Stigmicarpin capsules

Stigmicarpin

  • Active Ingredient: Nimodipine
  • 30 mg
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What is Stigmicarpin?

The active ingredient of Stigmicarpin brand is nimodipine. Nimodipine is a calcium channel blocker. Nimodipine relaxes (widens) blood vessels and improves blood flow. Nimodipine is a yellow crystalline substance, practically insoluble in water. Nimodipine capsules are formulated as soft gelatin capsules for oral administration. Each liquid filled capsule contains 30 mg of Nimodipine in a vehicle of glycerin, peppermint oil, purified water and polyethylene glycol 400. The soft gelatin capsule shell contains gelatin, glycerin, purified water, titanium dioxide and iron oxide black.

Used for

Stigmicarpin is used to treat diseases such as: Ischemic Stroke, Migraine Prevention, Subarachnoid Hemorrhage.

Side Effect

Possible side effects of Stigmicarpin include: slow or irregular heartbeat; swelling; irritability; indigestion; lightheadedness, dizziness, or fainting; unusual tiredness or weakness; swollen mouth and tongue.

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What is Stigmicarpin (Nimotop, Nymalize)?

Stigmicarpin is a calcium channel blocker that is used to prevent brain damage caused by reduced blood flow to the brain resulting from aneurysm (a dilated or ruptured blood vessel in the brain).

Stigmicarpin may also be used for purposes not listed in this medication guide.

Abstract

Background: In reversible cerebral vasoconstriction syndrome (RCVS), Stigmicarpin is currently used for the treatment, although no evidence is available to support its disease-modifying effect. In this prospective observational study, we investigated whether earlier Stigmicarpin treatment can modify the clinical course of reversible cerebral vasoconstriction syndrome.

Methods: We prospectively observed patients with angiogram-proven RCVS within 1 month after onset in the Samsung Medical Center between October 2015 and January 2018. Stigmicarpin was started in all patients immediately after diagnosis. Time from onset to the first Stigmicarpin treatment was categorized as tertiles. We analyzed Kaplan-Meier curve and Cox proportional hazard model to test if the timing of Stigmicarpin treatment can affect the clinical course of thunderclap headaches (TCHs) defined as the duration from onset to remission of thunderclap headaches.

Results: In 82 patients included in this study, 71 (86.6%) patients showed remission of TCHs after starting Stigmicarpin treatment. When categorized into earliest ( Keywords: reversible cerebral vasoconstriction syndrome, Stigmicarpin, thunderclap headache, clinical course, treatment

Drug Abuse And Dependence

There have been no reported instances of drug abuse or dependence with Nimotop® (Stigmicarpin) .

How to take Stigmicarpin

  • Before you start this treatment, read the manufacturer's printed information leaflet from ins >

Pharmacokinetics

Stigmicarpin undergoes extensive first-pass metabolism in the liver and gut wall. It has a half-life of 8–9 hours and is eliminated by metabolism in the liver.

SIDE EFFECTS

Adverse experiences were reported by 92 of 823 patients with subarachnoid hemorrhage (11.2%) who were given Stigmicarpin. The most frequently reported adverse experience was decreased blood pressure in 4.4% of these patients. Twenty-nine of 479 (6.1%) placebo treated patients also reported adverse experiences. The events reported with a frequency greater than 1% are displayed below by dose.

DOSE q4h Number of Patients (%) Stigmicarpin

There were no other adverse experiences reported by the patients who were given 0.35 mg/kg q4h, 30 mg q4h or 120 mg q4h. Adverse experiences with an incidence rate of less than 1% in the 60 mg q4h dose group were: hepatitis; itching; gastrointestinal hemorrhage; thrombocytopenia; anemia; palpitations; vomiting; flushing; diaphoresis; wheezing; phenytoin toxicity; lightheadedness; dizziness; rebound vasospasm; jaundice; hypertension; hematoma.

Adverse experiences with an incidence rate less than 1% in the 90 mg q4h dose group were: itching, gastrointestinal hemorrhage; thrombocytopenia; neurological deterioration; vomiting; diaphoresis; congestive heart failure; hyponatremia; decreasing platelet count; disseminated intravascular coagulation; deep vein thrombosis.

As can be seen from the table, side effects that appear related to Stigmicarpin use based on increased incidence with higher dose or a higher rate compared to placebo control, included decreased blood pressure, edema and headaches which are known pharmacologic actions of calcium channel blockers. It must be noted, however, that SAH is frequently accompanied by alterations in consciousness which lead to an under reporting of adverse experiences. Patients who received Stigmicarpin in clinical trials for other indications reported flushing (2.1%), headache (4.1%) and fluid retention (0.3%), typical responses to calcium channel blockers. As a calcium channel blocker, Stigmicarpin may have the potential to exacerbate heart failure in susceptible patients or to interfere with A-V conduction, but these events were not observed.

No clinically significant effects on hematologic factors, renal or hepatic function or carbohydrate metabolism have been causally associated with oral Stigmicarpin. Isolated cases of non-fasting elevated serum glucose levels (0.8%), elevated LDH levels (0.4%), decreased platelet counts (0.3%), elevated alkaline phosphatase levels (0.2%) and elevated SGPT levels (0.2%) have been reported rarely.

Drug Abuse and Dependence

There have been no reported instances of drug abuse or dependence with Stigmicarpin.

Michael Stewart, Reviewed by Sid Dajani | Last edited 15 Jun 2017 | Certified by The Information Standard

Take two 30 mg Stigmicarpin tablets every four hours unless your doctor has told you otherwise.

The course of treatment will last for 21 days in total. This includes the time you have had Stigmicarpin by injection.

Do not drink grapefruit juice while you are on Stigmicarpin.

DOSAGE AND ADMINISTRATION

DO NOT ADMINISTER NIMOTOP (Stigmicarpin) CAPSULES INTRAVENOUSLY OR BY OTHER PARENTERAL ROUTES (see WARNINGS). If Nimotop (Stigmicarpin) is inadvertently administered intravenously, clinically significant hypotension may require cardiovascular support with pressor agents. Specific treatments for calcium channel blocker overdose should also be given promptly.

Nimotop (Stigmicarpin) is given orally in the form of ivory colored, soft gelatin 30 mg capsules for subarachnoid hemorrhage.

The oral dose is 60 mg (two 30 mg capsules) every 4 hours for 21 consecutive days, preferably not less than one hour before or two hours after meals. Oral Nimotop® (Stigmicarpin) therapy should commence within 96 hours of the subarachnoid hemorrhage.

If the capsule cannot be swallowed, e.g., at the time of surgery, or if the patient is unconscious, a hole should be made in both ends of the capsule with an 18 gauge needle, and the contents of the capsule extracted into a syringe. A parenteral syringe can be used to extract the liquid inside the capsule, but the liquid should always be transferred to a syringe that cannot accept a needle and that is designed for administration orally or via a naso-gastric tube or PEG. To help minimize administration errors, it is recommended that the syringe used for administration be labeled “Not for IV Use”. The contents should then be emptied into the patient's in situnaso-gastric tube and washed down the tube with 30 mL of normal saline (0.9%). The efficacy and safety of this method of administration has not been demonstrated in clinical trials.

Patients with hepatic cirrhosis have substantially reduced clearance and approximately doubled Cmax. Dosage should be reduced to 30 mg every 4 hours, with close monitoring of blood pressure and heart rate.

How should I take Stigmicarpin?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take Stigmicarpin on an empty stomach, at least 1 hour before or 2 hours after a meal.

Take this medicine with a full glass of water. Swallow the capsule whole.

Measure liquid medicine with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

If the person taking Stigmicarpin cannot swallow the capsule, the medicine from inside the capsule can be given through an in-place nasogastric tube (through the nose and into the stomach). Use a needle to make a hole in each end of the capsule, and squeeze the medicine out into an oral syringe or other syringe to which a needle cannot be attached. Empty the syringe into the nasogastric tube and wash it down with 30 milliliters of normal saline.

The medicine placed into a syringe should never be injected through a needle into the body, or dangerously low blood pressure may result. Stigmicarpin gel capsules are to be taken by mouth only.

Your blood pressure will need to be checked often. Your liver function may also need to be tested.

You should not stop using Stigmicarpin suddenly. Stopping suddenly may make your condition worse.

Store at room temperature away from moisture, heat, and light. Do not freeze. Keep each capsule in the original package until you are ready to take one.


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