incontinence as may occur in cystitis, prostatitis, urethritis, urethrocystitis/urethrotrigonitis. URISPASĀ® is not indicated for definitive treatment, but is compatible with drugs used for the treatment of urinary tract infections.

What Is Urispadol?

Urispadol reduces muscle spasms of the bladder and urinary tract.

Urispadol is used to treat bladder symptoms such as painful urination, frequent or urgent urination, increased night-time urination, bladder pain, and incontinence (urine leakage). These bladder symptoms are often caused by overactive bladder, prostate enlargement, bladder infections, or irritation of the urethra.

Urispadol will not treat a bladder infection. Infections must be treated with an antibiotic.

Urispadol may also be used for purposes not listed in this medication guide.

You should not use Urispadol if you have bleeding or a blockage in your digestive tract (stomach or intestines), a bladder obstruction, or if you are unable to urinate.

You should not use Urispadol if you are allergic to it, or if you have:

  • blockage in your digestive tract (stomach or intestines);
  • stomach or intestinal bleeding; or
  • bladder obstruction or if you are unable to urinate.

To make sure Urispadol is safe for you, tell your doctor if you have:

This medicine is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether Urispadol passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Urispadol is not approved for use by anyone younger than 12 years old.

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These symptoms can cause you distress as well as being a hygiene problem. There are several causes of urinary incontinence, including weakened pelvic floor muscles and problems causing your bladder muscles to go into spasm as a result of a medical procedure.

Urispadol works by stopping sudden bladder muscle contractions and increasing the volume of urine that your bladder can hold. This helps to control urinary symptoms and eases any pain or discomfort.

What other drugs will affect Urispadol?

Other drugs may interact with Urispadol, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information (Urispas)?

Your pharmacist can provide more information about Urispadol.

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