Tonaril tablets


  • Active Ingredient: Trihexyphenidyl
  • 2 mg
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What is Tonaril?

The active ingredient of Tonaril brand is trihexyphenidyl. Trihexyphenidyl alters unusual nerve impulses and relaxes stiff muscles.

Used for

Tonaril is used to treat diseases such as: Cerebral Spasticity, Extrapyramidal Reaction, Parkinson's Disease.

Side Effect

Possible side effects of Tonaril include: constipation; swollen, painful, or tender lymph glands on the side of the face or neck; decrease in urine volume; hyperventilation; shaking; mental confusion; stomach pain; decrease in frequency of urination.

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Tonaril (Artane) 1 to 100 mg per day, divided, three to four times a day

Baclofen (Lioresal) 10 to 80 mg per day, divided, three times a day

Diazepam (Valium) 2 to 10 mg per day, divided, two to three times a day

Tizanidine (Zanaflex) 8 to 24 mg per day, divided, three times a day

Carbamazepine (Tegretol) 300 to 1200 mg per day, divided, three to four times a day

Botulinum toxin (Botox) injected into selected muscles several times per year

Warnings for people with certain health conditions

For people with open-angle glaucoma: You should not use Tonaril if you have open-angle glaucoma because it may cause blindness. Your doctor should do an eye exam before starting you on this drug to make sure your eye sight is okay.

For people with liver disease: If you have liver disease, your body may not be able to process this drug well. This can cause an increase in the levels of this drug in your body. This can raise your risk of side effects.

For people with heart disease: If you have heart disease, you may be at an increased risk for angina (chest pain) or tachycardia (a fast heart rate). Your doctor may want to monitor you more closely for side effects and start you on a lowered dosage to see how you respond.

For people with kidney disease: If you have kidney problems or a history of kidney disease, you may not be able to clear this drug from your body well. This may increase the levels of this drug in your body and cause more side effects. Your doctor may monitor you more closely for side effects.

For people with high blood pressure: You may be at increased risk for angina (chest pain), a heart attack, or tachycardia (a fast heart rate). Your doctor may monitor you more closely for side effects and start you on a lower dosage to see how you respond.

For people with arteriosclerosis: If you have hardening of the walls of your arteries, your sensitivity to this drug may be increased. This can cause mental confusion, irritability, behavior changes, nausea, and vomiting. To avoid these symptoms, your doctor may start you at a low dosage and slowly increase it.

All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What is Tonaril?

Tonaril alters unusual nerve impulses and relaxes stiff muscles.

Tonaril is used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease. It is also used to treat and prevent the same muscular conditions when they are caused by drugs such as chlorpromazine (Thorazine), fluphenazine (Prolixin), perphenazine (Trilafon), haloperidol (Haldol), thiothixene (Navane), and others.

Tonaril may also be used for purposes other than those listed in this medication guide.

More common side effects

Some of the more common side effects that can occur with use of Tonaril include:

  • dry mouth
  • blurred vision
  • dizziness
  • nausea
  • nervousness
  • constipation
  • drowsiness
  • trouble urinating

In addition to the side effects listed above, the following have been reported in children who have used this drug:

  • forgetfulness
  • weight loss
  • restlessness
  • trouble sleeping
  • muscle spasms
  • involuntary body movements

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

What should I avo >

Use caution when driving, operating machinery, or performing other hazardous activities. Tonaril may cause dizziness or blurred vision. If you experience dizziness or blurred vision, avoid these activities.

Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking Tonaril.

Avoid becoming overheated. Tonaril may cause decreased sweating. This could lead to heat stroke in hot weather or with vigorous exercise. Try to keep as cool as possible and watch for signs of heat stroke such as decreased sweating, nausea, and dizziness.

Depression drugs

When taken with Tonaril, certain depression drugs can increase the risk of side effects such as dry mouth, trouble urinating, bloating, less sweat, and increased body temperature. Examples of these drugs include:

  • isocarboxazid
  • phenelzine
  • tranylcypromine
  • amitriptyline
  • clomipramine
  • desipramine
  • nortriptyline

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

Do not stop taking Tonaril abruptly Your symptoms may return quickly and you may develop a life-threatening condition called neuroleptic malignant syndrome. Be sure to talk to your doctor before stopping this drug.

This drug comes with several warnings.

Generic Name: Tonaril Tablets (try heks ee FEN i dill)

Medically reviewed by Last updated on Sep 4, 2019.


Tonaril is the only anticholinergic with sufficient evidence supporting its use in dystonia . Its mechanism of action is not completely clear. It is thought that a selective M1 muscarinic receptor antagonism offsets synaptic plasticity deficits in the striatum and provides dystonia relief . Tonaril should be started at a low dose of 1–2 mg daily and weekly titrated to a usual effective dose of 8–10 mg/day. Common side effects are dry mouth, constipation, blurred vision, cognitive impairment, and urinary retention. It is generally well tolerated in younger patients even at high doses, but its use in the elderly, especially in those with cognitive impairment or a history of retentive bladder, should be considered with caution.

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