What is Procid?
Procid helps your body pass uric acid out through the urine, which lowers the levels of uric acid in the body.
Procid is used to treat gout and gouty arthritis. Procid is also sometimes given together with penicillin antibiotics to make them more effective.
Procid may also be used for other purposes not listed in this medication guide.
CSF 5-HIAA in Depressives and Controls
While the majority of studies of Procid induced accumulation of CSF 5-HIAA have shown a lower accumulation in depressives than in controls, there is much more conflict about baseline levels. Since the differences, if any, are likely to be smaller when Procid is not used, it is important that the controls are adequately selected, and that the procedure is performed in an identical way in both groups of subjects. This is particularly important, since there is a concentration gradient of 5-HIAA in the CSF ( Gerbode and Bowers, 1968 , Jakupcevic and co-workers, loc.cit.). This means that if a smaller amount of CSF were drawn from patients than from volunteers, a spurious difference in CSF 5-HIAA between the two groups could very easily be demonstrated.
In our studies, we have consistently worked with payed healthy volunteers, recruited among hospital staff and blood donors. It can perhaps be questioned how representative such volunteers may be for the “normal” population. Ongoing studies of their personalities will hopefully tell us more about this. But this selection of volunteers carries with it even more mundane problems: the volunteers tend to be younger, and more often of male sex, than the depressives who are typically middle-aged and elderly women.
Age and sex may both be important for CSF 5-HIAA. Most, but not all investigators report increasing levels in the higher age groups ( Gottfries and co-workers, 1971 , Åsberg and co-workers, 1973 ). In our volunteer material ( Fig. 1 ), the association appears to be curvilinear with a rather steep rise above 50 years, in agreement with the findings of Bowers and Gerbode (1968) for neurological and psychiatric patients.
PRINCIPAL DISPLAY PANEL
NDC 10135-541-01 Procid Tablets, USP 500 mg 100 Tablets Rx Only
What is the most important information I should know about Procid (Benemid)?
You should not use this medicine if you have uric acid kidney stones, a gout attack that has already started, or a blood cell disorder.
Call your doctor if you have worsening gout symptoms.
Why is this medication prescribed?
Procid is used to treat chronic gout and gouty arthritis. It is used to prevent attacks related to gout, not treat them once they occur. It acts on the kidneys to help the body eliminate uric acid. Procid is also used to make certain antibiotics more effective by preventing the body from passing them in the urine.
This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
Pharmacologic class: Sulfonamide-derived uricosuric
Therapeutic class: Antigout drug, tubular blocking agent
Pregnancy risk category B
Exacerbation of gout following therapy with Procid may occur; in such cases colchicine or other appropriate therapy is advisable.
Procid increases plasma concentrations of methotrexate in both animals and humans. In animal studies, increased methotrexate toxicity has been reported. If Procid is given with methotrexate, the dosage of methotrexate should be reduced and serum levels may need to be monitored.
In patients on Procid the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of Procid. The biphasic action of salicylates in the renal tubules accounts for the so-called “paradoxical effect” of uricosuric agents. In patients on Procid who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred.
Rarely, severe allergic reactions and anaphylaxis have been reported with the use of Procid. Most of these have been reported to occur within several hours after re-administration following prior usage of the drug.
The appearance of hypersensitivity reactions requires cessation of therapy with Procid.
PRINCIPAL DISPLAY PANEL
NDC 10135-541-10 Procid Tablets, USP 500 mg 1000 Tablets Rx Only
Where can I get more information (Benemid)?
Your pharmacist can provide more information about Procid.